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陈建军

发布时间:2018年09月29日 浏览次数:

IMG_20170831_151334_543

姓名:陈建军

职称:教授(三级岗),博士生导师

联系邮箱:jchen21@smu.edu.cn

联系电话:020-62786423

 

 

学习经历:

2006.08-2011.05 美国田纳西大学,药物化学,博士

2004.05-2006.05 韩国江原国立大学,药物化学,硕士

1998.09-2003.07 沈阳药科大学 ,药学(英语),学士

 

 

工作经历:

2017.08-          南方医科大学药学院,教授

2015.08-2017.08 美国芝加哥州立大学药学院,助理/副教授 (Assistant/Associate Professor)

2014.01-2015.08 美国南方大学药学院,助理教授 (Assistant Professor)

2011.05-2013.12 美国田纳西大学,博士后

2006.08-2011.05 美国田纳西大学,研究助理

2003.07-2004.05 中国中化集团青岛公司,医药外贸与技术助理

 

 

研究方向: 肿瘤免疫小分子调节剂的发现

 

 

主要学术任职

1. 药学学报(APSB)中英文,青年编委

2. 广东省药学会-药物化学专业委员会委员

3. 广东省药理学会第二届药物筛选与评价专业委员会常务委员

4. 美国制药科学家协会(AAPS)会员

5. 美国药学院联合会(AACP) 会员

6. 美国癌症协会(AACR) 会员

7. 美国化学会(ACS) 会员

 

 

主要获奖情况:

1.  青年海外高层次人才项目,中组部, 2017

2. “New Investigator Award”,美国药学院联合会/AACP, 2016

3. “Distinguished Scholar of the Year”,美国南方大学药学院, 2015

4. “Travel award”,美国田纳西大学, 2011

5. “Travel award”,泛美色素细胞研究学会会员/PASPCR, 2009

6. “BEST-KNU fellowship”, 韩国江原国立大学, 2004

 

 

主要科研课题:

1. 国家自然科学基金面上项目:靶向PD-L1&CXCL12双功能小分子的设计、合成及作为癌症双免疫疗法的研究。2022-2025,主持 (PI)。

2. 广东省科技厅国际合作项目:靶向维生素D受体(VDR)的激动剂作为抗癌药物的研究与开发。2019-2021,主持 (PI)。

3. 广东省高水平大学建设/ 南方医科大学高层次人才引进科研启动项目。2017-2020,主持 (PI)。

4. 中组部青年海外高层次人才项目。新型小分子抗癌药物的研究。2017-2022, 主持 (PI)。

5. 美国国立卫生研究院/NIH/NIGMS, SC3, 1SC3GM122599。 Novel HIF1α Inhibitors for the Treatment of Breast Cancer。 2017-2018。 经费总额: 36万美金, 主持 (PI)。

6. 美国药学院联合会/AACP。 New Investigator Award。 Novel & Targeted Prodrug Strategy For The Treatment of Resistant Ovarian Cancer。2016.1-2016.12。 经费总额: 1万美金,主持(PI)。

7. 美国国立卫生研究院/NIH, 1S10OD016226-01A1,Mass Spectrometer for Small Molecule Drug Development。 2014.1-2014.12。 经费总额: 30万美金, 合作研究者 (Co-I)。

8. 美国国立卫生研究院/NIH, 1S10OD010678-01,Acquisition of a Q-TOF Mass Spectrometer。2012.5-2013.4。 经费总额: 32万美金, 合作研究者 (Co-I)。

 

 

论文发表:

1. Zongbao Ding, Wei Pan, Yao Xiao, Binbin Cheng*, Gang Huang*, Jianjun Chen*. Discovery of Novel 7,8-dihydropteridine-6(5H)-one-Based DNA-PK Inhibitors as Potential Anticancer Agents via Scaffold Hopping Strategy. Eur J Med Chem, 2022, April, accepted. (IF=6.514, 小类1)

2. Jin Liu, Lin Yuan, Yong Ruan, Bulian Deng, Zicao Yang, Yichang Ren, Ling Li, Ting Liu, Huiting Zhao, Ruiyao Mai, Jianjun Chen*. Novel CRBN-recruiting PROTACs as Degraders of STING With In Vivo Anti-inflammatory Efficacy. J Med Chem, 2022, April, accepted (IF=7.446, 小类1).

3. Ruiyao Mai, Bulian Deng, Huiting Zhao, Ling Li, Yuyu Fang, Siming Li, Xin Deng*, Jianjun Chen*. Design, Synthesis and Bioevaluation of Novel Enzyme Triggerable Cell Penetrating Peptide (ETCPP)-Based Dendrimers for Targeted Delivery of Camptothecin and Cancer Therapy. J Med Chem, 2022 Apr 14;65(7):5850-5865. doi: 10.1021/acs.jmedchem.2c00287. (IF=7.446, 小类1).

4. Yuanxing Zhi#, Jin Liu#, Peihua Kuang, Xin Zhang, Ziwei Xu, Yanshan Chen, Xiulin Lin, Xiaoyan Wu, Pingzheng Zhou*, Jianjun Chen*. Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses. Biochem Pharmacol. 2022 Mar 9;114988. doi: 10.1016/j.bcp.2022.114988. (IF=5.858, 小类2)

5. Ling Li#, Jin Liu#, Zichao Yang, Huiting Zhao, Bulian Deng, Yichang Ren, Ruiyao Mai, Junli Huang, Jianjun Chen*. Discovery of Thieno[2,3-d]pyrimidine-Based KRAS G12D Inhibitors as Potential Anticancer Agents via Combinatorial Virtual Screening. Eur J Med Chem., 2022, 114243. (IF=6.514, 小类1)

6. Huiting Zhao#, Ling Li#, Jin Liu, Ruiyao Mai, Jingxuan Chen, Jianjun Chen*. Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity. Bioorganic Chemistry, 2022, 121, 105652. doi.org/10.1016/j.bioorg.2022.105652 [IF=5.275, 小类1(2021升级版)].

