个人简介
一、教学
讲授《法医毒物分析》
二、研究领域
法医毒理学（1）神经毒理机制研究；（2）脑代谢疾病病理机制研究
三、学术兼职
中国法医学会法医毒物专业委员会委员；第一届海峡两岸医药卫生交流协会法医学分会委员；第二届海峡两岸医药卫生交流协会法医学分会委员；《Frontiers in Cellular Neuroscience》副主编；《Pharmaceuticals》专题主编；《Frontiers in Psychiatry》专题主编；Springer Nature系列丛书《Advances in Neurobiology》编委；《ACTA PHYSIOLOGICA》编委；《Military Medical Research》青年委员；《Neuroscience Bulletin》青年委员；《Brain-X》青年委员。
四、个人成果
1.学术论文
1. Li B*, Sun Q, Ding F, Xu Q, Kang N, Xue Y, Ladron-de-Guevara A, Hirase H, Weikop P, Gong S, Smith N, Nedergaard M*. Anti-seizure effects of norepinephrine-induced free fatty acid release. Cell Metabolism. 2025;37(1):223-238.
2. Li X, Wang S, Zhang D, Feng Y, Liu Y, Yu W, Cui L, Harkany T, Verkhratsky A*, Xia M*, Li B*. The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs. Proc Natl Acad Sci U S A. 2024;121(45):e2400024121.
3. Cui L, Li S, Wang S, Wu X, Liu Y, Yu W, Wang Y, Tang Y, Xia M*, Li B*. Major depressive disorder: hypothesis, mechanism, prevention and treatment. Signal Transduct Target Ther. 2024;9(1):30.（封面及高被引论文）
4. Li X, Chen B, Zhang D, Wang S, Feng Y, Wu X, Cui L, Ji M, Gong W, Verkhratsky A*, Xia M*, Li B*. A novel murine model of mania. Molecular Psychiatry. 2023; 28(7):3044-3054.
5. Li B, Tian Y*, Wang P*. Applications and grants of the National Natural Science Foundation of China's General Program and Young Scientists Fund in immunology research: a 10-year review (2013-2022). Sci China Life Sci. 2024; 67(6):1321-1324.
6. Zhang M, Gong W, Zhang D, Ji M, Chen B, Chen B, Li X, Zhou Y, Dong C, Wen G, Zhan X, Wu X, Cui L, Feng Y, Wang S, Yuan H, Xu E, Xia M, Verkhratsky A*, Li B*. Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment. Cell Death & Disease. 2022. 25;13(4):406.
7. Li B, Yu W, Verkhratsky A*. Trace metals and astrocytes physiology and pathophysiology. Cell Calcium. 2024;118:102843.
8. Gong W, Li X, Feng Y, Ji M, Zhang D, Chen B, Wang S, Wu X, Cui L, Li B*, Xia M*. Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice. J Psychiatr Res. 2023;161:188-198.
9. Zhang D, Li X, Li B*. Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders. Frontiers in Aging Neuroscience. 2022; 14:873697.
10. Li B, Zhang D, Verkhratsky A*. Astrocytes in Post-traumatic Stress Disorder. Neuroscience Bulletin. 2022;29:1–13.
11. Chen B, Zhang M, Ji M, Zhang D, Chen B, Gong W, Li X, Zhou Y, Dong C, Wen G, Zhan X, Wu X, Yuan H, Xu E, Xia M, Verkhratsky A*, Li B*. The neuroprotective mechanism of lithium after ischaemic stroke. Communications Biology. 2022;3;5(1):105.
12. Ji M, Gong W, Wang S, Zhang D, Chen B, Li X, Wu X, Cui L, Feng Y, Verkhratsky A*, Li B*. Leptin Attenuates Fear Memory by Inhibiting Astrocytic NLRP3 Inflammasome in Post-traumatic Stress Disorder Model. Neurochemical Research. 2023;48(4):1180-1190.
13. Guan W, Xia M, Ji M, Chen B, Li S, Zhang M, Liang S, Chen B, Gong W, Dong C, Wen G, Zhan X, Zhang D, Li X, Zhou Y, Guan D*, Verkhratsky A*, Li B*. Iron induces two distinct Ca2+ signalling cascades in astrocytes. Communications Biology. 2021;5;4(1):525.
