Education

1998-2001，Sun Yat-sen Medical University，Ph.D.

1994-1997，Sun Yat-sen Medical University，M.S.

1989 -1994，Shandong Medical University，B.S.

Experience

2007 - present，Professor, Department of Neurobiology, Southern Medical University

2003-2007，Postdoctoral Research Fellow, Emory University, USA

2001-2003，Postdoctoral Research Fellow, Brown University, USA

Research Interests

Neurodegenerative diseases are disorders due to the loss of structure and function of neurons. Although the molecular mechanism of neuronal loss has been extensively investigated, there are currently no effective treatments to prevent or reverse neurologic deficits in neurodegenerative diseases. Our group has been studying the molecular mechanism of neuronal cell death, focusing on the role of transcription factors, such as PPARgamma.

Neurological diseases, such as Alzheimer’s disease and depression, have been established comorbidities in diabetic patients. Neurological and metabolic disorders may share common risk factors. We have been studying the mechanism of neurological disorders driven by metabolic dysfunction.

Publication

1. Su X, Gu X, Zhang Z, Li W, Wang X*. Retinoic acid receptor gamma is targeted by microRNA-124 and inhibits neurite outgrowth. Neuropharmacology, 2020, 163:107657.

2. Xu L#, Xu S#, Lin L, Gu X, Fu C, Fang Y, Li X, Wang X*. High-fat diet mediates anxiolytic-like behaviors in a time-dependent manner through the regulation of SIRT1 in the brain. Neuroscience，2018, 372:237-245.

3. Gu X, Fu C, Lin L, Liu S, Su X, Li A, Wu Q, Jia C, Zhang P, Chen L, Zhu X, Wang X*. miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway. Journal of Cellular Physiology. 2018，233(1):673-687.

4. Gu X#, Li A#, Liu S, Lin L, Xu S, Zhang P, Li S, Li X, Tian B, Zhu X, Wang X* . MicroRNA124 Regulated Neurite Elongation by Targeting OSBP. Molecular Neurobiology，2016，53(9):6388-6396.

5. Qin X#, Wu Q#, Lin L, Sun A, Liu S, Li X, Cao X, Gao T, Luo P, Zhu X, Wang X*. Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism. Molecular Neurobiology，2015, 52(1):187-195.

6. Wang X#，She H#，Mao Z*. Phosphorylation of Neuronal Survival Factor MEF2D by Glycogen Synthase Kinase 3 beta in Neuronal Apoptosis. Journal of Biological Chemistry，2009，284（47）：32619-32626.

7. Tang X#，Wang X#，Gong X，Tong M，Park D，Mao Z*. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. Journal of Neuroscience，2005，25（19）：4823-4834.

8. Wang X#，Tang X#，Li M，Marshall J，Mao Z*. Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. Journal of Biological Chemistry，2005，280（17）：16705-16713.

9. Xuemin Wang, Xiaoli Tang, Xiaoming Gong, Efsevia Albanis, Scott L Friedman, Zixu Mao. Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. Gastroenterology, 2004 Oct;127(4):1174-88.