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喻志强

发布时间:2017年11月21日 浏览次数:

http://portal.smu.edu.cn/__local/D/0C/BA/A19FA78C003EA13E20B1A0ACDD2_33A9E90B_836C.jpg

姓名:喻志强

职称:教授,博士生导师,博士后合作导师

联系邮箱:yuzq@smu.edu.cn

联系电话: 18818879892

学习经历:

1995.09-1999.07湖南师范大学,化学化工学院,学士

1999.09-2002.07湖南师范大学,生物化学,硕士

2007.10-2010.09长崎大学药学院,机能性分子化学,博士

工作经历:

2002.07-2005.10中国科学技术大学生命科学学院 助教

2005.10-2006.09深圳康哲药业有限责任公司 多肽研发员

2006.10-2007.09长崎大学药学院,机能性分子化学 访学学者

2011.01-2015.07美国亚利桑那州立大学生物设计院,博士后(Research Fellow)

2015.07-至今南方医科大学药学院教授

研究方向:

1)新型靶向纳米递药系统;

2)小分子前药自组装;

3)癌症诊疗一体化;

4)中药纳米制剂;

5)美容活性多肽或中药提取物护肤品研发

主持科研课题:

1.南方医科大学高层次人才引进科研项目(C1032509) 靶向多肽或小分子糖基介导的多功能靶向给药系统的构建及其抗癌作用机制的研究(2016,01-2018,12)

2.国家自然科学基金面上项目(81541086) 基于细胞表面和线粒体双重靶向的阿霉素新型载药体系构建及肿瘤耐药逆转的研究(2016,01-2016,12) 主持

3.国家自然科学基金面上项目(81773642)多层次双细胞器靶向的新型顺铂载药体系构建及耐药研究(2018,01-2021,12) 主持

4.国家自然科学基金面上项目(52073139) 近红外二区响应性高分子纳米复合材料的构建及其性能研究(2021,01-2024,12) 主持

5.广东省粤港联合创新基金(2017A050506016),光控纳米颗粒诱发细胞自噬及其在肿瘤靶向治疗中的应用研究 (2017,01-2019,12) 共同主持

6.广东省自然科学基金面上项目(2019A1515011619) 抗癌新药斑铂载药体系构建及抗耐药机制研究(2019,10-2022,09) 主持

7.广东省自然资源厅项目项目海藻来源抗肿瘤环肽GLD规模化制备、作用机制及成药性研究(GDNRC(2020)037 (2020,01-2021,12) 共同主持

8.四川大学高分子材料工程国家重点实验室开放基金, 高分子铂前药载药体系及抗顺铂耐药研究(2018,09-2020,08) 主持

9. 高分子材料工程国家重点实验室(长春)科学基金, 高分子铂前药载药体系及抗顺铂耐药研究(2018,10-2021,09) 主持

10. 浙江省重点建设高校优势特色学科基金, 基于高分子铂药和斑蝥素载药体系构建及抗耐药性机制研究 (201810-202109) 主持

主要代表作

1.Qing Xu etal, Meng Yu*, Zhenwei Peng*, Zhiqiang Yu*, Redox-triggered NO-dependent Vasodilation and Deep Tumor Penetration for Cascade Amplified Antitumor Performance, Submitted to Nano Lett

2.Gui Chen etal, Xingjie Liang*, Zhiqiang Yu*, Meng Yu*, Glutamine antagonist synergizes with electrodynamic therapy to induce tumor regression and systemic antitumor immunity, Submitted to Adv Mater

3.Yuehua Wang etal, Aimin Li*,Meng Yu*,and Zhiqiang Yu*, CXCR4-Guided Liposomes Regulating Hypoxic and Immunosuppressive Microenvironment for Sorafenib-Resistant Tumor Treatment, submitted to Adv Sci

4.Yuanyuan Yang etal, Zhiqiang Yu*, A Cascade Targeted and Mitochondrion-Dysfunctional Nanoparticle for Overcoming Drug Resistance in Hepatocellular Carcinoma, submitting to Adv Funct Mater

