一、基本信息

姓名：李光亚                              

职称：副教授，硕士生导师

联系邮箱： liguangya@smu.edu.cn

联系电话：020-62789355

二、学习经历

2015.9-2019.7  中国农业大学，农学，学士

2019.9-2025.1  北京大学，整合生命科学，博士

三、主要研究方向

本课题组拟围绕类器官与免疫系统的交互机制展开系统研究，重点包括：

1. 构建具备免疫调控功能的肝、肠类器官模型；

2. 运用类器官解析脂肪肝、肝纤维化，和病毒性肝炎等肝脏疾病的发生机制；

3. 发展基于类器官的药物筛选与再生治疗策略，推动类器官技术的临床转化与产业化应用。

四、主要学术任职

广东省细胞生物学学会 委员

五、主要获奖情况

1. 北京市优秀毕业生，2019

2. 国家奖学金，2019

Li G#, He J#, Shi J, Li X, Liu L, Ge X, Chen W, Jia J, Wang J, Yin M, Sakai Y, Sun W, Deng H*, Pang Y*. Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure. Gut. 2025 Mar 3:gutjnl-2024-333885.（IF=23.1）

Jiang N#, Li G#, Luo S#, Kong X, Yin S, Peng J, Jiang Y, Tao W, Li C, Xie H, Deng H*, Xie B*. Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells. Cell Mol Life Sci. 2025 Apr 6;82(1):139.（IF=6.2）

Xie H#, Li G#, Fu Y#, Jiang N, Yi S, Kong X, Shi J, Yin S, Peng J, Jiang Y, Lu S, Deng H*, Xie B*. A two-step strategy to expand primary human hepatocytes in vitro with efficient metabolic and regenerative capacities. Stem Cell Res Ther. 2024 Sep 4;15(1):281.（IF=7.1）

Shi J#, Li G#, Liu L#, Yuan X, Wang Y, Gong M, Li C, Ge X, Lu S*. Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC. Front Immunol. 2023 Apr 3;14:1166052. Frontiers in immunology, 14, 1166052.（IF=5.7）

Shi J#, Li G#, Yuan X#, Wang Y, Gong M, Li C, Ge X, Lu S*. Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration. Front Bioeng Biotechnol. 2023 Feb 23;11:1135997.（IF=4.3）

Xie B#, Sun D#, Du Y#, Jia J, Sun S, Xu J, Liu Y, Xiang C, Chen S, Xie H, Wang Q, Li G, Lyu X, Shen H, Li S, Wu M, Zhang X, Pu Y, Xiang K, Lai W, Du P, Yuan Z, Li C, Shi Y, Lu S*, Deng H*. A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts. Cell Res. 2019 Sep;29(9):696-710.（IF=28.2）

Lv Y#, Rao Z#, Liu L#, Jia J, Wu C, Xu J, Du Y, Liu Y, Liu B, Shi J, Li G, Zhao D*, Deng H*. The efficient generation of functional human hepatocytes from chemically induced pluripotent stem cells. Cell Prolif. 2024 Feb;57(2):e13540.（IF=5.9）