姓名： 陈景考

职称：副教授

联系邮箱：50155384@qq.com

联系电话：020-61648196

主要招生方向：药理学、工业药学 

学习经历：

2003.09–2007.06，中山大学，生物技术，学士

2007.09 – 2012.06，中山大学，药理学，博士

2012.7-2015.8，广州医科大学，附属第二医院神经科学研究所，博士后

工作经历：

2015/10-2017.12，中山大学药学院，特聘副研究员

2018.1-南方医科大学药学院，讲师

研究方向：

肿瘤治疗新策略

主要科研课题：

1. 国自然青年基金，81703539，靶向组蛋白去乙酰化酶和SGK1的新型大黄酸衍生物SYSUP007多靶点抗胶质瘤作用研究，2018.01-2020.12。

2. 广东省脑功能与脑疾病重点实验室开放课题基金,2016A2, AGEs/RAGE/Rho/ROCK通路在AD非特异性炎症中的作用及机制, 2016.09-2017.09。

3. 博士后科学基金，2013M542162，姜黄素通过TRPM7抑制恶性胶质瘤细胞增殖， 2013/09 - 2015/09。

4. 广州医科大学博士启动项目，2012C48，抑郁症的表观遗传学研究，2012/12 - 2014/12。

代表性论文：

(1) Chen J, Yin W, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Pi R(*): L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-kappaB inhibition and Nrf2 pathway activation. Eur J Pharmacol 2017, 806:1-9.

(2) Chen J, Sun Z, Jin M, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Pi R(*): Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-kappaB pathway. J Neuroimmunol 2017, 305:108-114.

(3) Luo L(#), Chen J(#), Su D(#), Chen M, Luo B, Pi R, Wang L, Shen W, Wang R(*).L-F001, a Multifunction ROCK Inhibitor Prevents 6-OHDA Induced Cell Death Through Activating Akt/GSK-3beta and Nrf2/HO-1 Signaling Pathway in PC12 Cells and Attenuates MPTP-Induced Dopamine Neuron Toxicity in Mice. Neurochem Res: 2017; 42:615-624.

(4) Chen J, Dou Y, Zheng X, Leng T, Lu X, Ouyang Y, Sun H, Xing F, Mai J, Gu J, Lu B, Yan G, Lin J(*), Zhu W(*): Trpm7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma. Tumour biology : 2016;37:14721-14731.

(5) Chen J，Ouyang, Ying，Cao, Lin，Zhu, Wenbo，Zhou, Yuxi，Zhou, Yuehan，Zhang, Haipeng，Yang, Xiaoxiao，Mao, Lifang，Lin, Suizhen，Lin, Jun(*) ，Hu, Jun(*)，Yan, Guangmei，Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest.，J Neurosurg Anesthesiol，2013，25（3）：285-291。

(6) Wang SN, Li Q, Jing MH, Alba E, Yang XH, Sabate R, Han YF, Pi RB, Lan WJ, Yang XB, Chen J*. Natural xanthones from garcinia mangostana with multifunctional activities for the therapy of alzheimer's disease. Neurochemical research 2016;41:1806-1817.

(7) Chen Q-H, Pi R-B, Chen J*. Pharmacology of rhein and advancement in the synthesis of its derivatives. Current Traditional Medicine 2016;2:59-69

(8) 陈秋荷, 皮荣标, 和陈景考*, 大黄酸及其衍生物:合成与药理作用研究进展. 药学研究, 2016. 35(3): p. 161-167.

(9) Li K, Tu Y, Liu Q, Ouyang Y, He M, Luo M, Chen J, Pi R, Liu A: PT93, a novel caffeic acid amide derivative, suppresses glioblastoma cells migration, proliferation and MMP-2/-9 expression. Oncol Lett 2017, 13:1990-1996

(10) Chen, Z. W., Liu, A., Liu, Q., Chen J., Li, W. M., & Chao, X. J., et al. Mef2d mediates the neuroprotective effect of methylene blue against glutamate-induced oxidative damage in ht22 hippocampal cells. Molecular Neurobiology, 2016. 1-14.