5.Wen Ma#, Longguang Tang#,* etal, Zhiqiang Yu*,Targeting Neutrophils of NIR Ⅱ fluorescence imaging guided PTT combined with STING agonist against tumor metastasis, Submitting to ACS Nano

6.Zhengjie Wang etal, Zhiqiang Yu*, Phototheranostic nanoparticles with aggregation-induced emission as a four-modal imaging platform for image-guided photothermal therapy and ferroptosis of tumor cells, submitting ACS Nano

7.Zhengjie Wang etal Zhiqiang Yu*, Dynamic adjust of non-radiative and radiative attenuation of AIE molecules reinforces NIR-II imaging mediated photothermal therapy and immunotherapy, submitting

8.Minjian Ling, Longguang Tang*, Longquan Shao*,Zhiqiang Yu*,NIR-II Squaraine Dye based Nanoparticle targeting EGFR for Enhanced oral Carcinoma Theranostics,Submitting

9.X Cai, KN Wang, W Ma, Y Yang, G Chen, H Fu, C Cui*, Z Yu*, X Wang*,Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy, Journal of nanobiotechnology,2021, 19 (1), 1-13

10.Hongliang Chen et. al , Zhiqiang Yu*, Xing Zhang*, Kaijin Guo*, Biomimetic Nanotheranostics Camouflaged with Cancer Cell Membranes Integrating Persistent Oxygen Supply and Homotypic Targeting for Hypoxic Tumor Elimination, ACS Appl. Mater. Interfaces, 2021, 13 (17),19710-19725

11.Ling Yu et. al, Meng Yu*, Shijun Zhang* and Zhiqiang Yu*, Synergetic delivery of Triptolide and Ce6 with Light-activatable Liposomes for Efficient Hepatocellular Carcinoma Therapy, Acta Pharmaceutica Sinica B, 2021,11(7):2004e2015 (IF:11.84,中科院一区)

12.Yupeng Wang et.al, Jianjun Chen*, Shipeng Gong*, Zhiqiang Yu*, Nano-assembly of Ursolic Acid with Platinum Prodrug Overcomes Multiple Deactivation Pathways in Platinum-Resistant Ovarian Cancer,Biomater Sci, 2021, doi.org/10.1039/D1BM00087J

13.Xin Liu, et. al, Zhiqiang Yu*, Peng Miao*, Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA, Chem Comm, 2021, 57 (21), 2629-2632

14. Kangnan Wang et.al, Zongwan Mao*, Zhiqiang Yu*, Bin Liu*, Mitochondria as a Gate to Control Photosensitization in Nucleus, Adv Sci, 2021, 2004379 (IF:15.84,中科院一区)

15.Xin Liu#, Yuanyuan Yang#,et.al, Zhenwei Peng*, Zhiqiang Yu* Xiqiang Liu*, Near Infrared II Light Triggered Robust Carbon Radicals Generation and Hyperthermia via Azo Containing Polymers for Combined Photothermal and Thermodynamic Therapy, Adv Funct Mater, 2021, 2101709 (IF:18.836, 中科院一区)

16.K Wang, W Ma, Y Xu, X Liu, G Chen, M Yu, Q Pan, C Huang, X Li, Q Mu*,Y Sun*, Z Yu*, Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications, Chinese Chemical Letters,2020, 31 (12), 3149-3152

17.M He, L Yu, Y Yang, B Zou, W Ma, M Yu, J Lu, G Xiong*, Z Yu*, A Li*, Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models,Chinese Chemical Letters 2020, 31(12), 3178-3182

18.Longguang Tang, Zhantong Wang, Qingchun Mu, Zhiqiang Yu*, Orit Jacobson, Ling Li, Weijing Yang, Chunming Huang, Fei Kang, Wenpei Fan, Ying Ma, Maosheng Wang*, Zijian Zhou*, Xiaoyuan Chen*,Targeting Neutrophils for Enhanced Cancer Theranostics, Advanced Materials, 2020, 32 (33), 2002739 (IF:30.38,中科院一区)

