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查龙应

职 称:教授 博导/博士后合作导师

职务:营养与食品卫生学系党支部书记、系副主任

通信地址:广州大道北1838号南方医科大学公共卫生学院营养与食品卫生学系

Email:lyzha@smu.edu.cn

办公电话:020-61648309

扩展字段01 职 称:教授 博导/博士后合作导师 扩展字段02 职务:营养与食品卫生学系党支部书记、系副主任
扩展字段03 通信地址:广州大道北1838号南方医科大学公共卫生学院营养与食品卫生学系 扩展字段04 Email:lyzha@smu.edu.cn
扩展字段05 办公电话:020-61648309

学术任职

中国营养学会理事

广东医学微量元素学会理事长

广东省营养学会副理事长

广东省营养学会青年工作委员会副主任委员

广东省营养学会营养与慢病管理专业委员会常务委员

广东省健康管理学会食品安全与营养健康专业委员会常务委员

美国营养学会会员

北美华人营养学会会员

中国生物化学与分子生物学会会员

中国营养学会营养与组学技术分会委员

中国营养学会营养与保健食品分会委员

中华预防医学会自由基专业委员会委员

研究方向

慢性代谢性疾病分子机制及其膳食营养防治

讲授课程

营养与食品卫生学;Nutrition & Food Hygiene (全英课程);Hygienics(全英课程);预防医学导论;社区营养学、食品加工与保藏原理;食品理化检验;食品安全标准与质量控制;卫生学;人文与社会医学四;食物营养与健康(研究生课程);环境健康科学概论(研究生课程)

科研项目

1. 国家自然科学基金面上项目(No.82373554),基于调控Akkermansia muciniphila及其胞外囊泡探究大豆皂苷A1预防非酒精性脂肪性肝炎活性的机理,2024.01-2027.12,49万元。

2. 国家自然科学基金面上项目(No.82073532),巨噬细胞外泌体及其miR-3064-5p经调控NF-κB信号通路介导棕榈酸产生代谢性炎症的作用与机制研究,2021.01-2024.12,56万元。

3. 国家自然科学基金面上项目(No.81872621),大豆皂甙经调控肝脏-胆汁酸-肠道菌群代谢轴预防非酒精性脂肪肝病活性与机理研究,2019.01-2022.12,58万元。

4. 国家自然科学基金面上项目(No.81573125),大豆皂甙调控TLR4信号通路关键靶点的发现及其抗慢性炎症机理,2016.01-2019.12,50万元。

5. 国家自然科学基金青年项目(No.81102130),大豆皂甙经调节NF-κB信号通路抗慢性炎症的机理研究,2012.01-2014.12,23万元。

6. 广东省自然科学基金面上项目(No.2023A1515011614),大豆皂苷经调控DDX5-TSC1/2-mTORC1- 自噬信号轴预防非酒精性脂肪肝炎的分子机制研究,2023.01-2026.01,10万元。

7. 广东省自然科学基金面上项目(No.2014A030313313),大豆皂甙调控TLR4信号通路关键靶点的发现及其抗慢性炎症机理,2015.01-2018.01,10万元。

8. 广东省医学科学技术研究基金(No.A2011357),基于NF-κB调控的大豆皂甙抗炎性作用构效关系及机制研究,2011.10-2013.10,1万元。

9. 广东省医学科学技术研究基金(No.B2008104),大豆皂甙对促癌剂抑制细胞间隙连接通讯的拮抗作用研究,2008.01-2009.12,1万元。

10.安利科学研究基金(No.Am20220316TR),人参皂苷降脂活性的个性化营养干预研究,2022.12-2024.12, 30万元。

代表论文

.Chuhong Su, Jiexian Wang, Huiyu Luo, Junbin Chen, Fengjuan Lin, Jiaqi Mo, Fei Xiong, Longying Zha*. Gut Microbiota Plays Essential Roles in Soyasaponin’s Preventive Bioactivities Against Steatohepatitis in the Methionine and Choline Deficient (MCD) Diet-induced Nonalcoholic Steatohepatitis (NASH) Mice. Molecular Nutrition and Food Research. 2024, Jan 17, 68(4): e2300561. DOI: 10.1002/mnfr.202300561.

