姓名：肖计生

单位：珠江医院

职称：教授，博士生导师

联系邮箱：jsx03@163.com

主要招生方向：药剂学、工业药学

个人简介

肖计生，南方医科大学珠江医院转化医学研究中心教授、博士生导师；主要研究方向为糖尿病足伤口敷料的研发；截至目前，已在Angewandte Chemie-International Edition, Advanced Functional Materials, ACS Nano, Biomaterials, Journal of Nanobiotechnology等知名期刊发表论文16篇。已获得5项中国国家发明专利授权。在美国西北大学博士后学习期间主持项目1项 （American Heart Association Postdoctoral Fellowship）。主持国家自然科学基金面上项目2项，青年项目1项。

教育与工作经历

2021.10 ~ 至今, 南方医科大学珠江医院转化医学研究中心 教授、博导。主要研究方向：糖尿病足伤口敷料的研发。

2018.4 ~ 2021.9, 广州中医药大学 研究员、博导。主要研究方向：金属-有机框架（metal-organic framework, MOF）促进糖尿病足愈合、皮肤防护的作用、机理以及安全性评价。

2014.2 ~ 2017.10, 美国西北大学 博士后（合作导师：Guillermo Ameer 教授）。主要研究方向：金属-有机框架（metal-organic framework, MOF）促进糖尿病足愈合的作用与机制。

2008.9 ~ 2013.7, 中国科学院上海药物研究所药剂学专业理学博士（导师：李亚平 研究员）。主要研究方向：非病毒基因载体等纳米药物抑制肿瘤转移的作用与机制。

2003.9 ~ 2007.7, 中国药科大学药学专业理学学士。

科研项目

国家自然科学基金面上项目，82272153，铜-黄酮缓释系统的设计及其促进糖尿病慢性伤口愈合的机制研究 ，52万元， 主持，2023.1-2026.12

国家自然科学基金面上项目，31971321，功能化铜金属有机框架的设计及其对生殖系统毒性影响的研究，57万元，主持，2020.1-2023.12

国家自然科学基金青年项目，81801815，温敏水凝胶-金属有机框架复合物促进重症下肢缺血治疗的研究，22万元，主持，2019.1-2021.12

American Heart Association (AHA) postdoctoral fellowship，10 万美元，主持，2016.1-2017.10

发表论文

1. Chengyuan Cai,¹ Junqiao Zhua,¹ Xiaobin Huang,¹ Changda Xu, Zhenyu Wang, Tingting You, Xiao Wang, Jisheng Xiao*, Xiaopin Duan*, Hypoxia-Responsive Nanoscale Coordination Polymer Enhances the Crosstalk between Ferroptosis and Immunotherapy, Advanced Functional Materials, 2023, 10.1002/adfm.202214998. IF: 19

2. Zhenyu Wang, Tingting You, Chengyuan Cai, Qianyi Su, Jinmei Cheng, Jisheng Xiao*, Xiaopin Duan*, Biomimetic Gold Nanostructure with Virus-Like Topological Surface for Enhanced Antigen Cross-Presentation and Antitumor Immune Response. ACS Applied Materials & Interfaces, 2023 15, 11, 13929-13940 IF:9.5

3. Yao Wang, Ran Cao*, Chen Wang, Xiyu Song, Ruina Wang, Jiacun Liu, Mengmeng Zhang, Junyi Huang, Tingting You, Yihua Zhang, Dapeng Yan, Wendong Han*, Lan Yan, Jisheng Xiao*, Peng Li*, In Situ Embedding Hydrogen-Bonded Organic Frameworks Nanocrystals in Electrospinning Nanofibers for Ultrastable Broad-Spectrum Antibacterial Activity, Advanced Functional Materials, 2023, doi.org/10.1002/adfm.202214388. IF: 19

4. Jisheng Xiao,^1,* Haishan Li,¹ Wanling Zhao, Jinmei Cheng, Jiaxin Li, Xiaopin Duan,^*, Zinc-Metal-Organic Frameworks with Tunable UV Diffuse-reflectance as Sunscreens, Journal of Nanobiotechnology, 2022, 20:87. IF: 10.2

5. Yao Wang,⁺ Kaikai Ma,^*+ Jiaquan Bai, ⁺ Tao Xu, Wendong Han, Chen Wang, Zhenxia Chen, Kent O. Kirlikovali, Peng Li, ^* Jisheng Xiao,^* and Omar K. Farha^*, Chemically-Engineered Porous Molecular Coatings as Reactive Oxygen Species Generators and Reservoirs for Long-Lasting Self-cleaning Textiles, Angewandte Chemie-International Edition, 2022, 61, e202115956, IF 16.6