14. Chen B, Zhang M, Ji M, Gong W, Chen B, Zorec R, Stenovec M, Verkhratsky A*, Li B*. The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta-analysis of the Literature. Neurochemical Research. 2021; 46(10):2731-2745.
15. Li B, Xia M, Zorec R, Parpura V, Verkhratsky A. Astrocytes in heavy metal neurotoxicity and neurodegeneration. Brain Research. 2021;1752:147234.
16. Xia M, Liang S, Li S, Ji M, Chen B, Zhang M, Dong C, Chen B, Gong W, Wen G, Zhan X, Zhang D, Li X, Zhou Y, Guan D, Verkhratsky A*, Li B*. Iatrogenic Iron Promotes Neurodegeneration and Activates Self-Protection of Neural Cells against Exogenous Iron Attacks. Function (Oxford, England). 2021; 12; 2(2).
17. Li Z, Lu Y, Liang S, Li S, Chen B, Zhang M, Xia M, Guan D*, Verkhratsky A*, Li B*. Fluoxetine improves behavioural deficits induced by chronic alcohol treatment by alleviating RNA editing of 5-HT2C receptors. Neurochemistry International. 2020;134:104689.
18. Liang S, Lu Y, Li Z, Li S, Chen B, Zhang M, Chen B, Ji M, Gong W, Xia M, Verkhratsky A*, Wu X*, Li B*. Iron Aggravates the Depressive Phenotype of Stressed Mice by Compromising the Glymphatic System. Neuroscience Bulletin. 2020; 36(12):1542-1546.
19. Xia M, Li Z, Li S, Liang S, Li X, Chen B, Zhang M, Dong C, Verkhratsky A, Guan D, Li B*. Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT 2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice. Neuroscience Bulletin. 2020; 36(11):1259-1270.
20. Li Y, Wen G, Ding R, Ren X, Jing C, Liu L, Yao J, Zhang G, Lu Y*, Li B*, Wu X*. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of Molecular Neuroscience. 2020; 70(12):2068-2076.
21. Verkhratsky A, Nedergaard M, Steardo L, Li B*. Editorial: Sleep and Mood Disorders. Frontiers in Psychiatry. 2020; 16;10:981.
22. Zhao X#, Li Z#, Liang S, Li S, Ren J, Li B*, Zhu Y*, Xia M*. Different epidermal growth factor receptor signaling pathways in neurons and astrocytes activated by extracellular matrix after spinal cord injury. Neurochemistry International. 2019; 129:104500.
23. Yue T, Li B*, Gu L, Huang J, Verkhratsky A, Peng L*. Ammonium induced dysfunction of 5-HT2B receptor in astrocytes. Neurochemistry International. 2019; 129:104479.
24. Li X, Liang S, Li Z, Li S, Xia M, Verkhratsky A, Li B*. Leptin increases expression of 5-HT2B receptors in astrocytes thus enhancing action of fluoxetine on the depressive behavior induced by sleep deprivation. Frontiers in Psychiatry. 2019; 7;9:734.
25. Li B, Ren J, Yang L, Li X, Sun G, Xia M*. Lithium Inhibits GSK3β Activity via Two Different Signaling Pathways in Neurons After Spinal Cord Injury. Neurochemical Research. 2018; 43(4):848-856.
26. Jia S, Li B*, Huang J, Verkhratsky A, Peng L*. Regulation of Glycogen Content in Astrocytes via Cav-1/PTEN/AKT/GSK-3β Pathway by Three Anti-bipolar Drugs. Neurochemical Research. 2018; 43(8):1692-1701.
27. Xia M, Li X, Yang L, Ren J, Sun G, Qi S, Verkhratsky A, Li B*. The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation. Journal of Neurochemistry. 2018;146:63-75
28. Li B，Jia S, Yue T, Yang L, Huang C, Verkhratsky A, Peng L*. (2017) Biphasic regulation of caveolin-1 gene expression by fluoxetine in astrocytes: opposite effects of PI3K/AKT and MAPK/ERK signalling pathways on c-fos. Frontiers in Cellular Neuroscience. 2017; 31;11:335.
