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周美娟

职称:教授,博士生导师,博士后合作导师

职务:放射医学系主任

通信地址: 广州市广州大道北1838号南方医科大学放射医学系

办公电话:020-62789525

Email:fyzmj@163.com

扩展字段01 职称:教授,博士生导师,博士后合作导师 扩展字段02 职务:放射医学系主任
扩展字段03 通信地址: 广州市广州大道北1838号南方医科大学放射医学系 扩展字段04 办公电话:020-62789525
扩展字段05 Email:fyzmj@163.com

学术任职

中华医学会放射医学与防护专业委员会青年委员

中华预防医学会放射卫生专业委员会

广东省医学会放射防护医学分会常委兼秘书

最高学历

博士

所属科室

放射医学系

研究方向

细胞放射生物学、突发公共卫生事件应急

科研项目

miRNAs对UVB致细胞G2/M期阻滞时p53和14-3-3σ相互调控通路的调节作用及其机制 国家基金委 周美娟

MiR-664经由PI3K-Akt信号通路调节UVB辐射损伤的机制研 国家基金委 周美娟

专利

名称:一种抗皮肤鳞状细胞癌药物antagomir-365-2

申请国别:中国

申请时间:2012.06.28

获得授权时间:2013.08.21

专利号:ZL 2012 1 0219955.7

专利性质:发明专利

代表论文


1. Liu R, Zhang Q, Shen L, Chen S, He J, Wang D, Wang Q, Qi Z, Zhou M, Wang Z. Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway. Cell biology and toxicology 2020;36: 493-507.

2. He X, Gao J, Peng L, Hu T, Wan Y, Zhou M, Zhen P, Cao H. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice. Gut 2020.

3. Deng X, Zhen P, Niu X, Dai Y, Wang Y, Zhou M. APE1 promotes proliferation and migration of cutaneous squamous cell carcinoma. Journal of dermatological science 2020;100: 67-74.

4. Zhang Y, Gao L, Ma S, Ma J, Wang Y, Li S, Hu X, Han S, Zhou M, Zhou L, Ding Z. MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma. Cell death and differentiation 2019;26: 2061-73.

5. Yu C, Chen F, Jiang J, Zhang H, Zhou M. Screening key genes and signaling pathways in colorectal cancer by integrated bioinformatics analysis. Molecular medicine reports 2019;20: 1259-69.

6. Wang Y, Deng X, Dai Y, Niu X, Zhou M. miR-27a Downregulation Promotes Cutaneous Squamous Cell Carcinoma Progression via Targeting EGFR. Frontiers in oncology 2019;9: 1565.

7. Liu H, Wang H, Wu J, Wang Y, Zhao L, Li G, Zhou M. Lymphocyte nadir predicts tumor response and survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: Immunologic relevance. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2019;131: 52-9.

8. Li X, Zhou C, Zhang C, Xie X, Zhou Z, Zhou M, Chen L, Ding Z. MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2. Journal of dermatological science 2019;94: 330-8.

9. Huang J, Qi Z, Chen M, Xiao T, Guan J, Zhou M, Wang Q, Lin Z, Wang Z. Serum amyloid A1 as a biomarker for radiation dose estimation and lethality prediction in irradiated mouse. Annals of translational medicine 2019;7: 715.

10. Zhou L, Wang Y, Zhou M, Zhang Y, Wang P, Li X, Yang J, Wang H, Ding Z. HOXA9 inhibits HIF-1alpha-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development. Nature communications 2018;9: 1480.

11. Ding Z, Jian S, Peng X, Liu Y, Wang J, Zheng L, Ou C, Wang Y, Zeng W, Zhou M. Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2. Medicine 2015;94: e1327.

12. Zhou M, Zhou L, Zheng L, Guo L, Wang Y, Liu H, Ou C, Ding Z. miR-365 promotes cutaneous squamous cell carcinoma (CSCC) through targeting nuclear factor I/B (NFIB). PloS one 2014;9: e100620.

13. Zhou M, Liu W, Ma S, Cao H, Peng X, Guo L, Zhou X, Zheng L, Guo L, Wan M, Shi W, He Y, et al. A novel onco-miR-365 induces cutaneous squamous cell carcinoma. Carcinogenesis 2013;34: 1653-9.