Education

2008-2013, Model Animal Research Center of Nanjing University, Ph.D

2004-2008, Nanjing University, Bachelor

Experience

2024-present，Southern Medical University, Professor

2021-2024，Crown Bioscience, Study director

2015-2021，University of California, San Francisco, Postdoc

Research Introduction

Sleep is an area of increasing attention for its close relevance to human health, including physical, emotional health as well as cognitive performance. Nowadays, more and more people are suffering from sleep disorders because of the fast-paced life. The focus of our lab is to investigate the mechanism of sleep regulation and aims to develop drugs to treat sleep disorders.

Selected publications

1. Lijuan Xing, Xianlin Zou, Chen Ying, John Webb, Guangsen Shi, Louis J. Ptáček and Ying-Hui Fu. Diverse roles of pontine NPS neurons in sleep regulation. PNAS, 2024, 121 (9) e2320276121.

2. Lijuan Xing^*, Guangsen Shi^*, Yulia Mostovoy, Nicholas W. Gentry, Zenghua Fan, Thomas B. McMahon, Pui-Yan Kwok, Christopher R. Jones, Louis J. Ptáček and Ying-Hui Fu. Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation. Science Translational Medicine, 2019, 11(514): eaax2014.

3. Lijuan Xing, Yang An, Guangsen Shi, Jie Yan, Pancheng Xie, Zhipeng Qu, Zhihui Zhang, Zhiwei Liu, Dejing Pan, Ying Xu. Correlated evolution between CK1δ Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock.Journal of Biological Chemistry, 2017, 292(1), 161-171.

4. Guangsen Shi^*, Lijuan Xing^*, Zhiwei Liu, Zhipeng Qu, Xi Wu, Zhen Dong, Xiaohan Wang, Xiang Gao, Moli Huang, Jie Yan, Lin Yang, Yi Liu, Louis J. Ptáček, Ying Xu. Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. PNAS, 2013, 110(12), 4750-4755.

5. Xiwen Gu^*, Lijuan Xing^*, Guangsen Shi, Zhiwei Liu, Xiaohan Wang, Zhipeng Qu, Xi Wu, Zhen Dong, Xiang Gao, Geng Liu, Ling Yang and Ying Xu. The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell death and differentiation, 2012, 19(3), 397-405.

(*co-first authors)