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习保民



姓名:习保民
职称:副教授,硕士生导师
联系邮箱:xibaomin@sohu.com
联系电话:020-61648549

学习经历:
1989.9-1993.6 赣南师范学院 ,化学,学士
1995.9-1998.6 南开大学,物理化学,硕士
2000.9-2005.6 中国药科大学,药物化学,博士

工作经历:
1998.7-2001.8 中国药科大学,助教
2001.9-2006.12 中国药科大学,讲师
2007.1-2007.6 中国药科大学,副教授
2007.7- 南方医科大学,副教授

研究方向:
1. 抗糖尿病药物的设计,合成及活性测试;
2. 心血管药物的设计,合成及活性测试;

代表性论文:
(1) WANG Wenling, JIANG Huixian,PANG Jianxin, JIANG Zhihong, Bao-min XI * Design, synthesis and characterization of cyanopyrrolidine-bearing compounds as DPP-4 Inhibitors. J. South. Med. Univ. 2012, 32 (2), 177 – 180.
(2) Shou-Hua ZHANG, Chun-Ye WANG, Zhen-Zhou JIANG, Pei-Zhou NI, Jin-Pei ZHOU, Bao-Min XI*, Wen-Hua CHEN, Synthesis and Blocking Activities of Isoindolinone- and Isobenzofuranone- Containing Phenoxylalkylamines as Potent α1-Adrenoceptor Antagonists Chem. Pharm. Bull. 2011, 59(1), 96 - 99.
(3) Bao-Min Xi, Zhen-Zhou Jiang, Jian-Wei Zou, Pei-Zhou Ni, Wen-Hua Chen. Drug metabolism- based design, synthesis, and bioactivities of (2,6-dimethylphenoxy)-2-(3,4- dimethoxy phenylethyl- amino)propane hydrochloride (DDPH) analogs as α1-adrenoceptors antagonists. Bioorg. Med. Chem. 2011, 19: 783-788.
(4) WU Dian-qing, J IANG Zhen-zhou, ZHANG Hui-bin, Bao-min X I*, WANG Tao , NI Pe i-zhou Synthesis and biolog ica l activ ity of carbamoyl substituted phenoxylalkylam ine derivatives. Chin. J. Med. Chem. 2010, 20, 181-186.
(5) Hai-Quan Wang, Wang-Zhong Chen, Wen-Hua Chen and Bao-Min Xi* 2-(5-Bromopentyl)-4- chloro-5-[2-(4-methoxyphenyl)ethylamino]pyridazin-3(2H)-one Acta Cryst. (2010). E66, o2215
(6) Bao-Min Xi*, Pei-Zhou Ni, Zhen-Zhou Jiang, Dian-Qing Wu, Shou-Hua Zhang Hui-Bin Zhang, Tao Wang and Wen-Hua Chen Synthesis and Blocking Activities of a New Class of α1-Adrenoceptor Antagonists Chem. Biol. Drug. Des. 2010; 76: 505–510.
(7) Bao-Min Xi, Zhen-Zhou Jiang, Tao Wang, Pei-Zhou Ni. Synthesis and biological activity of cyclosulfonamide substituted phenylethylamine and phenoxyl- alkylamine derivatives. Chinese Journal of Organic Chemistry. 2009, 29 (7), 1161-1164.
(8) WANG Rong-rong, JANG Zhen-zhou XI Bao-min, WANG Tao, LIU Jing, LIANG Zhong-liang , ZHANG Lu-yong Study on phenylethylamines new compounds against benign prostatic hyperplasia. Chin. J. of Clin.l Pharm. and Therap. 2009, 14(7): 726-731。
(9) Dian-Qing Wu, Hui-Bin Zhang, Bao-Min Xi*. 4-[2-(3,4-Dimethoxyphenethylamino) propoxy]- 2-methoxybenzamide. Acta Crystallographica. 2008, E64, o1155.
(10) Bao-min XI,JIANG Zhen-zhou,WANG Tao,NI Pei-zhou. Synthesis and biological activity of 2,4-dimethoxyphenylethylamines as α1-AR antagonist Chin. J. Med. Chem.2008, (18) 6, 401-405.
(11) Bao-Min Xi, Zhen-Zhou Jiang, Tao Wang, Pei-Zhou Ni. Studies on the synthesis and biological activity of pyridazinone derivatives as α1-adrenoceptor antagonists. Chin. J. Org. Chem. 2006, 26 (11), 1576-1583.
(12) XI Bao-min, Li Hua, ZHANG Bin, NI Pei-zhou, Xia Lin, JIANG Zhen-zhou. Study on the synthesis, biological activity and QSAR of halophenoxylalkylamines as α1-AR antagonist Chin. J. Med. Chem.2005, 15(1). 5 - 11.
(13) XI Boa-min, ZHAO Wen-Na, ZOU Jian-Wei, NI Pei-zhou. Comparative Molecular Field Analysis (CoMFA) of α1-Adrenocepter Antagonist DDPH and Its Analogues. Chin. J. Struct. Chem.2004, 23(8): 962-968.
(14) SONG Hao, CAI Zun-sheng, ZHAO Xue-zhuang, LI Yong-jun, XI Bao-min LI Yan-ni. A new method of controlling chemical chaos  Nonlinear artificial neural network (ANN)-occasional perturbation feedback control in the whole chaotic region. Science in China (Series B). 1999, 42(6): 624-630.
(15) LI Yong-jun, CAI Zun-sheng, LI Yan-ni, SONG Da-hai, SONG Hao,, XI Bao-min, ZHAO Xue-zhuang. Reconstructing the state space of chaotic BZ Reaction system using Power Spectrum Method. Chinese Science Bulletin. 1998, 43 (13): 1404-1409.

专利
(1) Bao-Min Xi, Pei-Zhou Ni, Zhen-Zhou Jiang, Tao Wang. A synthetic method of α1-adrenoceptor antagonists and their medical applications. CN200910024457.5.
(2) Bao-Min Xi, Hai-Quan Wang, Zhen-Zhou Jiang, Wang-zhong Chen, Wen-hua Chen, Jian-xin Pang. Synthetic method of Phenylpiperazinepyridazinone and their medical applications. CN 201210392666.7.
(3) Bao-Min Xi, Chun-Ye Wang, Zhen-Zhou Jiang, Wang-zhong Chen, Jian-xin Pang, Wen-hua Chen, Bao-ping Xie, Ying Cao. Synthetic method of 2,6-disubstituted pyridazones and their applications. CN201310257896.7.
(4) Bao-Min Xi, Chun-Ye Wang, Zhen-Zhou Jiang, Wang-zhong Chen, Jian-xin Pang, Wen-hua Chen, Bao-ping Xie, Ying Cao. A synthetic method of 6-(4-arylpiperazin-1-yl) pyridazine-3(2H)-one and their medical applications.CN201310257897.1.
(5) Shu-Wen Liu, Rui-Tao Zhang, Bao-Min Xi, Bo-Jiang Zheng. 3 - fluoro-5 - (trifluoromethyl)-N-(2 - (1-piperidinyl) ethyl) benzamide hydrochloride in preparing anti-H5N1 avian influenza virus drugs and animal feed applications CN200910042286.9.




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