姓名：周东方

职称：教授(三级岗)，博士生导师，博士后合作导师

联系邮箱：dfzhou@smu.edu.cn

主要招生方向：药剂学、工业药学

学习经历

2008.09-2013.07 中国科学院大学，中国科学院长春应用化学研究所、高分子化学与物理专业，博士

2004.09-2008.07 中国地质大学(武汉)，材化学院，材料化学专业，学士

工作经历

2020.01-至今 南方医科大学，药学院，药剂学，教授

2016.01-2019.12 中国科学院长春应用化学研究所，高分子物理与化学国家重点实验室，副研究员

2013.07-2015.12 中国科学院长春应用化学研究所，高分子物理与化学国家重点实验室，助理研究员

研究方向

1. (金属、蛋白、多肽、基因、硼等)药物高分子材料及递送系统

2. 肿瘤及细菌、炎症相关疾病治疗

学术获奖及任职

1. 国家-青年拔尖人才(2021年)

2. 中/韩国生物材料协会青年科学家奖(2020年)、Journal of Materials Chemistry B(IF=7.571)新锐科学家(2020年)

3. The Innovation(IF=32.1)、药学学报中英文(Acta Pharmaceutica Sinica B，IF=14.5)、Asian Journal of Pharmaceutical Sciences(IF=10.2)、Chinese Chemical Letters(IF=9.1)、沈阳药科大学学报等期刊青年编委

4. Frontiers in Bioengineering and Biotechnology(IF=5.7)副主编

5. Bioactive Materials(IF=18.9)、Pharmaceutics(IF=5.4)专刊客座编辑

6. Nature Communications、Advanced Materials、Angewandte等国际高水平期刊审稿人

7. 中国人体健康科技促进会临床检验科学技术转化专业委员会委员，广东省精准医学研究会长青人智库委员会、纳米医学分会、分子影像分会委员等

承担科研项目

1. 南医科技攀峰青年人才培养专项计划A层次项目，主持，2023.12-2025.12

2. 国家-青年拔尖人才项目，主持，2022.03-2025.02

3. 国家-青年拔尖人才项目省级配套，主持，2023.03-2026.02

4. 国家自然科学基金面上项目，基于聚铂前药纳米胶束的乳腺癌细菌代谢靶向治疗研究，22275081，主持，2023.01-2026.12

5. 国家重点研发计划课题，骨关节炎生物治疗新靶点挖掘及药物新载体研制，2022YFC3601902，项目骨干，2022.12-2025.12

6. 国家重点研发计划课题，锰基复合材料诱导免疫原性细胞死亡抑制肿瘤复发，2021YFC2400602，项目骨干，2021.12-2024.11

7. 广东省基础与应用基础研究基金区域联合基金项目（重点项目），基于工程化细胞囊泡硼药递送系统的癌症协同BNCT-免疫治疗研究，2021B1515120065，联合申请人，2021.10-2024.9

8. 广州市重点研发计划-农业和社会发展科技项目，华蟾素及其白蛋白纳米制剂在鼻咽癌放疗增敏中的功能机制研究，202206010068，联合申请人，2022.04-2025.03

9. 企业横向项目，肝癌靶向纳米药物制剂研发，主持，2021.01-2022.12

10. 南方医科大学高层次人才引进科研启动项目，新型金属药物制剂，主持，2020.01-2022.12

11. 国家自然科学基金面上项目，基于含铂高分子纳米胶束的癌症CRISPR/Cas9基因编辑治疗，51773198，主持，2018.01-2021.12

12. 国家自然科学基金青年科学基金项目，逆转肿瘤顺铂耐药的两亲性嵌段配位高分子纳米胶束，51403198，主持，2015.01-2017.12

13. 中国科学院-威高研究发展计划子课题，多功能医用伤口敷料，2017004，主持，2017.03-2020.03

14. 吉林省科技厅优秀青年基金项目，主链含铂光刺激响应性高分子纳米胶束的药物控释研究，20150520019，主持，2015.01-2017.12

承担课程

1. 本科生课程：《药用高分子材料》、《药剂学》、《药学综合大实验》、《制剂设计学》、《化学生物学》

2. 研究生课程：《制剂设计学》、《分子生物药剂学》

代表性论文

1. Yupeng Wang, Jie Yu, Qiankun Shi, Zhijian Luo, Guanglong Liu, Fan Wu, Zhizhang Wang, Yubin Huang*, Dongfang Zhou*, Engineering endogenous tumor-associated macrophages-targeted biomimetic nano-RBC to reprogram tumor immunosuppressive microenvironment for enhanced chemo-immunotherapy. Advanced Materials, 2021, 33, 2103497. (IF=29.4, Inside Front Cover)

2. Zhiyun Zhang, Gaizhen Kuang, Shan Zong, Shi Liu, Haihua Xiao, Xuesi Chen, Dongfang Zhou*, Yubin Huang*, Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient post-operative prevention of tumor recurrence and metastasis. Advanced Materials, 2018, 30, 1803217. (IF=29.4)