29. Xia M, Yang L, Sun G, Qi S, Li B*. Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system. Psychopharmacology. 2017; 234(3):365-379.
30. Achariyar TM#, Li B#, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R*. Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Mol Neurodegener. 2016；11:74. (高被引论文)
31. Peng W#, Achariyar TM#, Li B#, Liao Y#, Mestre H, Hitomi E, Regan S, Kasper T, Peng S, Ding F, Benveniste H, Nedergaard M, Deane R*. Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease. Neurobiology of Disease. 2016; 93:215-25.
32. Li B, Qi S, Sun G, Yang L, Han J, Zhu Y, Xia M*. Leptin suppresses adenosine triphosphate-induced impairment of spinal cord astrocytes. Journal of Neuroscience Research. 2016; 94:924-35.
33. Lundgaard I#, Li B#, Xie L#, Kang H, Sanggaard S, Haswell JD, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M*. Direct neuronal glucose uptake Heralds activity-dependent increases in cerebral metabolism. Nature Communications. 2015; 6:6807.(高被引论文)
34. Dong L#, Li B#, Verkhratsky A, Peng L*. Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine. Psychopharmacology (Berl). 2015; 232:2827-35.
35. Li B, Hertz L, Peng L*. Cell-specific mRNA alterations in Na+, K+-ATPase alpha and beta isoforms and FXYD in mice treated chronically with carbamazepine, an anti-bipolar drug. Neurochemical Research. 2013; 38:834-41.
36. Li B, Gu L, Hertz L, Peng L*. Expression of nucleoside transporter in freshly isolated neurons and astrocytes from mouse brain. Neurochemical Research. 2013; 38:2351-8.
37. Li B*, Dong L, Wang B, Cai L, Jiang N, Peng L. Cell type-specific gene expression and editing responses to chronic fluoxetine treatment in the in vivo mouse brain and their relevance for stress-induced anhedonia. Neurochemical Research. 2012; 37:2480-95.
38. Li B, Hertz L, Peng L*. Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes. Neurochemistry International. 2012; 61:1325-32.
39. Li B, Zhang S, Zhang H, Hertz L, Peng L*. Fluoxetine affects GluK2 editing, glutamate-evoked Ca(2+) influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes. Journal of Psychiatry & Neuroscience. 2011; 36:322-38.
40. Li B, Dong L, Fu H, Wang B, Hertz L, Peng L*. (2011) Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity. Cell Calcium. 2011; 50:42-53.
41. Du T#, Li B#, Li H, Li M, Hertz L, Peng L*. Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent. Journal of Neurochemistry. 2010; 115:1007-23.
42. Li B, Zhang S, Li M, Hertz L, Peng L*. Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors. Neurochemistry International. 2010; 57:432-9.
43. Li B, Zhang S, Li M, Zhang H, Hertz L, Peng L*. Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons. Neuropharmacology. 2009; 57:375-85.
44. Li B, Zhang S, Li M, Hertz L, Peng L*. Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation. Psychopharmacology. 2009; 207:1-12.
45. Li B, Du T, Li H, Gu L, Zhang H, Huang J, Hertz L, Peng L*. Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. British Journal of Pharmacology. 2008; 154:191-203.
46. Li B, Zhang S, Zhang H, Nu W, Cai L, Hertz L, Peng L*. Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation. Psychopharmacology. 2008; 201, 443-58.
47. Li B, Gu L, Zhang H, Huang J, Chen Y, Hertz L, Peng L*. Up-regulation of cPLA(2) gene expression in astrocytes by all three conventional anti-bipolar drugs is drug-specific and enzyme-specific. Psychopharmacology. 2007; 194:333-45.
