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周东方

发布时间:2020年01月03日 浏览次数:


姓名:周东方

职称:教授(三级岗),博士生导师,博士后合作导师

联系邮箱:dfzhou@smu.edu.cn


学习经历:

2008.09-2013.07 中国科学院大学,中国科学院长春应用化学研究所,高分子化学与物理专业,理学博士

2004.09-2008.07 中国地质大学(武汉),材化学院,材料化学专业,学士


工作经历:

2020.01-至今 南方医科大学,药学院,药剂学,教授

2016.01-2019.12 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,副研究员

2013.07-2015.12 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,助理研究员


研究方向:

1. (金属、蛋白、基因、硼等)药物高分子材料及递送系统

2. 肿瘤及细菌、病毒、炎症等相关疾病诊断治疗


获奖及学术任职:

1. 国家高层次人才特殊支持计划青年拔尖人才(2021)

2. /韩国生物材料协会2020年青年科学家奖;

3. Journal of Materials Chemistry B 期刊(IF=6.331)2020年新锐科学家;

4. Bioactive Materials期刊(IF=14.593,一区TOP)客座编辑;

5. Pharmaceutics期刊(IF=6.321)客座主编;

6. Chinese Chemical Letters、沈阳药科大学学报青年编委;

7. Nature CommunicationsAdvanced MaterialsAngewandte等三十余国际主流期刊审稿人。


科研项目:

1. 国家高层次人才特殊支持计划青年拔尖人才项目,主持,2022.01-2024.12

2. 国家重点研发计划子课题,锰基复合材料诱导免疫原性细胞死亡抑制肿瘤复发2021YFC2400602,项目骨干,2021.12-2024.11

3. 广东省基础与应用基础研究基金区域联合基金项目(重点项目),基于工程化细胞囊泡硼药递送系统的癌症协同BNCT-免疫治疗研究,2021B1515120065,联合申请人,2021.10-2024.9

4. 广州市重点研发计划-农业和社会发展科技项目,华蟾素及其白蛋白纳米制剂在鼻咽癌放疗增敏中的功能机制研究,项目骨干,2022.04-2025.03

5. 企业横向课题,肝癌靶向纳米药物制剂研发,主持,2021.01-2022.12

6. 南方医科大学高层次人才引进科研启动项目,新型金属药物制剂,主持,2020.01-2022.12

7. 国家自然科学基金面上项目,51773198,基于含铂高分子纳米胶束的癌症CRISPR/Cas9基因编辑治疗,主持,2018.01-2021.12

8. 国家自然科学基金青年科学基金项目,51403198,逆转肿瘤顺铂耐药的两亲性嵌段配位高分子纳米胶束,主持,2015.01-2017.12

9. 吉林省科技厅优秀青年基金项目,20150520019, 主链含铂光刺激响应性高分子纳米胶束的药物控释研究,主持,2015.01-2017.12

10. 中国科学院-威高研究发展计划项目子课题,2017004,多功能医用伤口敷料,主持,2017.03-2020.03


代表性论文:

1. Yupeng Wang, Jie Yu, Qiankun Shi, Zhijian Luo, Guanglong Liu, Fan Wu, Zhizhang Wang, Yubin Huang*, Dongfang Zhou*, Engineering endogenous tumor-associated macrophages-targeted biomimetic nano-RBC to reprogram tumor immunosuppressive microenvironment for enhanced chemo-immunotherapy. Advanced Materials, 2021, 33, 2103497. (IF=30.849, Inside Front Cover)

2. Zhiyun Zhang, Gaizhen Kuang, Shan Zong, Shi Liu, Haihua Xiao, Xuesi Chen, Dongfang Zhou*, Yubin Huang*, Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient post-operative prevention of tumor recurrence and metastasis. Advanced Materials, 2018, 30, 1803217. (IF=30.849)

3. Yuwei Cong, Haihua Xiao, Hejian Xiong, Zigui Wang, Jianxun Ding, Chan Li, Xuesi Chen*, Xing-Jie Liang*, Dongfang Zhou*, Yubin Huang, Dual drug backboned shattering polymeric theranostic nanomedicine for synergistic eradication of patient-derived lung cancer. Advanced Materials, 2018, 30, 1706220. (IF=30.849)

4. Yongyan Deng, Yupeng Wang, Fan Jia, Weifeng Liu, Dongfang Zhou*, Qiao Jin*, Jian Ji, Tailoring supramolecular prodrug nano-assemblies for reactive nitrogen species-potentiated chemotherapy of liver cancer. ACS Nano, 2021, 15, 8663–8675. (IF=15.881)

5. Shasha He, Chan Li, Qingfei Zhang, Jianxun Ding, Xing-Jie Liang, Xuesi Chen, Haihua Xiao*, Xiaoyuan Chen*, Dongfang Zhou*, Yubin Huang, Tailoring platinum(IV) amphiphiles for self-targeting all-in-one assemblies as precise multimodal theranostic nanomedicine. ACS Nano, 2018, 12, 72727281. (IF=15.881)

6. Qingfei Zhang, Gaizhen Kuang, Shasha He, Hongtong Lu, Yilong Cheng, Dongfang Zhou*, Yubin Huang*, Photoactivatable prodrug-backboned polymeric nanoparticles for efficient light-controlled gene delivery and synergistic treatment of platinum-resistant ovarian cancer. Nano Letters, 2020, 20, 30393049. (IF=11.189)

7. Haihua Xiao, Lesan Yan, Elizabeth M Dempsey, Wantong Song, Ruogu Qi, Wenliang Li, Yubin Huang, Xiabin Jing, Dongfang Zhou*, Jianxun Ding*, Xuesi Chen*, Recent progress in polymer-based platinum drug delivery systems. Progress in Polymer Science, 2018, 87, 70–106. (IF=29.190)

8. Yingjie Yu, Quan Xu, Shasha He, Hejian Xiong, Qingfei Zhang, Weiguo Xu, Lei Bai, Qi Zhang, Zhiqiang Yu, Jianxun Ding*, Haihua Xiao*, Dongfang Zhou*, Recent advances in delivery of photosensitive metal-based drugs. Coordination Chemistry Review, 2019, 387, 154–179. (IF=22.315, ESI高被引论文,热点论文)

9. Ran Yang, Fei Chen, Jinshan Guo, Dongfang Zhou*, Shifang Luan*, Recent advances in polymeric biomaterials-based gene delivery for cartilage repair. Bioactive Materials, 2020, 5, 990−1003. (IF= 14.593)

10. Xueqing Xiong, Yonghua Tang, Chengjie Xu, Yupeng Wang, Yanyan Huang, Lianlian Fu, Changxu Lin, Dongfang Zhou*, Youhui Lin*, High carbonization temperature to trigger enzyme mimicking activities of silk-derived nanosheets. Small, 2020, 2004129. (IF= 13.281, Back Cover)

11. Zhiyun Zhang, Shi Liu, Yanxin Qi, Dongfang Zhou*, Zhigang Xie, Xiabin Jing, Xuesi Chen, Yubin Huang*, Time-programmed DCA and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery. Journal of Controlled Release, 2016, 235, 125–133. (IF=9.776)


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