7. Xiaopeng Peng#, Ling Li#, Jingxuan Chen#, Yichang Ren, Jin Liu, Ziwen Yu, Hao Cao, Jianjun Chen*. Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma. J Med Chem, 2022 Feb 10;65(3):2434-2457. doi.org/10.1021/acs.jmedchem.1c01863 (IF=7.446, 小类1).

8. Ling Li#, Sijie Yuan#, Lin Lin, Fang Yang, Ting Liu, Chenglong Xu, Huiting Zhao, Jingxuan Chen, Peihua Kuang, Ting Chen*, Wenzhen Liao*, Jianjun Chen*. Discovery of Novel 2-Aryl-4-Bis-amide Imidazoles (ABAI) As Anti-inflammatory Agents for the Treatment of Inflammatory Bowel Diseases (IBD). Bioorganic Chemistry, 2022, 120, 105619. doi.org/10.1016/j.bioorg.2022.105619 [IF=5.275, 小类1(2021升级版)].

9. Binbin Cheng#, Wei Pan#, Yi Xing#, Yao Xiao#, Jianjun Chen*, Zheng Xu*. Recent advances in DDR (DNA damage response) inhibitors for cancer therapy. Eur J Med Chem, 2022, February 15, 230, 114109. (IF=6.514, 小类1)

10. Zean Zhao#, Jin Liu#, Peihua Kuang#, Jian Luo, Goverdhan Surineni, Xiaolin Cen, Ting Wu, Ying Cao, Pingzheng Zhou, Jianxin Pang*, Qun Zhang*, Jianjun Chen*. Discovery of Novel Verinurad Analogs as Dual Inhibitors of URAT1 and GLUT9 with Improved Druggability for the Treatment of Hyperuricemia. Eur J Med Chem., 2022, Feb 3, 229, 114092. (IF=6.514, 小类1)

11. Yuxin Zhuang#, Guang Yang#, Shaoyu Wu, Jianjun Chen, Jiayin Guo, Dongling Quan, Tingting Zhang, Zichao Yang, Shaobin Tan, Yuheng Ji*, Zhipeng Chen*, Lin Lv*. 5-Arylalkynyl-2-Benzoyl Thiophene: A Novel Microtubule Inhibitor Exhibits Antitumor Activity without Neurological Toxicity. American Journal of Cancer Research, 2022, Jan 15, 12, 229-246. (IF=6.166, 小类2).

12. Ling Li, Yinrong Wu, Zichao Yang, Chenglong Xu, Huiting Zhao, Jin Liu, Jingxuan Chen, Jianjun Chen*. Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity. Bioorganic Chemistry, 2021 Oct 22;117:105447. doi: 10.1016/j.bioorg.2021.105447. [IF=5.275, 小类1(2020升级版);小类2(2020基础版)]

13. Yichang Ren, Yong Ruan, Binbin Cheng, Ling Li, Jin Liu, Yuyu Fang, Jianjun Chen*. Design, Synthesis and Biological Evaluation of Novel Acridine and Quinoline Derivatives as Tubulin Polymerization Inhibitors with Anticancer Activities. Bioorganic & Medicinal Chemistry, 2021 Aug 23;46:116376. doi: 10.1016/j.bmc.2021.116376. [IF=3.641, 小类2(2020升级版);小类3(2020基础版)]

14. Xiaopeng Peng#, Jingxuan Chen#, Ling Li, Zhiqiang Sun, Jin Liu, Yichang Ren, Junli Huang, Jianjun Chen*. Efficient Synthesis and Bioevaluation of Novel Dual Tubulin / Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents. J Med Chem., 2021 Jun 24;64(12):8447-8473. doi: 10.1021/acs.jmedchem.1c00413. (IF=7.446, 小类1).

15. Yichang Ren#, Yuxi Wang#, Gang Li#, Zherong Zhang, Lingling Ma, Binbin Cheng, Jianjun Chen*. Discovery of Novel Benzimidazole and Indazole Analogs as Tubulin Polymerization Inhibitors With Potent Anticancer Activities. J Med Chem., 2021 Apr 22;64(8):4498-4515. doi: 10.1021/acs.jmedchem.0c01837. (IF=7.446, 小类1)

16. Jingxuan Chen#, Ling Li#, Jin Liu, Sijie Yuan, Wenzhen Liao, Andrzej T. Slominski, Wei Li, Michał A Żmijewski, Jianjun Chen*. Discovery of Novel 3-Hydroxyandrosta-5,7-Diene-17-Carboxylic Acid Derivatives as Anti-Inflammatory Bowel Diseases (IBD) Agents. Eur J Med Chem, 2021, 220, 113468. DOI: 10.1016/j.ejmech.2021.113468. (IF=6.514, 小类1)

17. Xuchao Yang#, Binbin Cheng#, Yao Xiao#, Mingming Xue, Ting Liu, Hao Cao, Jianjun Chen*. Discovery of Novel CA-4 Analogs as Dual Inhibitors of Tubulin Polymerization and PD-1/PD-L1 Interaction for Cancer Treatment. Eur J Med Chem., 2021 Mar 5; 213:113058. doi: 10.1016/j.ejmech.2020.113058. (IF=6.514, 小类1)

18. Xin Deng, Ruiyao Mai, Chenyu Zhang, Dianbao Yu, Yichang Ren, Gang Li, Binbin Cheng, Ling Li, Zhiqiang Yu, Jianjun Chen*, Discovery of Novel Cell-penetrating and Tumor-targeting Peptide-Drug Conjugate (PDC) for Programmable Delivery of Paclitaxel and Cancer Treatment. Eur J Med Chem., 2021 Mar 5; 213:113050. doi: 10.1016/j.ejmech.2020.113050.  (IF=6.514, 小类1)

19. Gang Li, Wenqing Qi, Xiaoxun Li, Jinwu Zhao, Meihua Luo, Jianjun Chen*. Recent Advances in c-Jun N-terminal Kinase (JNK) Inhibitors. Current Medicinal Chemistry, 2021, 28(3):607-627. (IF=4.530, 小类3).