3. Yuwei Cong^#, Haihua Xiao^#, Hejian Xiong, Zigui Wang, Jianxun Ding, Chan Li, Xuesi Chen*, Xing-Jie Liang*, Dongfang Zhou*, Yubin Huang, Dual drug backboned shattering polymeric theranostic nanomedicine for synergistic eradication of patient-derived lung cancer. Advanced Materials, 2018, 30, 1706220. (IF=29.4)

4. Haihua Xiao, Lesan Yan, Elizabeth M Dempsey, Wantong Song, Ruogu Qi, Wenliang Li, Yubin Huang, Xiabin Jing, Dongfang Zhou*, Jianxun Ding*, Xuesi Chen*, Recent progress in polymer-based platinum drug delivery systems. Progress in Polymer Science, 2018, 87, 70–106. (IF=27.1)

5. Yingjie Yu^#, Quan Xu^#, Shasha He, Hejian Xiong, Qingfei Zhang, Weiguo Xu, Lei Bai, Qi Zhang, Zhiqiang Yu, Jianxun Ding*, Haihua Xiao*, Dongfang Zhou*, Recent advances in delivery of photosensitive metal-based drugs. Coordination Chemistry Review, 2019, 387, 154–179. (IF=20.6, ESI高被引论文，热点论文)

6. Bo Yu^#, Wei Sun^#, Juntao Lin, Chaoyu Fan, Chengxingqiao Wang, Zhisen Zhang, Yupeng Wang, Yonghua Tang*, Youhui Lin*, Dongfang Zhou*, Using Cu-based metal-organic framework as a comprehensive and powerful anti-oxidant nanozyme for efficient osteoarthritis treatment. Advanced Science, 2024, 10.1002/advs.202307798. (IF=15.1)

7. Yongyan Deng^#, Yupeng Wang^#, Fan Jia, Weifeng Liu, Dongfang Zhou*, Qiao Jin*, Jian Ji, Tailoring supramolecular prodrug nano-assemblies for reactive nitrogen species-potentiated chemotherapy of liver cancer. ACS Nano, 2021, 15, 8663–8675. (IF=17.1)

8. Shasha He, Chan Li, Qingfei Zhang, Jianxun Ding, Xing-Jie Liang, Xuesi Chen, Haihua Xiao*, Xiaoyuan Chen*, Dongfang Zhou*, Yubin Huang, Tailoring platinum(IV) amphiphiles for self-targeting all-in-one assemblies as precise multimodal theranostic nanomedicine. ACS Nano, 2018, 12, 7272−7281. (IF=17.1)

9. Jun-Hui Sun^#, Xiaoling Liang^#, Manying Cai, Libiao Yan, Zhengju Chen, Lei Guo, Li Jing*, Yupeng Wang* and Dongfang Zhou*, Protein-crowned Micelles for Targeted and Synergistic Tumor-Associated Macrophages Reprogramming to Enhance Cancer Treatment. Nano Letters, 2022, 22, 4410–4420. (IF=10.8)

10. Qingfei Zhang, Gaizhen Kuang, Shasha He, Hongtong Lu, Yilong Cheng, Dongfang Zhou*, Yubin Huang*, Photoactivatable prodrug-backboned polymeric nanoparticles for efficient light-controlled gene delivery and synergistic treatment of platinum-resistant ovarian cancer. Nano Letters, 2020, 20, 3039−3049. (IF=10.8)

11. Yupeng Wang, Lina Wang, Tao Li, Min Ouyang, Hejian Xiong, Dongfang Zhou*, Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy. Acta Pharmaceutica Sinica B, 2023, 10.1016/j.apsb.2023.11.028. (IF=14.5)

12. Yupeng Wang^#, Yuwei Cong^#, Manying Cai, Lina Wang, Dongfang Zhou*, Charge-conversional click polyprodrug nanomedicine for targeted and synergistic cancer therapy. Journal of Controlled Release, 2023, 356, 567–579. (IF=10.8)

13. Xiaohui Xiao^#, Yupeng Wang^#, Jieyao Chen, Ziying Liu, Peiyao Chen, Dongfang Zhou* and Yue Pan*, Self-Targeting Platinum(IV) Prodrug Nano-Assembly as Radiosensitizer for Synergistic and Safe Chemoradiotherapy of Hepatocellular Carcinoma. Biomaterials, 2022, 289, 121793. (IF=14.0)

14. Ran Yang, Fei Chen, Jinshan Guo, Dongfang Zhou*, Shifang Luan*, Recent advances in polymeric biomaterials-based gene delivery for cartilage repair. Bioactive Materials, 2020, 5, 990−1003. (IF= 18.9)

15. Anhong Chen, Lei Wu, Yao Luo, Shaojin Lu, Yupeng Wang, Zhengzheng Zhou, Dongfang Zhou*, Zhigang Xie*, Jun Yue*, Deep tumor penetrating gold nanostars for NIR-II photothermally-induced in-situ tumor vaccination. Small, 2022, 2200993. (IF= 13.3)

16. Xueqing Xiong, Yonghua Tang, Chengjie Xu, Yupeng Wang, Yanyan Huang, Lianlian Fu, Changxu Lin, Dongfang Zhou*, Youhui Lin*, High carbonization temperature to trigger enzyme mimicking activities of silk-derived nanosheets. Small, 2020, 2004129. (IF= 13.3, Back Cover)