(11) Chen Z, Digiacomo M, Tu Y, Gu Q, Wang S, Yang X, Chu J, Chen Q, Han Y, Chen J, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for alzheimer's disease. European journal of medicinal chemistry 2016. 125:784-792.

(12) Tu, Y., Chen, Q., Wang, S., Uri, A., Yang, X., & Chu, J. Chen J., et al. Discovery of lipoic acid-4-phenyl-1h-pyrazole hybrids as novel bifunctional rock inhibitors with antioxidant activity. Rsc Advances.2016 6.(63)

(13) Gao, X. Y., Wang, S. N., Yang, X. H., Lan, W. J., Chen, Z. W., &Chen J., et al. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochemical Research, 2016:1-11.

(14) Chu, Jiaqi，Tu, Yalin，Chen J.，Tan, Dunxian，Liu, Xingguo，Pi, Rongbiao(*)，Effects of melatonin and its analogues on neural stem cells，Molecular & Cellular Endocrinology，2016，420：169-79。

(15) He, Mingliang，Luo, Ming，Liu, Qingyu，Chen J，Li, Kaishu，Zheng, Meiguang，Weng, Yinlun，Liu, Anmin(*)，Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy，J Neurooncol，2016，pp1-10。

(16) Hu, Haiyan，Zhou, Yuehan，Leng, Tiandong，Liu, Ailing，Wang, Youqiong，You, Xiuhua，Chen J，Tang, Lipeng，Chen, Wenli，Qiu, Pengxin，Yin, Wei，Huang, Yijun，Zhang, Jingxia，Wang, Liwei，Sang, Hanfei，Yan, Guangmei(*)，The major cholesterol metabolite cholestane-3beta,5alpha,6beta-triol functions as an endogenous neuroprotectant.，Journal of Neuroscience，2014，34（34）：11426-11438。

(17) Dou, Yunling，Li, Yuan，Chen J，Wu, Sihan，Xiao, Xiao，Xie, Shanshan，Tang, Lipeng，Yan, Min，Wang, Youqiong，Lin, Jun，Zhu, Wenbo，Yan, Guangmei，Inhibition of cancer cell proliferation by midazolam by targeting transient receptor potential melastatin 7.，Oncology Letters，2013，5（3）：1010-1016。

(18) Yang, Xiaoxiao，Li, Shifeng，Li, Wande，Chen J，Xiao, Xiao，Wang, Youqiong，Yan, Guangmei，Chen, Lijun(*)，Inactivation of lysyl oxidase by beta-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells.，Oncology Reports，2013，29（2）：541-548。

(19) Zhang, H ，Zhu, W，Su, X，Wu, S，Lin, Y，Li, J，Wang, Y，Chen J，Zhou, Y，Qiu, P，Yan, G，Zhao, S，Hu, J，Zhang, J，Triptolide inhibits proliferation and invasion of malignant glioma cells.，Journal of Neuro-Oncology，2012，109（1）：53-62。

(20) Shu, Minfeng，Zhou, Yuehan，Zhu, Wenbo，Zhang, Haipeng，Wu, Sihan，Chen J，Yan, Guangmei(*)，MicroRNA 335 is required for differentiation of malignant glioma cells induced by activation of cAMP/protein kinase A pathway.，Molecular Pharmacology，2012，81（3）：292-298。

发明专利：

1. 皮荣标， 涂亚林，文石军，王胜男，杨晓红，陈秋荷，陈景考。治疗中枢神经系统退行性疾病或脑肿瘤的化合物及其应用，中国国家发明专利申请号：201610667749.0

2. 皮荣标，颜金武，杨晓红，陈紫薇，王胜男，陈景考。咔唑-利凡斯的明二聚体及其药物组合物和应用，中国国家发明专利申请号：201610385701.0

3. 皮荣标，涂亚林，文石军，王胜男，杨晓红，陈秋荷，陈景考。治疗中枢神经系统退行性疾病的化合物及其应用。中国国家发明专利申请号：201610304191.X

4. 皮荣标；张晓；涂亚林；王胜男；杨晓红；陈秋荷；陈景考。 8-氨基喹啉-羟基咔唑杂联体，其制备方法及其药物组合物。中国国家发明专利申请号：20161103424241.3