20. Xin Deng#, Ruiyao Mai#, Chenyu Zhang, Jiaqi Liu, Yichang Ren, Gang Li, Jianjun Chen*. Synthesis and pharmacological evaluation of a novel synthetic peptide CWHTH based on the Styela clava-derived natural peptide LWHTH with improved antioxidant, hepatoprotective and angiotensin converting enzyme inhibitory activities. International Journal of Pharmaceutics. 2021, 120852. doi.org/10.1016/j.ijpharm.2021.120852 [IF=5.875, 小类1(2020升级版);小类2(2020基础版)].

21. Hao Cao, Binbin Cheng, Ting Liu, Jianjun Chen*. Synthesis and Pharmacological Evaluation of Novel Resorcinol Biphenyl Ether Analogs as Small Molecule Inhibitors of PD-1/PD-L1 with Benign Toxicity Profiles for Cancer Treatment. Biochemical Pharmacology, 2021 Mar 17;188:114522. doi: 10.1016/j.bcp.2021.114522. (IF=5.858, 小类1)

22. Ling Li, Huiting Zhao, Hui Liao, Jingxuan Chen, Jin Liu, Jianjun Chen*. Discovery of Novel Quinazoline-based Covalent Inhibitors of KRAS G12C with Various Cysteine-targeting Warheads as Potential Anticancer Agents. Bioorganic Chemistry, 2021 Mar 13;110:104825. doi: 10.1016/j.bioorg.2021.104825. [IF=5.275, 小类1(2020升级版);小类2(2019基础版)].

23. Buduma Komuraiah#, Yichang Ren#, Mingming Xue, Binbin Cheng, Jin Liu, Yao Liu*, Jianjun Chen*. Design, Synthesis and Biological Evaluation of Benz-Fused Five-Membered Heterocyclic Compounds as Tubulin Polymerization Inhibitors with Anticancer Activities. Chemical Biology & Drug Design, 2021 May;97(5):1109-1116. doi: 10.1111/cbdd.13832. (IF=2.817, 小类3).

24. Hao Zhong, Pei-Ying Huang, Ping Yan, Pei-Ling Chen, Qun-Yin Shi, Ze-An Zhao , Jing-Xuan Chen, Xian Shu, Ping Wang, Bin Yang, Zheng-Zheng Zhou, Jian-Jun Chen, Jian-Xin Pang, Ying-Feng Tu, Li-Han Liu, Xian-Zheng Zhang. Versatile Nanodrugs Containing Glutathione and Heme Oxygenase 1 Inhibitors Enable Suppression of Antioxidant Defense System in a Two-Pronged Manner for Enhanced Photodynamic Therapy. Adv Healthc Mater. 2021 Jun 30;e2100770. doi: 10.1002/adhm.202100770. (IF=9.933, 小类1).

25. Yupeng Wang, Zhijian Luo, Dongfang Zhou, Xuefeng Wang, Jianjun Chen, Shipeng Gong, Zhiqiang Yu. Nano-assembly of ursolic acid with platinum prodrug overcomes multiple deactivation pathways in platinum-resistant ovarian cancer. Biomater Sci. 2021 May 5. doi: 10.1039/d1bm00087j. (IF=6.843, 1)

26. Xin Liu, Yuanyuan Yang, Mingjian Ling, Rui Sun, Meiyan Zhu, Jianjun Chen, Meng Yu, Zhenwei Peng*, Zhiqiang Yu*, Xiqiang Liu*. NearInfrared II LightTriggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors. Advanced Functional Materials. 2021, DOI: 10.1002/adfm.202101709. (IF=18.808, 1)

27. Binbin Cheng#, Yao Xiao#, Mingming Xue#, Hao Cao, Jianjun Chen*, Recent advances in the development of PD-L1 modulators: degraders, downregulators, and covalent inhibitors. J Med Chem., 2020 Dec 24; 63(24):15389-15398. DOI: 10.1021/acs.jmedchem.0c01362. (IF=7.446, 小类1)

28. Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Yingfeng Tu, Jingxuan Chen, Shuwen Liu, Xuchao Yang, Jianjun Chen*. Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment. J Med Chem., 2020 Dec 24;63(24):15946-15959. DOI: 10.1021/acs.jmedchem.0c01684. (IF=6.25, 小类1)

29. Xiaopeng Peng#, Zhiqiang Sun#, Peihua Kuang#, and Jianjun Chen*. Recent Progress on HDAC Inhibitors with Dual Targeting Capabilities for Cancer Treatment. Eur J Med Chem., 2020 Sep 12;208:112831. (IF=6.514, 小类1).

30. Jingxuan Chen, Ziyu Tang, Andrzej T. Slominski, Wei Li, Michał A Żmijewski, Yao Liu*, Jianjun Chen*. Vitamin D and its analogs as anticancer and anti-inflammatory agents. Eur J Med Chem., 2020 Aug 15;207:112738. (IF=6.514, 小类1).

