教育经历

2004-2008年，香港科技大学，博士学位

工作经历

2011.9- 现在 南方医科大学， 教授、博士生导师

2008.4-2011.9 香港科技大学， 博士后副研究员、研究助理教授

2003.7-2004.8 香港科技大学， 助理研究员

2000.7-2003.6 中国科学院院微生物所， 助理研究员

研究概述

主要从事精神疾病（精神分裂症、双相情感障碍和抑郁症等）复杂表型变异的表观遗传调控机制研究。依托同卵双生子队列，整合多组学数据，系统解析DNA甲基化、非编码RNA网络及RNA编辑在疾病发生中的作用；并结合小鼠模型、人源iPSC来源神经元及类脑器官开展跨尺度的功能验证，致力于揭示精神疾病的分子与神经环路机制，为精准分型与干预提供理论基础(ORCID：0000-0001-6116-4584)。

代表性文章

1. Wu, X., C. Lu, H. Kong, R. Chen, Z. Wang, Z. Deng, W. Xiao, Z. Huang, Q. Li, X. Ding, and C. Zhao*, Recalibrating the Epigenetic Clock Reveals Divergent DNA Methylation Age Signatures Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. The British Journal of Psychiatry, 2026. p.1-6 (PMID: 41877305).

2. Ye, L., C. Ni, R. Chen, S. Che, F. Xiong*, C. Zhao*, and Z. Wang*, Mendelian randomization facilitates identification of schizophrenia risk enhancer RNAs. Molecular Psychiatry, 2026.34: 2133-2143 (PMID: 41276612).

3. Ni, C., J-M. Liu, T. Yang, Z. Deng, X. Wu, S. Li, H. Xue, Z. Wang, X. Cao*, and C. Zhao*, Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449–CPLX1 Dysregulation. Schizophrenia Bulletin, 2026. 52(2): p.1-7 (PMID: 41863379).

4. Yang, T., J.-M. Liu, Q. Chen, Z. Deng, C. Ni, Y. Wang, Y. Lan, T. Jiang, S. Li, M. Jiang, H. Xue, X. Cao*, Z. Wang*, and C. Zhao*, Gain of Alternative Allele Expression of LINC02449 at rs149707223 in Schizophrenia and Bipolar Disorder: Inducing Synaptic Transmission and Behavioral Deficits in Mice. Nature Communications, 2025. 16(1): p. 9724 (PMID: 41188235).

5. Ni, C., H. Chen, Q. Chen, Y. Liao, Y. Wang, L. Ye, X. Wu, H. Ni, T. Jiang, S. Li, Q. Yang, H. Xue, Z. Wang*, F. Yi* and C. Zhao*. Allele-Specific Regulation of PAXIP1-AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice. Advanced Science (Weinh), 2025, 12(44): e08259 (PMID: 40911142).

6. Li, S., H. Ni, Y. Wang, X. Wu, J. Bi, H. Ou, Z. Li, J. Ping, Z. Wang, R. Chen, Q. Yang, M. Jiang, L. Cao, T. Jiang, S. Ren* and C. Zhao*. Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission. BMC Medicine, 2024. 22(1): 543 (PMID: 39558356).

7. Ye, J., Z. Huang, Q. Li, Z. Li, Y. Lan, Z. Wang, C. Ni, X. Wu, T. Jiang, Y. Li, Q. Yang, J. Lim, C. Ren, M. Jiang, S. Li, P. Jin, J. Chen* and C. Zhao*. Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. BMC Medicine, 2023. 21(1):491 (PMID: 38082312).

8. Liang, W., Y. Hou, W. Huang, Y. Wang, T. Jiang, X. Huang, Z. Wang, F. Wu, J. Zheng, J. Zhang, H. Ou, S. Li, J. Ping, Y. Zhang, J. Ye, Z. Li, Q. Yang, J. Zhang, X. Zheng, S. Li, X. Zhu, R. Chen* and C. Zhao*. Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission. Science Advances, 2022. 8(33): eabn7357 (PMID:35984881).

9. Li, Q., Z. Wang, L. Zong, L. Ye, J. Ye, H. Ou, T. Jiang, B. Guo, Q. Yang, W. Liang, J. Zhang, Y. Long, X. Zheng, Y. Hou, F. Wu, L. Zhou, S. Li, X. Huang, and C. Zhao*, Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function. Molecular Psychiatry, 2021. 26(11): p.6630-6642 (PMID: 33963283).

10. Ni, C., W. Jiang, Z. Wang, Z. Wang, J. Zhang, X. Zheng, Z. Liu, H. Ou, T. Jiang, W. Liang, F. Wu, Q. Li, Y. Hou, Q. Yang, B. Guo, S. Liu, S. Li, S. Li, E. Yang, X.H. Zhu, X. Huang, Z. Wen, and C. Zhao*, LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia. Molecular Psychiatry, 2021. 26(8): p.4511-4528 (PMID: 32015466).