作者： 来源： 阅读量： 发布时间：2024-01-08 09:53:30
姓名：沈折玉（Zheyu Shen）
职称：教授
联系邮箱：sz@smu.edu.cn
学习经历（学士、硕士、博士）：
1998.09-2002.07：北京工商大学，生物化工，学士
2002.09-2008.07：中国科学院过程工程研究所，生物化工，博士
2004.10-2006.03：日本群马大学，生物材料，联合培养生
工作经历：
2008.09-2010.03：日本群马大学，医学部，博士后
2010.05-2012.04：澳大利亚阿德莱德大学，化学工程系，博士后
2012.04-2015.12：中国科学院宁波材料技术与工程研究所，副研究员，硕导
2015.12-2019.07：中国科学院宁波材料技术与工程研究所，研究员，博导
2016.07-2019.07：美国国立卫生研究院（NIH），高级访问学者
2019.08-至今：南方医科大学，教授，博导
研究方向：
磁共振成像造影剂、分子影像探针、生物医用纳米材料、肿瘤靶向诊断与治疗。
已发表SCI论文130余篇，总引用10000余次，H指数为54。
招生方向：生物材料
主要学术任职：
江苏省生物技术协会第八届理事会，特邀常务理事
广东省精准医学应用学会，分子影像分会，常务委员
中国抗癌协会纳米肿瘤学专业委员会，委员
中国医学装备协会磁共振成像装备与技术专业委员会，委员
中国医师协会介入医师分会第三届节委员会介入医学工程与生物技术学组，委员
中国抗癌协会CTC技术专家委员会，委员
主要荣誉及获奖情况：
[1]最近三年连续入选全球前2%顶尖科学家榜单（Elsevier发布）
[2] 宁波市科学技术奖，三等奖，2021年。
[3] 浙江省自然科学基金杰出青年科学基金，2018年。
[4] 宁波市科学技术奖，一等奖，2017。
[5] 宁波市领军与拔尖人才（第二层次），2017年。
[6] 中国科学院青年创新促进会会员，2016年。
期刊编委：
1) Editorial Board Member (2022-至今), Biosensors (IF=5.743)
2) Guest Editor (2021-2022), Biosensors (IF=5.743)
3) Editorial Board Member (2015-2021), International Journal of Medical Nano Research
4) Editorial Advisory Board Member (2013-2021), Biochemical and Biophysical Journal of Neutron Therapy & Cancer Treatments
主要科研课题：
[1] 胃癌铁死亡-免疫协同治疗及其反对比度磁共振成像可视化，国家自然科学基金面上项目，在研，主持。
[2] 肿瘤诊断用磁共振成像造影剂中试放大制备技术的研发，广州市重点研发计划农业和社会发展科技专题，在研，主持。
[3]介孔超顺磁性氧化铁纳米粒及其乳腺癌诊疗应用研究，广东省自然科学基金面上项目，在研，主持。
[4] 肿瘤诊断与治疗用有机无机复合纳米材料，浙江省自然科学基金杰出青年科学基金项目，已结题，主持。
[5] 癌症诊断与治疗用硼钆复合纳米粒子，国家自然科学基金国际（地区）合作与交流项目，已结题，主持。
代表性论文：
[1] Zongheng Li#, Jing Yang#, Bin Ren, Qingdeng Fan, Lin Huang, Shuai Guo, RuiLong Zhou, Sijin Chen, Jie Feng, Chenggong Yan, Xiaoyuan Chen, Zheyu Shen*. Double-Layered Hollow Mesoporous Cuprous Oxide Nanoparticles for Double Drug Sequential Therapy of Tumors. Adv. Mater. 2024, 2313212.
[2] Shuai Guo#, Zongheng Li#, Ruilong Zhou#, Jie Feng,* Lin Huang, Bin Ren, Jiaoyang Zhu,Ya Huang, Guochao Wu, Haobin Cai, Qianqian Zhang, Yushen Ke, Tianwang Guan,Peier Chen, Yikai Xu, Chenggong Yan,* Caiwen Ou,* Zheyu Shen*. MRI-guided tumor therapy based on synergy of ferroptosis, immunosuppression reversal and disulfidptosis. Small 2024, 2309842.
[3] Jianping Liu, Jiezhao Zhan, Ye Zhang, Lin Huang, Jing Yang, Jie Feng, Lingwen Ding*, Zheyu Shen*, Xiaoyuan Chen*. Ultrathin clay nanoparticles-mediated mutual reinforcement of ferroptosis and cancer immunotherapy. Adv. Mater. 2024, 36(9), 2309562.
[4] Jianping Liu, Ye Zhang, Bowei Yang, Yingbo Jia, Rui-tian Liu, Lingwen Ding*, Zheyu Shen*, Xiaoyuan Chen*. Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy. Angew. Chem. Int. Ed. 2024, 63(10), e202318530.
[5] Jing Yang, Wei Xiong, Lin Huang, Zongheng Li, Qingdeng Fan, Fang Hu, Xiaopin Duan, Junbing Fan, Bo Li, Jie Feng, Yikai Xu, Xiaoyuan Chen*, Zheyu Shen*. A Mesoporous Superparamagnetic Iron Oxide Nanoparticle as a Generic Drug Delivery System for Tumor Ferroptosis Therapy. J. Nanobiotechnol. 2024, 22, 204.