31. Binbin Cheng, Yichang Ren, Wei Wang, Shuanghu Wang, Yingfeng Tu, Shuwen Liu, Jin Wang, Deying Yang, Guochao Liao, Jianjun Chen*. Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction As Potential Anticancer Agents. J Med Chem., 2020 Aug 13; 63(15):8338-8358. (IF=7.446, 小类1)

32. Xiaopeng Peng#, Zhiqiang Sun#, Peihua Kuang, Ling Li, Jingxuan Chen, Jianjun Chen*. Copper Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: A Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities. Organic Letters, 2020 Aug 7; 22(15):5789-5795. (IF=6.005, 大小类均为1)

33. Gang Li, Yuxi Wang, Ling Li, Yichang Ren, Xin Deng, Jin Liu, Wei Wang, Meihua Luo, Shuwen Liu, Jianjun Chen*. Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities. Eur J Med Chem., 2020 Sep 15; 202:112519. (IF=6.514, 小类1).

34. Binbin Cheng, Yichang Ren, Hao Cao, Jianjun Chen*. Discovery of Novel Resorcinol Diphenyl Ether-based PROTAC-like molecules as Dual Inhibitors and Degraders of PD-L1. Eur J Med Chem., 2020 Aug 1;199:112377. (IF=6.514, 小类1).

35. Xiaopeng Peng, Ling Li, Yichang Ren, Huanxin Xue, Jin Liu, Shjijun Wen, Jianjun Chen*. Synthesis of NCarbonyl Acridanes as Highly Potent Inhibitors of Tubulin Polymerization via OnePot CopperCatalyzed Dual Arylation of Nitriles with Cyclic Diphenyl Iodoniums. Advanced Synthesis and Catalysis, 2020, May 12, 362 (10), 2030-2038. (IF=5.837, 小类1).

36. Youmei Bao, Shenqi Zhang, Zeming Chen, Ann Chen, Junning Ma, Gang Deng, Weiguo Xu, Jiangbing Zhou, Zhi-Qiang Yu, Guangyu Yao*, Jianjun Chen*. Synergistic chemotherapy for breast cancer and breast cancer brain metastases via paclitaxel-loaded oleanolic acid nanoparticles. Molecular Pharmaceutics, 2020 Apr 6;17(4):1343-1351. (IF=4.939, 小类1(2020升级版);小类2(2019基础版)).

37. Wen Ma, Sui-Nan Sha, Pei-Ling Chen, Meng Yu, Jian-Jun Chen, Chao-Bo Huang, Bin Yu, Yun Liu, Li-Han Liu, Zhi-Qiang Yu. A Cell Membrane-Targeting Self-Delivery Chimeric Peptide for Enhanced Photodynamic Therapy and In Situ Therapeutic Feedback. Adv Healthc Mater. 2020 Jan;9(1):e1901100. (IF=9.933, 小类1).

38. Ling Li#,  Dongling Quan#, Jingxuan Chen, Jiahao Ding, Jinwu Zhao, Lin Lv*, Jianjun Chen*. Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents. Eur J Med Chem., 2019, Dec 15, 184:111732. (IF=6.514, 小类1).

39. Hao Cao#, Ling Li#, Deying Yang, Liming Zeng, Yewei Xie, Bin Yu*, Guochao Liao*, Jianjun Chen*, Recent Progress in Histone Methyltransferase (G9a) Inhibitors as Anticancer Agents. Eur J Med Chem., 2019 Oct 1, 179:537-546. (IF=6.514, 小类1).

40. Jingxuan Chen, Sibo Jiang, Jin Wang, Jwala Renukuntla, Suman Sirimulla and Jianjun Chen*. A Comprehensive Review of Cytochrome P450 2E1 for Xenobiotic Metabolism. Drug Metabolism Reviews. 2019 May, 51(2):178-195. (IF=4.518, 小类1 (2020升级版);小类2(2019基础版))

41. Xiaopeng Peng, Guochao Liao, Pinghua Sun, Zhiqiang Yu, Jianjun Chen*, An overview of HDAC inhibitors and their synthetic routes. Current Topics in Medicinal Chemistry, 2019, 19(12):1005-1040. (IF=3.295, 小类3)

42. Wu, Peng; Wang, Xuefeng; Wang, Zigui; Ma, Wen; Guo, Jinshan; Chen, Jianjun; Yu, Zhiqiang; Li, Jizhen; Zhou, Dongfang. Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for Dual-Drug Monitoring and Combination Therapy. ACS Appl Mater Interfaces. 2019 May 22,11(20):18691-18700. (IF=9.229, 大类1)

43. Ling Li, Sibo Jiang, Xiaoxun Li, Yao Liu, Jing Su, Jianjun Chen*, Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site, Eur J Med Chem., 2018 May 10, 151, 482-494. (IF=6.514, 小类1)

44. Xiaoxun Li, Peter D. Livant, Jianjun Chen*, An alkene-forming cascade reaction en route to 2,2'-bi(glycerol), SynLett, 2018 June 12; 29(13): 1769-1772. (IF=2.454, 小类3)

45. Binbin Cheng, Wei-En Yuan, Jing Su, Yao Liu, Jianjun Chen*, Recent Advances in Small Molecule based Cancer Immunotherapy, Eur J Med Chem., 2018 Sep 5, 157:582-598. (IF=6.514, 小类1)

46. Sibo Jiang, Yesenia L Franco, Yan Zhou, Jianjun Chen*, Nanotechnology in Retinal Drug Delivery, International Journal of Ophthalmology, 2018 Jun 18, 11(6), 1038-1044. (IF=1.779, 小类3)

47. Xiaoshuang Guo; Yuan Cheng; Xiaotian Zhao; Yanli Luo; Jianjun Chen*, Wei-En Yuan*. Advances in redox-responsive drug delivery systems of tumor microenvironment, Journal of Nanobiotechnology, 2018 Sep 22;16(1):74. (IF=10.435, 小类1)

48. Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou*, Jing Su*, Mingfeng Qiu*. Nanocrystals Technology for Pharmaceutical Science. Curr Pharm Des. 2018;24(21):2497-2507. (IF=3.116, 小类3)

49. Xiaoming Li, Xiaoshuang Guo, Yuan Cheng, Xiaotian Zhao, Zhiwei Fang, Yanli Luo, Shujun Xia, Yun Feng, Jianjun Chen*, Weien Yuan*. pH-responsive cross-linked low molecular weight polyethylenimine as an efficient gene vector for delivery of plasmid DNA encoding anti-VEGF-shRNA for tumor treatment. Frontiers in Oncology, 2018 Sep 25, 8:354. (IF=6.244, 小类2)

50. Jianjun Chen*, “Review of Design of Precursors for Sustainable Chemistry”, J. Nat. Prod., 2017, 80 (5), 1701–1702. (IF=3.2, 小类2)

51. Bin Wang, Yu Liu, Lianyan Huang, Jianjun Chen, Jing jing Li, Ruishan Wang, Eunhee Kim, Carles Justicia, Kazuko Sakata, Hao Chen, Anna Planas, Rennolds S Ostrom, Wei Li, Guang Yang, Michael P. McDonald, Ruihong Chen, Detlef Heck, and Francesca-Fang Liao, A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in Alzheimer’s mice via HSF-1 mediated mechanism. Molecular Psychiatry, (A Nature journal, Impact Factor=15,大小类均为1). 2017, 22(7): 990–1001.

52. Yanan Sun, Jing Su, Geyi Liu, Jianjun Chen, Xiumei Zhang, Ran Zhang, Minhan Jiang, Mingfeng Qiu*, Advances of blood cell-based drug delivery systems. Eur J Pharm Sci. 2017, 96:115-128. (IF=3.8, 小类2)

53. Xuelan Tang, Ping Lu, Mingfeng Qiu, Jianjun Chen, Lin Ma, Yanan Sun, Feng Zheng, Enge Xu, Jing Sheng, Jing Su, “Screening PEGylated Polyethylenimine Derivatives for Safe and Efficient Delivery of Gene Materials”, RSC Adv., 2016, 6, 106316–106326. (IF=4.0, 小类3)

54. Chuan-Ling Si, Xiao-Feng Huang, Liang-Liang An, Cui-Yun Liu, Su Fan, Dan-Ni Xie, Yi-Mei Hong,Jianjun Chen*. “Extraction and Structural Characterization of Flavonoids from Twigs of Sophora japonica”. BioResources, 10 (4), 8397-8404, (2015). (IF=1.5, 小类2)

55. Park Haeil, Chuan-Ling Si, Jianjun Chen*. “Total Synthesis of Amentoflavone”. Medicinal Chemistry, 5 (11), 467-469 (2015).

56. Elaine W. Tieu , Wei Li, Jianjun Chen, Tae-Kang Kim, Dejian Ma, Andrzej T. Slominski, and Robert C. Tuckey, “Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1”, Journal of Steroid Biochemistry and Molecular Biology, 149, 153–165, (2015). (IF=4.0, 小类2)

57. Georgina N. Masoud, Jin Wang, Jianjun Chen, Duane Miller, Wei Li. “Design, Synthesis and Biological Evaluation of Novel HIF-1α Inhibitors”. Anticancer Research, 35 (7):3849-59, (2015). (IF=2.48, 小类2)

58. Jianjun Chen, Jin Wang, Tae-Kang Kim, Elaine W Tieu, Edith Tang, Zongtao Lin, Dianne Kovacic, Duane D Miller, Arnold Postlethwaite, Robert Tuckey, Andrzej T Slominski, Wei Li, “Novel Vitamin D Analogs as Potential Therapeutics: Metabolism, Toxicity Profiling, and Antiproliferative Activity”, Anticancer Research, 34 (5), 2153-2163, (2014). (IF=2.48)

59. Jianjun Chen, Jin Wang, Luciana P. Schwab, Kyung-Tae Park, Tiffany N Seagroves, Lisa K. Jennings, Duane D. Miller, Wei Li. “Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties”, Anticancer Research, 34 (8) 3891-3904, (2014). (IF=2.48)

60. Jin Wang, Jianjun Chen, Duane D. Miller and Wei Li, “Synergistic Combinations of Novel Tubulin Inhibitors and Vemurafenib Overcome Vemurafenib Acquired Resistance in BRAFV600E Melanoma”, Molecular Cancer Therapeutics, 13, 16-26, (2014). (IF=6.2, 小类2)

61. Yan Lu, Jianjun Chen, Jin Wang, Chien-Ming Li, Sunjoo Ahn, Christina M. Barrett, James T. Dalton, Wei Li, Duane D. Miller, “Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents”, Journal of Medicinal Chemistry, 57 (17), 7355–7366, (2014). (IF=7.45, 小类1)

62. Robert C. Tuckey, Andrzej T. Slominski, Chloe Y. S. Cheng, Jianjun Chen, Tae-Kang Kim, Min Xiao and Wei Li. “Lumisterol is metabolized by CYP11A1: discovery of a new pathway”, The International Journal of Biochemistry & Cell Biology, 55, 24-34, (2014). (IF=4.6, 2)

63. Jianjun Chen, Andrzej T. Slominski, Duane D. Miller, Wei Li. “Effects of sidechain length and composition on the kinetic conversion and product distribution of vitamin D3 analogs determined by real-time NMR”, Dermato-Endocrinology, 5, 142-149, (2013). (IF=2.0)