6. Xiaotian Ji, Yousheng Mo, Wanling Zhao, Aiqi Zhong, Xiaoying Su, Sijun Liu, Shengqing Li, Qi Wang,* Xiaopin Duan,* Jisheng Xiao*. Gender-Dependent Reproductive Toxicity of Copper Metal-Organic Frameworks and Attenuation by Surface Modification, Nanoscale, 2021, 13, 7389-7402. IF 6.7

7. Jisheng Xiao, Yunxiao Zhu, Samantha Huddleston, Peng Li, Baixue Xiao, Omar K. Farha, and Guillermo A. Ameer*. Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes, ACS Nano, 2018;12(2):1023-1032. IF 17.1

8. Jisheng Xiao, Siyu Cheng, Ji Yi, Hao Zhang, Guillermo Ameer*. A Cooperative Copper Metal–Organic Framework-Hydrogel System Improves Wound Healing in Diabetes, Advanced Functional Materials, 2017, 27(1), doi: 10.1002/adfm.201604872. IF 19

9. Xiaopin Duan¹, Jisheng Xiao¹, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*. Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram. ACS Nano 2013, 7 (7), 5858-5869. (共同第一作者) IF 17.1

10. Jisheng Xiao,¹ Xiaopin Duan¹, Zhiwen Zhang, Haijun Yu, Lingli Chen, Yaping Li*. Nanodiamonds-Mediated Doxorubicin Nuclear Delivery to Inhibit Lung Metastasis of Breast Cancer, Biomaterials 2013, 34 (37):9648-9656. IF 14

11. Jisheng Xiao, Xiaopin Duan, Qi Yin, Zehong Miao*, Haijun Yu, Chunying Chen, Zhiwen Zhang*, Jun Wang, Yaping Li*. The Inhibition of Metastasis and Growth of Breast Cancer by Blocking the NF-kB Signaling Pathway Using Bioreducible PEI-based/p65 shRNA Complex Nanoparticles. Biomaterials 2013, 34 (21):5381-5390. IF 14

12. Jisheng Xiao, Xiaopin Duan, Zhiwen Zhang, Haijun Yu, Yaping Li*. Effective Delivery of p65 shRNA by Optimized Tween 85-Polyethyleneimine Conjugate for Inhibition of Tumor Growth and Lymphatic Metastasis. Acta Biomaterialia 2014, 10 (6):2674-2683. IF 9.7

13. Jisheng Xiao, Xiaopin Duan, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*. Low Molecular Weight Polyethylenimine-Graft-Tween 85 for Effective Gene Delivery: Synthesis and in vitro Characteristics. Bioconjugate Chemistry 2012, 23 (2):222-231. IF 4.7

14. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li. Multi-targeted Inhibition of Tumor Growth and Metastasis by Disulfiram-loaded Redox-sensitive Shell Crosslinked Micelles. Nanotechnology 2014, 25:125102. IF 3.5

15. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Shirui Mao, Yaping Li*. Amphiphilic Graft Copolymer Based on Poly(styrene-co-maleic anhydride) with Low Molecular Weight Polyethylenimine for Efficient Gene Delivery. International Journal of Nanomedicine 2012, 7:4961-4972. IF 8

16. Zhiwen Zhang, Fang Gao, Huihui Bu, Jisheng Xiao, Yaping Li*. Solid Lipid Nanoparticles Loading Candesartan Cilexetil Enhance Oral Bioavailability: in vitro Characteristics and Absorption Mechanism in Rats. Nanomedicine: Nanotechnology, Biology and Medicine 2012, 8 (5):740-747. IF 5.4

已授权发明专利

1.一种能够自组装成胶束的多西他赛聚氧乙烯-聚氧丙烯-聚氧乙烯化合物，专利号：ZL201110170501.0

2.紫杉醇衍生物及其制备方法和用途，专利号：ZL201110122969.2

3.一种用作非病毒基因载体的两亲性梳状SMA-PEI接枝共聚物及其制备方法和用途，专利号：ZL201210102333.6

4.一种铜-大黄蒽醌金属有机框架复合物及其应用，202010357062.3

5.一种锌的金属有机框架ZIF-8及其应用，202010359928.4

已申请发明专利

1. 一种双硫仑-金属有机框架复合物及其制备方法和应用, 专利申请号：201811653591 .7

2. 一种锌-咖啡酸金属有机骨架复合物及其应用，202010411149.4

获奖及荣誉

1.  中国科学院 “百篇优秀博士论文”（2014）