19.Ma Wen#, Chen, Qiling# etal, Yu Shrike*; Ding, Jianxun*, Yu, Zhiqiang*, Self-Targeting Visualizable Hyaluronate Nanogel for Synchronized Intracellular Release of Doxorubicin and Cisplatin in Combating Multidrug-Resistant Breast Cancer, Nano Res, 2021,14, 846–857(IF 9.93,中科院大小类一区)

20.Yang Y, Yu Y, etal., Zhang X*, Xiao H*, Yu Z*, Enhanced Cisplatin Chemotherapy and Tumor Imaging with Glutathione-Scavenging NIR-II Gold Nanoclusters, ACS Nano, 2020, 14 (10), 13536-13547 (IF 15.588, 中科院大小类一区)

21.Gui Chen, Yuanyuan Yang, etal, Nan Li, Zhiqiang Yu *, Meng Yu*, Self-amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy, Nano Lett. 2020, 20(11), 8141–8150 (IF:11.34, 中科院大小类一区)

22.Y Sun, etal, L Hu*, Y Jin, H Chen, J Gong*, Z Yu*, Bifunctional and unusual amino acid β- or γ-ester prodrugs of nucleoside analogues for improved affinity to ATB0,+ and enhanced metabolic stability: An application to floxuridine, Journal of Medicinal Chemistry, 2020, 63 (19), 10816-10828(药化化学顶刊,IF 6.205,一区)

23.YuanYuan Yang etal, Xingjie Liang*, Meng Yu*, Zhiqiang Yu*, Photo-triggerable Liposomes for Repeatable and Adjustable Drug Delivery and Effective Cancer Therapy, Biomaterials, 2021, 265,120456(生物材料领域Top, IF 10.317, 中科院大小类一区)

24.G Qiao, G Chen, Q Wen, Z Yu*, Q Wang*, Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application, Journal of Colloid and Interface Science, 2020, 580, 88-98 (IF 7.489,中科院大小类二区)

25.L Yu, P He, Y Xu, X Kou, Z Yu*, X Xie, P Miao* Manipulations of DNA four-way junction architecture and DNA modified Fe3O4@ Au nanomaterials for the detection of miRNA, Sensors and Actuators B: Chemical, 2020, 128015(IF:7.1 大小类一区)

26. CX Yang, L Xing, X Chang, TJ Zhou, YY Bi, ZQ Yu*, ZQ Zhang* HL Jiang* Synergistic Platinum (II) Prodrug Nanoparticles for Enhanced Breast Cancer Therapy, Molecular Pharmaceutics, 2020, 17 (4), 1300-1309.

27.Ma W, Sha SN, Chen PL, Yu M, Chen JJ, Huang CB, Yu B, Liu Y, Liu LH*, Yu ZQ*, A Cell Membrane-Targeting Self-Delivery Chimeric Peptide for Enhanced Photodynamic Therapy and in Situ Feedback Efficacy, Adv Healthc Mater. 2020, e1901100 (IF 9.867,大类一区,小类二区)

28.Xiao YF, An FF*, Chen JX, Yu J, Tao WW, Yu Z*, Ting R, Lee CS, Zhang XH*, The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics, Small, 2019, 15(38)1903121. (IF:12.486 中科院大小类一区)

29.Peng Wu#, Xuefeng Wang#, Zigui Wang, Wen Ma, Jianjun Chen, Zhiqiang Yu*, Jizhen Li*, Dongfang Zhou*, Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for In Situ Dual-Drug Tracking and Combination Therapy, ACS Appl Mater Interfaces, 2019, 11(20), 18691-18700.(IF: 8.758 中科院大类一区)

30. Chen Q, Yang Y, Lin X, Ma W, Chen G, Li W, Wang X*, Yu Z*,Platinum(iv) prodrugs with long lipid chains for drug delivery and overcoming cisplatin resistance.. Chem Commun (Camb). 2018, 54(42):5369-5372

31.Yu Z, Schmaltz RM, Bozeman TC, Paul R, Rishel MJ, Tsosie KS, Hecht SM*. Selective tumor cell targeting by the disaccharide moiety of Bleomycin. J. Am. Chem. Soc, 2013, 135, 2883−2886

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