64. Andrzej T. Slominski, Tae-Kang Kim, Michal A. Zmijewski, Zorica Janjetovic, Wei Li, Jianjun Chen, Ekaterina I. Kusniatsova, Igor Semak, Arnold Postlethwaite, Duane D. Miller, Jordan K. Zjawiony, Robert C. Tuckey. “Novel vitamin D photoproducts and their precursors in the skin”, Dermato-Endocrinology, 5, 8-19, (2013). (IF=2.0)

65. Edith K. Y. Tang, Jianjun Chen, Zorica Janjetovic, Elaine W. Tieu, Andrzej T. Slominski, Wei Li and Robert C. Tuckey. “Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1”, Drug Metabolism and Disposition, 41, 1112-1124, (2013). (IF=3.7)

66. Hovig Kouyoumdjian; David C. Zhu; Mohammad H. El-Dakdouki; Kelly Lorenz; Jianjun Chen; Wei Li; Xuefei Huang. “Glyconanoparticle Aided Detection of β-Amyloid by Magnetic Resonance Imaging and Attenuation of β-Amyloid Induced Cytotoxicity”, ACS Chemical Neuroscience, 4, 575-584, (2013). (IF=4.4)

67. Min Xiao, Sunjoo Ahn, Jin Wang, Jianjun Chen, Duane Miller, James Dalton, Wei Li. “Discovery of 4-Aryl-2-benzoyl-imidazoles As Tubulin Polymerization Inhibitor with Potent Antiproliferative Properties”, Journal of Medicinal Chemistry, 56, 3318–3329, (2013). (IF=7.45, 小类1)

68. Jianjun Chen, Sunjoo Ahn, Jin Wang, Yan Lu, James T. Dalton, Duane D. Miller, Wei Li, “Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents”, Journal of Medicinal Chemistry, 55, 7285-7289, (2012). (IF=7.45, 小类1) [本文首次报道的化合物已转让给美国 VeruPharm 公司, 目前在美国进行3项临床3/2期试验,分别治疗:(1) 晚期前列腺癌 (3: NCT04844749); (2) 新型冠状病毒COVID-19所引起的严重呼吸综合症 (3: NCT04842747)(3) 三阴性乳腺癌(2: NCT05079360); 化合物代号: VERU-111 正式名称:Sabizabulin].

69. Yan Lu, Jianjun Chen, Zorica Janjetovic, Phillip Michaels, Edith K Y Tang, Jin wang, Robert C. Tuckey, Andrzej T. Slominski, Wei Li, Duane D. Miller, "Design, Synthesis and Biological Behavior of the R-Epimer of 20-Hydroxyvitamin D3", Journal of Medicinal Chemistry, 55 (7), 3573–3577, (2012). (IF=7.45, 小类1)

70. Zhao Wang, Jianjun Chen, Jin Wang, Sunjoo Ahn, Chien-Ming Li, Yan Lu, Vivian S. Loveless, James T. Dalton, Duane D. Miller, Wei Li, “Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis”, Pharmaceutical Research, 29, 3040-3052, (2012). (IF=4.5)

71. Yan Lu, Jianjun Chen, Min Xiao, Wei Li, Duane D. Miller, “An Overview of Tubulin Inhibitors That Interact With the Colchicine Binding Site”, Pharmaceutical Research, 29, 2943-2971, (2012). (IF=4.5)

72. Elaine W. Tieu, Edith K. Y. Tang, Jianjun Chen, Wei Li, Minh N. Nguyen, Zorica Janjetovic, Andrzej Slominski and Robert C. Tuckey, “Rat CYP24A1 acts on 20-hydroxyvitamin D3 producing hydroxylated products with increased biological activity”, Biochemical Pharmacology,  84, 1696-1704, (2012). (IF=5.85)

73. Chien-Ming Li, Yan Lu, Jianjun Chen, Terrence A. Costello, Ramesh Narayanan, Mara N. Dalton, Linda M. Snyder, Sunjoo Ahn, Wei Li, Duane D. Miller, and James T. Dalton, “Orally Bioavailable Tubulin Antagonists for Paclitaxel-Refractory Cancer”, Pharmaceutical Research, 29, 3053-3063, (2012). (IF=4.5)

74. Andrzej T. Slominski, Tae-Kang Kim, Jianjun Chen, Minh N. Nguyen, Wei Li, Charles R. Yates, Trevor Sweatman, Robert C. Tuckey, "Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in the human placenta", The International Journal of Biochemistry & Cell Biology, 44, 2003-2018, (2012). (IF=4.6)

75. Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony, and Wei Li, “Human cytochrome P450scc (CYP11A1) catalyses epoxide formation with ergosterol”, Drug Metabolism and Disposition, 40, 436-444, (2012). (IF=3.7)

76. Elaine W. Tieu, Wei Li, Jianjun Chen, Donna M. Baldisseri, Andrzej T. Slominski, and Robert C. Tuckey. “Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1”, Journal of Steroid Biochemistry and Molecular Biology, 129, 163-171, (2012). (IF=4.0)

77. Jin Wang, Andrzej Slominski, Robert Tuckey, Zorica Janjetovic, Anand Kulkarni, Jianjun Chen, Arnold E. Postlethwaite, Duane Miller, Wei Li, "20-Hydroxylvitamin D3 possesses high efficacy against proliferation of cancer cells while being non-toxic", Anticancer Research,  32, 739-746, (2012). (IF=2.48)

78. Mohammad H. El-Dakdouki; David C. Zhu; Kheireddine El-Boubbou; Medha Kamat; Jianjun Chen; Wei Li; Xuefei Huang. “Development of Multifunctional Hyaluronan Coated Nanoparticles for Imaging and Drug Delivery to Cancer Cells”. Biomacromolecules, 13 (4), 1144–1151, (2012). (IF=6.98)

