一、教学

讲授《法医物证学学》

二、研究领域

法医病理学 （1）甲基苯丙胺（METH）的心血管系统损伤研究；（2）心血管疾病发病机制研究

三、学术兼职

广东省精准医学应用学会法医学分会秘书长

四、个人成果

1. 学术论文

Zhou J^#, Xu Z^#, Peng DB^#, Li X,Chang S, Duan K, Jiang Y, Gu C,Peng X, Xie WB*. Macrophage-Derived LCN2 Promotes Methamphetamine-Induced Pulmonary Hypertension. Hypertension. 2025 Aug;82(8):1355-1367.

Tian Q^#, Zhou J^#, Xu Z, Wang B, Liao J, Duan K, Li X, Huang E, Xie WB*. STIM1 mediates methamphetamine induced neuronal autophagy and apoptosis. Neurotoxicology. 2024 Jul; 103:134-145.

Zhou J^#, Guo D^#, Xu ZZ, Liao JS, Li XT, Duan K, Chen SY, Xie WB*. Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension. Cell Biol Toxicol. 2024 Feb 13;40(1):13.

Xu ZZ^#, Zhou J^#, Duan K, Li XT, Chang S, Huang W, Lu Q, Tao J, Xie WB*. Blocking Sigmar1 exacerbates methamphetamine-induced hypertension. Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167284.

Luo BY^#, Zhou J^#, Guo D^#, Yang Q, Tian Q, Cai DP, Zhou RM, Xu ZZ, Wang HJ*, Chen SY*, Xie WB*.Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166447.

Ruimei Zhou^#, Jiashun Liao^#, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lü, Shi-You Chen*, Wei-Bing Xie*. Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial-mesenchymal transition. FASEB J 2021 Mar;35(3):e21381.

Tan X^#, Cai D^#, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W*, Wang H*. Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. Toxicol Lett. 2021 Oct 10;350:98-110.

Sun X, Wang Y, Xia B, Li Z, Dai J, Qiu P, Ma A, Lin Z, Huang J, Wang J, Xie WB*, Wang J*. Methamphetamine produces cardiac damage and apoptosis by decreasing melusin. Toxicol Appl Pharmacol. 2019 Sep 1;378:114543.

Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H, Xie WB*.CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicol Lett. 2018 Aug;292:97-107.

Xu X, Huang E, Luo B, Cai D, Zhao X, Luo Q, Jin Y, Chen L, Wang Q, Liu C, Lin Z, Xie WB*, Wang H*. Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells by activating the C/EBPβ-related signaling pathway. FASEB J.2018 Jun 25

Li B^#, Chen R^#, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB*, Wang H*. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Mol Neurobiol. 2017 Apr;54(3):1642-1660.

Du SH, Qiao DF, Chen CX, Chen S, Liu C, Lin Z, Wang H*, Xie WB*. Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes. Front Mol Neurosci. 2017 Dec 12;10:409.

Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H*, Xie WB*. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Front Mol Neurosci. 2017 Jun 26;10:203.

Chen C^#, Qincao L^#, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicol Lett. 2016 Jan 5;240(1):149-60.

Chen R^#,Wang B^#, Chen L, Cai D, Li B, Chen C, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. DNA damage-inducible transcript 4(DDIT4)mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicol Appl Pharmacol. 2016 Mar 15;295:1-11.

D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie*, H Wang*. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis. 2016 Mar 31;7(3):e2161.

Huang W^#, Xie WB^#, Qiao D^#, Qiu P^#, Huang E, Li B, Chen C, Liu C, Wang Q, Lin Z, Wang H*. Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Sci. 2015 May;145(1):68-79.

Hu ZY^#, Xie WB^#, Yang F, Xiao LW, Wang XY, Chen SY*, Li ZG*. NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling. Biochim Biophys Acta. 2015 Sep;1852(9):1876-86.

Qiao D^#, Xu J^#, Le C^#, Huang E, Liu C, Qiu P, Lin Z, Xie WB*, Wang H*. Insulin-like growth factor binding protein 5(IGFBP5)mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Lett. 2014 Nov 4;230(3):444-53.

Wei-Bing Xie^#, Zuguo Li^#, Ning Shi, Xia Guo, Junming Tang, Wenjun Ju, Jun Han, Tengfei Liu, Erwin P Bottinger, Yang Chai, Pedro A Jose, Shi-You Chen*. Smad2 and myocardin- related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res. 2013 Sep 27;113(8):e76-86.

Li Z^#, Xie WB^#, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY*. Response gene to complement 32 is essential for fibroblast activation in renal fibrosis. J Biol Chem. 2011 Dec 2;286(48): 41323-41330.

Xie WB, Li Z, Miano JM, Long X, Chen SY*. Smad3-mediated myocardin silencing:a novel mechanism governing the initiation of smooth muscle differentiation. J Biol Chem. 2011 Apr 29; 286(17):15050-7.

2. 科研项目

(1)国家自然科学基金面上项目：Nupr1介导血管稳态失衡在甲基苯丙胺相关的肺动脉高压发生中的作用及机制（编号82170438）,2022.01-2025.12, 55万, 主持，结题

(2)广东省基础与应用基础研究基金项目：Nupr1在肾纤维化发生发展中的作用及分子机制（编号2019A1515010271）,2019.10-2022.9, 10万，主持，结题

(3)国家卫生健康委员会毒品依赖和戒治重点实验室开放课题：甲基苯丙胺通过Nupr1调控STIM1/Orai钙离子通道开放诱导肺动脉高压发生（编号2020DAMOP-010），2020.8-2022.7,15万，主持，结题

(4)广州科技计划项目：甲基苯丙胺（METH）致动脉夹层发生机制及防治（编号201707010302），2017.5-2020.4， 20万，主持，结题

(5)国家自然科学基金面上项目：NDRG1在血管损伤后新生内膜形成中的作用及其分子机制（编号81370227），2014.1-2017.12，65万，主持，结题