姓名：周平正
职称：教授，博士生导师
联系邮箱：pzzhou@smu.edu.cn
联系电话：020-61648672
主要招生方向：药理学、工业药学
周平正，女，教授，博士生导师。主要研究方向为离子通道在炎症微环境，尤其是在黏膜免疫及抗病毒天然免疫中的作用及药物研发工作。以第一或通讯作者在Nat Commun、PNAS、Brit J Pharmacol和Pharmacol Res等期刊发表论文40余篇。主持国家自然科学基金国际（地区）合作项目和面上项目等国家级课题 5 项。先后入选德国洪堡学者、广东省青年珠江学者和广州市珠江科技新星等人才项目；曾获得中科院百篇优秀博士论文奖和广东省高校青年教师教学大赛二等奖。担任中国药理学会抗炎免疫药理学专委会常务委员、教学与科普专委会青年委员、广东省药理学会常务理事、广东省药理学会药物筛选与评价专委会主任委员、Pharmacol Res编委等学术任职。
学习经历：
2005.9-2009.7 南方医科大学，药学，学士
2009.9-2014.7 中科院上海药物研究所，药理学，博士
工作经历：
2014.7-2020.7 南方医科大学药学院，副教授
2015.2-2018.1 德国莱布尼兹分子药理学研究所/德国国家分子医学中心，博士后
2020.1-至今 南方医科大学药学院，神经系统与代谢疾病药物研究创新群体 执行主任
2020.8-至今 南方医科大学药学院，教授
主持科研课题：
国家自然科学基金面上项目：TWIK2钾通道调控杯状细胞黏蛋白胞吐参与炎症性肠病的作用和分子机制，2026-2029，在研
国家自然科学基金与香港研究资助局合作研究项目： TWIK2钾通道抑制剂的发现、分子机制及其作为治疗帕金森病新靶点的研究，2024-2027，在研
国家自然科学基金面上项目：体积调控型阴离子通道VRAC抑制剂的发现及其治疗脓毒症合并弥散性血管内凝血的作用与机制研究，2023-2026，在研
国家自然科学基金面上项目： VRAC通道调控NLRP3炎症小体活化的发现与机制及其作为多发性硬化症治疗新靶点的研究，2020-2023，已结题
广东省自然科学基金面上项目：肠上皮VRAC通道调控溃疡性结肠炎的发现及机制研究，2024—2026，在研
广州市重点研发项目农业和社会发展科技专题 猴耳环消炎片治疗结肠炎和结肠癌的作用与机制研究，2025-2027，在研
代表性科研论文：
Yi X*, Zhang S*, Gu X*, Wu X*, Ma L, Xu Y, Lv S, Huang J, Zhi Y, Cao Y, Cao X, Li F, Chen G, Liu S#, Yung KKL#, and Zhou P# (2026) VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation. Nat Commun doi: 10.1038/s41467-026-69963-3.
Chen Y, Zhi Y, Zhong H, Ma L, Gu X, Cai Y, Huang J, Yi X, Wu X, Yung KKL, Zhou P# (2025) Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation. Pharmacol Res. 213, 107623.
Huang J, Shi H, Shang J, Fu G, and Zhou P (2025) Ion channels of the plasma membrane and endolysosomes: Roles in osmoregulation and volume regulation in immune cells. Pharmacol Res 221:107951.
Zhong H, Cai Y, Jin J, Zhi Y, Gu X, Ye Y, Chen Z, Zhang S, Zhao B, Geng C, and Zhou P (2025) Pithecellobium clypearia Benth and malic acid protect against colitis by enhancing intestinal epithelial fucosylation and barrier function. Phytomedicine 149:157531
Luo H, Cai Y, Shi H, Ma L, Zhang S, Yung KKL, and Zhou P (2025) Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1-/- mice. Int Immunopharmacol 157:114742.