79. Shivaputra A. Patila, Jin Wang, Xiaochen S. Li, Jianjun Chen,Terreia S. Jones, Amira Hosni- Ahmed, Renukadevi Patil, William L. Seibel, Wei Li, and Duane D. Millera, “New Substituted 4H-Chromenes as anti-cancer agents”. Bioorganic & Medicinal Chemistry Letters, 22, 4458-4461, (2012). (IF=2.82)

80. Tae-Kang Kim, Jin Wang, Zorica Janjetovic, Jianjun Chen, Robert C. Tuckey, Minh N. Nguyen, Edith K. Y. Tang, Duane Miller, Wei Li, and Andrzej T. Slominski, "Correlation between secosteroid induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength". Molecular and Cellular Endocrinology, 361, 143-152, (2012). (IF=4.4)

81. Andrzej T. Slominski1, Tae-Kang Kim, Haleem Z. Shehabi, Igor Semak, Edith K Y Tang, Minh N. Nguyen, Heather A. E. Benson, Elena Korik, Zorica Janjetovic, Jianjun Chen, Charles R. Yates, Arnold Postlethwaite, Wei Li, Robert C. Tuckey. “In vivo evidence for novel pathway of vitamin D3 metabolism initiated by P450scc”. FASEB J, 26, 7901-7915, (2012). (IF=6.5)

82. Jianjun Chen, Chien-Ming Li, Sunjoo Ahn, Jin Wang, Zhao Wang, Yan Lu, James Dalton, Duane. D. Miller, Wei Li, “Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization”. Bioorganic & Medicinal Chemistry, 19, 4782–4795, (2011). (IF=3.6)

83. Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Duane D. Miller, and James T. Dalton, “Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-Aryl-Thiazole (SMART) and 2-Aryl-4-Benzoyl-Imidazole (ABI) for Improving Oral Bioavailability”, Drug Metabolism and Disposition, 39:1833-1839, (2011). (IF=3.7)

84. Michal A. Zmijewski, Wei Li, Jianjun Chen, Tae-Kang Kim, Jordan K. Zjawiony, , Trevor W. Sweatman, Duane D. Miller and Andrzej T. Slominski, “Synthesis and photochemical transformation of 3β, 21-dihydroxypregna-5,7-dien-20-one to biologically active products”, Steroids, 76, 193-203, (2011). (IF=2.9)

85. Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Michael Mohler, Wei Li, James Dalton, Miller, Duane, “Design, Synthesis, and SAR Studies of 4-Substituted Methoxylbenzoyl-aryl-thiazoles Analogues as Potent and Orally Bioavailable Anticancer Agents", Journal of Medicinal Chemistry, 54(13), 4678–4693, (2011). (IF=7.45, 小类1)

86. Robert C. Tuckey, Wei Li, Haleem Z. Shehabi, Zorica Janjetovic, Minh N. Nguyen, Tae-Kang Kim, Jianjun Chen, Danielle E. Howell, Heather A. E. Benson, Trevor Sweatman, Donna M. Baldisseri, and Andrzej Slominski. Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells. Drug Metabolism and Disposition, 39,1577-1588, (2011). (IF=3.7)

87. Andrzej Slominski, Wei Li, Syamal K. Bhattacharya, Richard A. Smith, Patricia Johnson, Jianjun Chen, Kathleen Nelson, Robert C Tuckey, Duane Miller, Arnold E. Postlethwaite, “Novel Vitamin D Analogues 17,20S(OH)2pD and 17,20R(OH)2pD are Noncalcemic and Show Antifibrotic Activity”, The Journal of Investigative Dermatology, 131, 1167–1169, (2011). (IF=7.2, 1)

88. Andrzej T. Slominski, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Radoslaw Bieniek, Junming Yue, Wei Li, Jianjun Chen, Minh N. Nguyen, Duane Miller, Tai C. Chen, Michael Holick, “20-hydroxyvitamin D2 is a non-calcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells”, American Journal of Physiology Cell Physiology, 300, C526-C541, (2011). (IF=4.0)

89. Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, Pavan K. Vaddady, Bernd Meibohm, James Dalton, Duane. D. Miller, Wei Li, “Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents”, Journal of Medicinal Chemistry, 53, 7414–7427, (2010). (IF=7.45, 小类1)

90. Wei Li, Jianjun Chen, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatsman, Jordan Zjawiony, Robert C Tuckey, Duane Miller, Andrzej Slominski, “Chemical Synthesis of 20S-hydroxyvitamin D3, which shows anti-proliferative activity”, Steroids, 75, 926-935, (2010). (IF=2.9)

92. Tae-Kang Kim, Jianjun Chen*(equal contribution), Wei Li, Jordan Zjawiony, Duane Miller, Zorica Janjetovic, Andrzej Slominski, “A New Steroidal 5,7-Diene Derivative, 3β-Hydroxyandrosta-5, 7-Diene-17β-Carboxylic Acid, Shows Potent Anti-proliferative Activity”, Steroids, 75(3), 230-239, (2010). Corrigendum in Steroids, 75(13-14), 1164, (2010). (IF=2.9)

93. Yan Lu, Zhao Wang, Chien-Ming Li, Jianjun Chen, James T. Dalton, Wei Li, and Duane D. Miller, “Synthesis, In Vitro Structure-Activity Relationship, and In Vivo Studies of 2-Arylthiazolidine-4-Carboxylic Acid Amides as Anticancer Agents”, Bioorganic & Medicinal Chemistry, 18(2), 477-495, (2010). (IF=3.64)

