教育经历

2013.01 – 2017.04  卡罗林斯卡医学院（瑞典），博士

2008.09 – 2010.07  哈尔滨工业大学， 硕士

2003.09 – 2007.07  哈尔滨工业大学， 本科

工作经历

2025.09 – 至今        南方医科大学， 教授

2024.06 – 2025.08  卡罗林斯卡医学院，Research Specialist

2017.05 – 2024.05  卡罗林斯卡医学院，博士后

2010.09 – 2012.12  卡罗林斯卡医学院，研究助理

研究概述

在全球范围内约有20%~30%的成年人患有慢性疼痛。由于慢性疼痛病因和机制的复杂性，阿片类药物的副作用和非阿片类药物对慢性疼痛的治疗效果有限，疼痛严重影响患者身心健康以及生活质量，给个人和社会带来巨大的经济负担。研究方向是通过解析疼痛的传递和编码机制以及不同疾病相关慢性疼痛的分子机制来开发新型镇痛药物。相关研究成果发表在Nat Neurosci、J Clin Invest和PNAS等知名期刊。

代表性文章

1. Zhang MD^#, Kupari J, Su J, Magnusson KA, Hu Y, Calvo-Enrique L, Usoskin D, Albisetti GW, Ceder MM, Henrikssson K, Leavitt AD, Zeilhofer HU, Hökfelt T, Lagerström MC, Ernfors P*. Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord. Nature Neuroscience 2025, 28(5):1012-1023

2. Su J^#, Zhang MD, Kupari J, Kwak D, Picton L, Xu B, Hu Y, Gonzalez-Alvarez G, Usoskin D, Xu Z, EI Manira A, Holmdahl R, Ernfors P*. Persistent interferon signaling that causes sensory neuron plasticity and pain in arthritis. bioRxiv preprint 2025

3. Fatt MP^#, Zhang MD, Kupari J, Altınkök M, Yang Y, Hu Y, Svenningsson P, Ernfors P*. Morphine-responsive neurons that regulate mechanical antinociception. Science, 2024, 385(6712):eado6593

4. Zhang MD^#, Su J^#, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T*, Hökfelt T*. Ca2⁺-binding protein NECAB2 facilitates inflammatory pain hypersensitivity. Journal of Clinical Investigation. 2018, 128(9):3757-3768

5. Peng C^#, Li L, Zhang MD, Bengtsson Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P*. miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science. 2017, 356(6343):1168-1171

6. Zhang MD^#*, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, Andreska T, Akassoglou K, Harkany T, Hökfelt T*, Terrando N*. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. Proc Natl Acad Sci U S A. 2016, 113(43):E6686-E6695

7. Zhang MD^#*, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovács GG, Uhlén M, Mulder J, Harkany T, Hökfelt T. Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. Brain Structure & Function. 2016, 221(7):3803-23

8. Tesoriero C^#, Codita A^#, Zhang MD^#, Cherninsky A, Karlsson H, Grassi-Zucconi G, Bertini G, Harkany T, Ljungberg K, Liljeström P, Hökfelt T*, Bentivoglio M, Kristensson K*. H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice. Proc Natl Acad Sci U S A. 2016, 113(3):E368-77

9. Zhang MD^#*, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlén M, Mulder J, Deisseroth K, Harkany T, Hökfelt T*. Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury. Proc Natl Acad Sci U S A. 2014, 111(12):E1149-58

10. Shi TJ^#*, Zhang MD^#, Zeberg H, Nilsson J, Grünler J, Liu SX, Xiang Q, Persson J, Fried KJ, Catrina SB, Watanabe M, Arhem P, Brismar K, Hökfelt T*. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model. Proc Natl Acad Sci U S A. 2013, 110(2):690-5