Zhou Y, Jin J, Zhou P#, Su W#, and Yao G# (2025) Adding a C-terminal amino acid prevents the conformational interconversion of plecanatide analogues. Chembiochem:e202500237
Lin X, Ma L, Huang J, Cai Y, Gu X, Chen Y, Li F, and Zhou P (2025) Midazolam negatively regulates STING trafficking and activation and protects against Listeria monocytogenes infection in vivo. Biochem Pharmacol:117096
Wu X*, Yi X*, Zhao B, Zhi Y, Xu Z, Cao Y, Cao X, Pang J, Yung KKL, Zhang S#, Liu S#, Zhou P# The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function. Pharmacol Res. 2023 23:107016.
Jiang P, Li S, Xu X, Yang C, Cheng C, Wang J, Zhou P#, Liu S#. TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation. Acta Pharmacol Sin (2023);44(4):811-821
Zhang, X., Lin, X., Luo, H., Zhi, Y., Yi, X., Wu, X., Duan, W., Cao, Y., Pang, J., Liu, S., Zhou, P# (2022) Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection. Pharmacol Res, 106112;178:106192.
Wu, XY., Lv, JY., Zhang, SQ., Yi, X., Xu, ZW., Zhi, YX., Zhao, BX., Pang, JX., Yung, K. K. L#, Liu, SW#, and Zhou, P# (2021) ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome, Acta Pharmacol Sin 43(4):992-1000
Cao Y, Chen S, Liang Y, Wu T, Pang J, Liu S#, Zhou P# (2018) Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels by beta-blocker carvedilol. British Journal of Pharmacology. 175(20):3963-3975
Zhou P, Yu H, Gu M, Nan F, Gao Z, Li M (2013) Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proceedings of the National Academy of Sciences of the United States of America 110: 8726–8731
Zhang Q*, Zhou P*, Chen Z, Li M, Jiang H, Gao Z, Yang H (2013) Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating. Proceedings of the National Academy of Sciences of the United States of America 110: 20093–20098
Zhou P*, Polovitskaya MM*, Jentsch TJ (2018) LRRC8 amino-termini influence pore properties and gating of volume-regulated VRAC anion channels. Journal of biological chemistry 293(35):13440-13451
Zhi, Y., Liu, J., Kuang, P., Zhang, X., Xu, Z., Chen, Y., Lin, X., Wu, X., Zhou, P#, Chen, J# (2022) Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses. Biochemical pharmacology 199:114988.
Zhi Y*, Wu X*, Chen Y, Chen X, Chen X, Luo H, Yi X, Lin X, Ma L, Chen Y, Cao Y, Li F, Zhou P#. A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 28; 218: 115894.
Ding L, Jiang P, Xu X, Lu W, Yang C, Li L, Zhou P#, Liu S# (2021) T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication. European journal of pharmacology 892: 173782.
Lv J, Liang Y, Zhang S, Lan, Q, Xu Z, Wu X, Kang L, Ren J; Cao Y, Wu T, Lin K, Yung, K, Cao X#, Pang J#, Zhou P# (2019) DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels. ACS Chemical Neuroscience 19;10(6):2786-2793
Ding L, Jiang P, Xu X, Lu W, Yang C, Zhou P#, Liu S#. Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB (2019) Biochem Pharmacol. 171:113691.
Xu Z, Chen Z; Wu X; Zhang L; Cao Y; Zhou P#. Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation (2020). Front. Immunol. 11:609441.
Chen S, Xu Y, Liang YM, Cao Y, Lv JY, Pang JX, Zhou P (2018) Identification and characterization of a series of novel HCN channel inhibitors. Acta pharmacologica Sinica. 40(6):746-754
Zhou P*, Zhang Y*, Xu H, Chen F, Chen X, Li X, Pi X, Wang L, Zhan L, Nan F, Gao Z (2015) P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity. Molecular pharmacology 87: 31–38
Zhou P, Babcock J, Liu L, Li M, and Gao Z. (2011) Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules. Acta Pharmacol Sin 32, 781-788