94. Jianjun Chen, Jiang-Wei Zhang, Ling Yang and Wei Li, “Structure elucidation of major metabolites from medroxyprogesterone acetate by P450”, Chemical & Pharmaceutical Bulletin, 57(8) 835-839, (2009). (IF=1.7)

95. Yan Lu, Zhao Wang, Chien-Ming Li, Jianjun Chen, James Dalton, Wei Li, Duane D. Miller, “Synthesis and SAR study of 2-aryl-thiazolidine-4-carboxamide analogues for melanoma and prostate cancer”, Journal of Medicinal Chemistry, 52, 1701-1711, (2009). (IF=7.45, 小类1)

96. Michal A. Zmijewski, Wei Li, Jordan K. Zjawiony, Trevor W. Sweatman, Jianjun Chen, Duane D. Miller and Andrzej T. Slominski, “Photo-conversion of two epimers (20R and 20S) of pregna-5, 7-diene-3β, 17α, 20-triol and their bioactivity in melanoma cells”, Steroids, 74(2), 218-228, (2008). (IF=2.9)

97. Jianjun Chen, Zhao Wang, Yan Lu, Duane D. Miller, Wei Li, “Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma”, Bioorganic & Medicinal Chemistry Letters, 18, 3183–3187, (2008). (IF=2.5)

98. Michal A. Zmijewski, Wei Li, Jordan K. Zjawiony, Trevor W. Sweatman, Jianjun Chen, Duane D. Miller and Andrzej T. Slominski, “Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives”, Photochemical & Photobiological Sciences, 7, 1570-1576, (2008). (IF=2.9)

99. Jianjun Chen, Hyeun Wook Chang, Hyun Pyo Kim and Haeil Park, “Synthesis of Phospholipase A2 Inhibitory Biflavonoids”, Bioorganic & Medicinal Chemistry Letters, 16, 2373-2375, (2006).    (IF=2.5)


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18. Compounds for treatment of cancer. JP 2016510748; US 20160015688; US 10022356; MX 2015011713; IN 2015DN08964. Wang, Jin; Chen, Jianjun; Miller, Duane D.; Li, Wei.

19. Preparation of imidazole-containing compounds and analogs useful in the treatment of cancer. KR 2016-7017425 A3; KR 2017-7006276; AU 2015202828;. Miller, Duane D.; Wei, Li; Chen, Jianjun; Dalton, James T.; Li, Chien-Ming; Ahn, Sunjoo.

20. Preparation of aryl- and heterocyclic compounds for treatment of cancer and drug-resistant tumors. IN 201718037031. Lu, Yan; Li, Chien-Ming; Wang, Zhao; Chen, Jianjun; Li, Wei; Dalton, James T.; Miller, Duane D.; Duke, Charles; Ahn, Sunjoo.

21. Aroylazole compounds as anticancer agents and their preparation and use for treatment of cancers and drug resistant cancers. US 20180093971. Lu, Yan; Li, Chien-Ming; Wang, Zhao; Chen, Jianjun; Li, Wei; Dalton, James T.; Miller, Duane D.; Duke, Charles; Ahn, Sunjoo.

22. Preparation of aryl- and heterocyclic compounds for treatment of cancer and drug-resistant tumors. JP 2017008091. Dalton, James T.; Miller, Duane D.; Ahn, Sunjoo; Chen, Jianjun; Duke, Charles; Li, Chien-Ming; Li, Wei; Lu, Yan; Wang, Zhao.

23. Enzymatic production or chemical synthesis and uses for androsta-5,7-dienes or pregna-5,7-dienes and UVB conversion products thereof. US 20140200201. Zjawiony, Jordan K.; Li, Wei; Zbytek, Blazej; Tuckey, Robert C.; Zjawiony Jordan, K.; Nguyen, Minh Ngoc; Zmijewski, Michal A.; Janjetovic, Zorica; Sweatman, Trevor W.; Miller, Duane D.; Chen, Jianjun.

24. Preparation of azole compounds for treatment of cancer. IN 201718037031. Miller, Duane D.; Li, Wei; Wang, Zhao; Lu, Yan; Chen, Jianjun; Dalton, James T.; Li, Chien-Ming.

25. Azoles and related compounds for treatment of cancer and their preparation. US 20170226086; Li, Wei; Xiao, Mi; Dalton, James; Ahn, Sunjoo; Miller, Duane D.; Chen, Jianjun; Wang, Jin.

26. Compounds for treatment of cancer. WO 2014138279; AU 2014225761; KR 2015123328. By Wang, Jin; Chen, Jianjun; Miller, Duane D.; Li, Wei.

27. Preparation of azole compounds for treatment of cancer. US 12/485,881. Miller, Duane D.; Li, Wei; Wang, Zhao; Lu, Yan; Chen, Jianjun; Dalton, James T.; Li, Chien-Ming.

28. Enzymatic production or chemical synthesis and uses for androsta-5,7-dienes or pregna-5,7-dienes and UVB conversion products thereof. US 12/807,178. Andrzej T. Slominski.; Li, Wei; Zbytek, Blazej; Tuckey, Robert C.; Zjawiony Jordan, K.; Nguyen, Minh Ngoc; Zmijewskl Michal, A.; Janjetovic, Zorica; Sweatman Trevor, W.; Miller, Duane D.; Chen, Jianjun, Postlethwaite, Arnold E.

29. Design, synthesis and biological studies of a new class of cytotoxic agents, 2-arylthiazolidine-4-carboxylic acid amides for prostate cancer, 2014.US 7,307,093; US 7,662,842; US 8,592,465; Mexico 262836; Japan 5507552; Russian Federation 2514427. Jianjun Chen, James Dalton, Duke Charles, Dongjin Hwang, Wei Li, Chien-Ming Li, Yan Lu, Duane Miller, Zhao Wang.

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