神经精神药理学科在Neuropharmacology上发表Invited Review

近日，神经精神药理学科徐江平教授课题组在Neuropharmacology上发表了题为“Forkhead Box O Transcription Factors as Possible Mediators in the Development of Major Depression”的邀请综述（invited review）。
该论文为一篇前瞻性综述（prospective review），论文首先阐述了Forkhead转录因子FoxO的信号通路及在脑内不同脑区的分布及表达情况，随后重点从FoxO在抑郁样行为中的活性变化、抗抑郁药对FoxO磷酸化及核转位的调节、单胺类神经递质及下丘脑-垂体-肾上腺轴对FoxO的调控、FoxO在与抑郁症相关的神经元形态及神经萎缩中的作用、FoxO在神经发生及突触再生中的作用等几方面前瞻性提出FoxO可能为重度抑郁症发生发展过程中的重要调节因子。文章并指出了目前FoxO与抑郁症关系的研究存在的不足以及以FoxO为靶点进行抗抑郁药物研究需要注意的问题，为下一步的研究提出了新的方向及思路。
论文受到国家自然科学基金、广东省自然科学基金、中国博士后科学基金等项目资助，汪海涛博士为该论文第一作者，徐江平教授为共同通讯作者，Neuropharmacology为医学大类2区杂志，神经科学小类2区杂志，药学小类2区杂志，IF=5.106.

Wang H, Quirion R, Little PJ, Cheng Y, Feng ZP, Sun HS, Xu J*, Zheng W*. Forkhead Box O Transcription Factors as Possible Mediators in the Development of Major Depression. Neuropharmacology, 2015, 99, 527-537.

Abstract
Forkhead box O (FoxO) transcription factors play important roles in cellular physiology and biology. Recent findings indicate that FoxOs are also involved in the development of major depressive disorder. Alterations in the upstream molecules of FoxOs, such as brain derived neurotrophic factor or protein kinase B, have been linked to depression. Antidepressants, such as imipramine and venlafaxine, modify the FoxOs phosphorylation. Furthermore, FoxOs could be regulated by serotonin and norepinephrine receptor signaling as well as the hypothalamic-pituitary-adrenal axis, all of which are involved in the pathogenesis of depression. FoxOs also regulate neuronal morphology, synaptogenesis and adult hippocampal neurogenesis, which are viewed as candidate mechanisms for the etiology of depression. In this review, we emphasize the possible roles of FoxOs during the development of depression and make some strategic recommendations for future research. We propose that FoxOs and its signaling pathways may constitute potential therapeutic targets in the treatment of depression.