姓名：谢卫兵
电子邮箱：xwb@smu.edu.cn
工作单位：南方医科大学法医学院
职称：副研究员
导师资格：博士生导师
学术任职：中国法医学会会员，中国毒理学会会员，广东省精准医学应用学会法医学分会秘书长
个人简介：
谢卫兵，副研究员，博士生导师，广东省精准医学应用学会法医学分会秘书长。长期从事司法鉴定的教学、科研和鉴定工作，现主要聚焦于新型毒品（甲基苯丙胺等）毒性机制及心血管疾病发生的分子机制研究。主持国家自然科学基金面上项目2项，省市科技项目3项。以第一作者或通讯作（含并列）在Circ Res, J Biol Chem, Cell Death Dis, FASEB J, BBA-Molecular Basis of Disease, Mol Neurobiol, Toxicol Sci，Toxicol Lett，Toxicol Appl Pharmacol，Front Mol Neurosci等国外著名期刊上发表SCI论文20余篇。
科研项目：
1. 国家自然科学基金面上项目：Nupr1介导血管稳态失衡在甲基苯丙胺相关的肺动脉高压发生中的作用及机制（82170438）,2022.01-2025.12, 55万, 主持，在研
2.广东省基础与应用基础研究基金项目：Nupr1在肾纤维化发生发展中的作用及分子机制（2019A1515010271）,2019.10-2022.9, 10万，主持，在研
3.国家卫生健康委员会毒品依赖和戒治重点实验室开放课题：甲基苯丙胺通过Nupr1调控STIM1/Orai钙离子通道开放诱导肺动脉高压发生（2020DAMOP-010），2020.8-2022.7,15万，主持，结题
4.广州科技计划项目：甲基苯丙胺（METH）致动脉夹层发生机制及防治（201707010302），2017.5-2020.4， 20万，主持，结题
5.国家自然科学基金面上项目：NDRG1在血管损伤后新生内膜形成中的作用及其分子机制（81370227），2014.1-2017.12，65万，主持，结题
代表性论文/著作
1. Luo BY#, Zhou J#, Guo D#, Yang Q, Tian Q, Cai DP, Zhou RM, Xu ZZ, Wang HJ*, Chen SY*, Xie WB*. Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166447. doi: 10.1016/j.bbadis.2022.166447.
2. Ruimei Zhou#, Jiashun Liao#, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lü, Shi-You Chen*, Wei-Bing Xie*.Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial-mesenchymal transition FASEB J 2021 Mar; 35(3): e21381. doi: 10.1096/fj.202000926RR
3. Sun X, Wang Y, Xia B, Li Z, Dai J, Qiu P, Ma A, Lin Z, Huang J, Wang J, Xie WB*, Wang J*. Methamphetamine produces cardiac damage and apoptosis by decreasing melusin Toxicol Appl Pharmacol. 2019 Sep 1;378:114543. doi: 10.1016/j.taap.2019.03.015. Epub 2019 Mar 20. PMID: 30904475
4. Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H*, Xie WB*. CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicol Lett. 2018 Aug;292:97-107. doi: 10.1016/j.toxlet.2018.04.027. Epub 2018 Apr 26. PMID: 29705343
5. Xu X, Huang E, Luo B, Cai D, Zhao X, Luo Q, Jin Y, Chen L, Wang Q, Liu C, Lin Z, Xie WB*, Wang H*. Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells by activating the C/EBPβ-related signaling pathway. FASEB J. 2018 Jun 25:fj201701460RRR. doi: 10.1096/fj.201701460RRR. Online ahead of print. PMID: 29939784
6. Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB*, Wang H*. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Mol Neurobiol. 2017 Apr;54(3):1642-1660. doi: 10.1007/s12035-015-9637-9. Epub 2016 Feb 12. PMID: 26873849
7. Du SH, Qiao DF, Chen CX, Chen S, Liu C, Lin Z, Wang H*, Xie WB*. Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes. Front Mol Neurosci. 2017 Dec 12;10:409. doi: 10.3389/fnmol.2017.00409. eCollection 2017. PMID: 29311802
8. Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H*, Xie WB*. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017. PMID: 28694771
9. D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie*, H Wang*. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine Cell Death Dis . 2016 Mar 31;7(3):e2161. doi: 10.1038/cddis.2016.67.
10. Hu ZY#, Xie WB#, Yang F, Xiao LW, Wang XY, Chen SY, Li ZG. NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling. Biochim Biophys Acta. 2015 Sep;1852(9):1876-86. doi: 10.1016/j.bbadis.2015.06.009. Epub 2015 Jun 10. PMID: 26071641
11. Huang W#, Xie WB#, Qiao D#, Qiu P#, Huang E, Li B, Chen C, Liu C, Wang Q, Lin Z, Wang H*. Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Sci. 2015 May;145(1):68-79. doi: 10.1093/toxsci/kfv014. Epub 2015 Jan 27. PMID: 25631491
12. Wei-Bing Xie#, Zuguo Li#, Ning Shi, Xia Guo, Junming Tang, Wenjun Ju, Jun Han, Tengfei Liu, Erwin P Bottinger, Yang Chai, Pedro A Jose, Shi-You Chen Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells Circ Res 2013 Sep 27;113(8):e76-86. doi: 10.1161/CIRCRESAHA.113.301921. Epub 2013 Jul 1.
13. Li Z#, Xie WB#, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY. Response gene to complement 32 is essential for fibroblast activation in renal fibrosis. J Biol Chem. 2011 Dec 2;286(48):41323-41330. doi: 10.1074/jbc.M111.259184. Epub 2011 Oct 11. PMID: 21990365
14. Xie WB, Li Z, Miano JM, Long X, Chen SY. Smad3-mediated myocardin silencing: a novel mechanism governing the initiation of smooth muscle differentiation. J Biol Chem. 2011 Apr 29;286(17):15050-7. doi: 10.1074/jbc.M110.202747. Epub 2011 Mar 14. PMID: 21402709
15. Wang JN, Shi N, Xie WB, Guo X, Chen SY. Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):e19-26. doi: 10.1161/ATVBAHA.111.230706. Epub 2011 Jun 2. PMID: 21636805