[6] Meng Shi, Wei Xiong,* Jie Feng, Lihe Wu, Jing Yang, Yudie Lu, Xuanyi Lu, Qingdeng Fan, Hemin Nie, Yunlu Dai, Chenggong Yan,* Ye Tian,* Zheyu Shen*. Kilogram Scale Facile Synthesis and Systematic Characterization of a Gd-Macrochelate as T1-Weighted Magnetic Resonance Imaging Contrast Agent. J. Nanobiotechnol. 2024, 22, 162.
[7] Lihe Wu, Xuanyi Lu, Yudie Lu, Meng Shi, Shuai Guo, Jie Feng, Sugeun Yang, Wei Xiong,* Yikai Xu, Chenggong Yan*, Zheyu Shen*. Kilogram-Scale Synthesis of Extremely Small Gadolinium Oxide Nanoparticles as a T1-Weighted Contrast Agent for Magnetic Resonance Imaging. Small 2024, 20(14), 2308547.
[8] Qingdeng Fan, Wei Xiong, Huimin Zhou, Jing Yang, Jie Feng, Zongheng Li, Lihe Wu, Fang Hu, Xiaopin Duan, Bo Li, Junbing Fan, Yikai Xu, Xiaoyuan Chen*, Zheyu Shen*. An AND logic gate for magnetic resonance imaging-guided ferroptosis therapy of tumors. Adv. Mater. 2023, 35, 2305932.
[9] Lin Huang,# Jiaoyang Zhu,# Wei Xiong, Jie Feng, Jing Yang, Xuanyi Lu, Yudie Lu, Qianqian Zhang, Peiwei Yi, Yanqiu Feng, Shuai Guo, Xiaozhong Qiu, Yikai Xu, Zheyu Shen*. Tumor-generated reactive oxygen species storm for high-performance ferroptosis therapy. ACS Nano 2023, 17, 11492-11506.
[10] Lin Huang, Yudie Lu, Shuai Guo, Jing Yang, Zhiyu Liang, Qianqian Zhang, Peiwei Yi, Yanqiu Feng, Yan Li, Yikai Xu, Xiaozhong Qiu, Jie Feng, Zheyu Shen*. A strategy of limited-space controlled aggregation for generic enhancement of drug loading capability. Adv. Funct. Mater. 2023, 33, 2209278.
[11] Yudie Lu, Zhiyu Liang, Jie Feng, Lin Huang, Shuai Guo, Peiwei Yi, Wei Xiong, Sijin Chen, Sugeun Yang, Yikai Xu, Yan Li, Xiaoyuan Chen, Zheyu Shen*. Facile synthesis of weakly ferromagnetic organogadolinium macrochelates-based T1-weighted magnetic resonance imaging contrast agents. Adv. Sci. 2023, 10, 2205109.
[12] Shuai Guo, Wei Xiong, Jiaoyang Zhu, Jie Feng, Ruilong Zhou, Qingdeng Fan, Qianqian Zhang, Zongheng Li, Jing Yang, Huimin Zhou, Peiwei Yi, Yanqiu Feng, Sugeun Yang, Xiaozhong Qiu, Yikai Xu, Zheyu Shen*. A STING pathway-activatable contrast agent for MRI-guided tumor immunoferroptosis synergistic therapy. Biomaterials 2023, 302, 122300.
[13] Jing Yang, Jie Feng*, Sugeun Yang, Yikai Xu*, Zheyu Shen*. Exceedingly small magnetic iron oxide nanoparticles for T1-weighted magnetic resonance imaging and imaging-guided therapy of tumors. Small 2023, 19(49), 2302856.
[14] Weihong Guo, Yingxin Ren, Zhian Chen, Guodong Shen, Yudie Lu, Huimin Zhou, Zhenyuan Li, Zhenhao Li, Xuanyi Lu, Guoxin Li*, Zheyu Shen*, Yanfeng Hu*. Targeted Magnetic Resonance Imaging/Near-Infrared Dual-Modal Imaging and Ferroptosis/Starvation Therapy of Gastric Cancer with Peritoneal Metastasis. Adv. Funct. Mater. 2023, 2213921.
[15] Lin Huang, Jie Feng*, Jiaoyang Zhu, Jing Yang, Wei Xiong, Xuanyi Lu, Sijin Chen, Sugeun Yang, Yan Li, Yikai Xu*, Zheyu Shen*. A strategy of Fenton reaction cycloacceleration for high performance ferroptosis therapy initiated by tumor microenvironment remodeling. Adv. Healthcare Mater. 2023, 2203362.
[16] Shuai Guo, Zongheng Li, Jie Feng, Wei Xiong, Jing Yang, Xuanyi Lu, Sugeun Yang, Yikai Xu, Aiguo Wu*, Zheyu Shen*. Cycloacceleration of ferroptosis and calcicoptosis for magnetic resonance imaging-guided colorectal cancer therapy. Nano Today 2022, 47, 101663.
[17] Huimin Zhou, Xuanyi Lu, Chao Du, Zijian Zhou,* Jie Feng, Zhiyu Liang, Yikai Xu,* Xiaozhong Qiu,* Zheyu Shen*. Cycloacceleration of reactive oxygen species generation based on exceedingly small magnetic iron oxide nanoparticles for tumor ferroptosis therapy. Small 2022, 18, 2202705.
[18] Xuanyi Lu, Huimin Zhou, Zhiyu Liang, Jie Feng, Yudie Lu, Lin Huang, Xiaozhong Qiu,* Yikai Xu,* Zheyu Shen*. Biodegradable and biocompatible exceedingly small magnetic iron oxide nanoparticles for T1-weighted magnetic resonance imaging of tumors. J. Nanobiotechnol. 2022, 20, 350.