2.科研项目（纵向+横向，包含人才项目）
国家自然科学基金面上项目：缺血性脑卒中后锂盐通过抑制NLRP3验炎症小体活化促进神经功能恢复的机制研究（编号：81871852），2019.01-2022.12，57万，主持人，结题。
国家自然科学基金青年基金项目：氟西汀调节星形胶质细胞Ca2+库作用机制的研究（编号：31000479），2011.01-2013.12，20万，主持人，结题。
辽宁省“兴辽英才计划”青年拔尖人才项目：脑胶质淋巴系统调节神经细胞微环境的机制研究（编号XLYC1807137），2019.01-2021.12，50万，主持人，结题。
辽宁省教育厅基本科研项目重点项目：创伤后应激障碍的诊断指标识别与发病机制研究（编号：LJ212410159042），2024.7.20-2025.7.19，30万，主持人，结题。
辽宁省科技计划联合计划（基金）项目：阿尔兹海默病早期临床诊断指标识别和治疗药物研究（编号：辽科发规[2023]67号），2023.12-2025.12，8万，主持人，结题。
沈阳市中青年科技创新人才支持计划项目：创伤后应激障碍发病机制的法医学研究（编号：RC210251），2021.01-2024.12，10万，主持人，结题。
2023年度辽宁省研究生教育教学改革研究项目：研究生实验技能和创新能力培养的实践与探索（编号：辽教通〔2023〕385号），2023.09-2025.08，0.5万，主持人，结题。
2019年度辽宁省“百千万人才工程”资助项目：衰老相关ApoE4在阿尔茨海默病发生早期的识别研究（编号：辽人社函[2020]78号），2020.07-2022.06，5万，主持人，结题。
教育部“春晖计划”合作科研项目：锂盐调控β-catenin对缺血性脑卒中的神经保护作用及其机制研究（编号：教外司人文〔2020〕703号），2021.01-2023.12，3万，主持人，结题。
教育部留学回国人员科研启动基金：去甲肾上腺素对神经元和星形胶质细胞体积及钠钾泵活性相反作用的机制研究（编号：20151098），2016.01-2018.12，3万，主持人，结题。
3.教学项目
辽宁省研究生教育教学改革研究项目，研究性实验技能和创新能力培养的实践研究，省级立项，主持人。
4.成果奖励（科研、教学）
沈阳市高层次人才拔尖人才（2020）
辽宁省“百千万人才工程”千人层次（2019）
辽宁省“兴辽英才计划”青年拔尖人才（2018）
辽宁省科学技术进步三等奖（第一完成人）（2017）
辽宁省医学科技二等奖（第一完成人）（2016）
第七届“全国大学生基础医学创新研究暨实验设计论坛”总决赛（国家级科研竞赛）优秀指导教师
第七届“全国大学生基础医学创新研究暨实验设计论坛”总决赛优秀成果奖（国家级）金奖
第七届“全国大学生基础医学创新研究暨实验设计论坛”总决赛优秀成果奖（国家级）银奖
第九届“全国大学生基础医学创新研究暨实验设计论坛”总决赛（国家级科研竞赛）优秀指导教师
第九届“全国大学生基础医学创新研究暨实验设计论坛”本科院校总决赛法医学赛道优秀成果奖（国家级）金奖
第九届“全国大学生基础医学创新研究暨实验设计论坛”本科院校法医学赛道复赛优秀成果奖（省级）一等奖
第九届“全国大学生基础医学创新研究暨实验设计论坛”校赛一等奖
中国医科大学2020年大学生基础医学创新论坛暨实验设计论坛一等奖
2018-2020年度中国医科大学“三八红旗手标兵
中国医科大学2024年及2025年优秀科技工作者
中国医科大学法医学院“双一流”建设贡献奖（2024）
5.教材著作
主编，论著《Astrocytes in Psychiatric Disorders》，Springer-Nature出版社，2021
主编，论著《Sleep and Mood Disorders》，Frontiers Media SA出版社，2020
主编，论著《神经胶质细胞》，人民卫生出版社，2022
编委，《法医毒物司法鉴定实务》，科学出版社，2025
6.授权专利和计算机软件著作权
中国发明专利授权：《一种小鼠躁狂症模型多功能创建箱》（专利号：ZL 2021 2 2205974.1，证书号第15608826号，授权公告号：CN 215606505 U，授权公告日：2022年01月25日），排名第1。
中国发明专利授权：《一种带有常见毒品快速检测功能的尿液样品采集瓶》（专利号：ZL 2023 2 0392846.9，证书号第19749282号，授权公告号：CN 219770436 U，授权公告日：2023年09月29日），排名第1。