2. Zhongdaixi Zheng, Jiaqi Mo, Fengjuan Lin, Jiexian Wang, Junbin Chen, Huiyu Luo, Yuguo Liu, Chuhong Su, Xiangfu Gu, Fei Xiong, and Longying Zha*. Milk Exosomes from Gestational Diabetes Mellitus (GDM) and Healthy Parturient Exhibit Differential miRNAs Profiles and Distinct Regulatory Bioactivity on Hepatocyte Proliferation. Molecular Nutrition and Food Research. 2023, Aug 23, 67(16): e2300005. DOI: 10.1002/mnfr.202300005.

3. Li B, Li W, Liu TC*, Zha LY. Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases. Frontiers in Molecular Biosciences, 2023 Jan 9; 9: 1024786. DOI: 10.3389/fmolb.2022.1024786.

4. Huiyu Luo, Junbin Chen, Chuhong Su, Longying Zha*. Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis. Nutrients, 2022 (Nov 24), 14(23): 4998. DOI: 10.3390/nu14234998.

5. Huiyu Luo, Gan Li, Yuguo Liu, Yuanhao Wei, Junbin Chen, Xiangfu Gu, Jiaqi Tang, Yue Zhao, Chuhong Su, Lingyu Xiao, Fei Xiong, Zhongdaixi Zheng, Shiying Wang, Longying Zha*. The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes. Current Issues in Molecular Biology, 2022(Oct 13), 44(10): 4822-4837. 2.

6. Junbin Chen, Yuguo Liu, Huiyu Luo, Guoxun Chen, Zhongdaixi Zheng, Tiannan Wang, Xinge Hu, Yue Zhao, Jiaqi Tang, Chuhong Su and Longying Zha*. Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells. Pharmaceuticals, 2022 (30 June), 15, 813. DOI: 10.3390/ph15070813.

7. Xiangfu Gu#, Jiaqi Tang#, Yue Zhao#, Chuhong Su, Lingyu Xiao, Huiyu Luo, Yuguo Liu, Fei Xiong, Zhongdaixi Zheng, Junbin Chen, Longying Zha*. Soyasaponin A1 inhibits the lipid raft recruitment and dimerization of TLR4, MyD88, and TRIF by maintaining cholesterol homeostasis in palmitic acid-stimulated inflammatory Raw264.7 macrophage cell line. Journal of Functional Foods, 2021 (Nov), 87: 104789. DOI:10.1016/j.jff.2021.104789.

8. Fei Xiong#, Zhongdaixi Zheng#, Lingyu Xiao#, Chuhong Su, Junbin Chen, Xiangfu Gu, Jiaqi Tang, Yue Zhao, Huiyu Luo, Longying Zha*. Soyasaponin A2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline Deficient (MCD) Diet-induced Non-alcoholic Steatohepatitis (NASH) Mice. Molecular Nutrition and Food Research, 2021 (July 21), 65(14): e2100067, DOI: 10.1002/mnfr.202100067.

9. Chen JB#, Ullah H#, Zheng Z#, Gu XF, Su CH, Xiao LY, Wu XL, Xiong F, Li Q*, Zha LY*. Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts. BMC Complementary Medicine and Therapies, 2020 (Jun 3), 20: 167. DOI: 10.1186/s12906-020-2864-2.

10. Xie Q#, Xiong F#, Wu X#, Chen J, Gu X, Su C, Xiao L, Zheng Z, Wei Y, Ullah H, Zha LY*. Soyasaponin A1 and A2 exert anti-atherosclerotic functionality by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed apoE-/- mice. Food and Function, 2020 (Jan 29), 11: 253. DOI: 10.1039/C9FO02654A.

11. Guo Yi, Zhang Peiwen, Liu Yongji, Zha Longying, Ling Wenhua, Guo Honghui*. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition, 2020 (June), 74: 110745.

12. Xuebin Gao, Dinghe Zhu, Yongji Liu, Longying Zha, Dixin Chen, Honghui Guo*. Physicochemical properties and anthocyanin bioaccessibility of downy rose-myrtle powder prepared by superfine grinding. International Journal of Food Properties, 2019, 22(1): 2022-2032.

13. Iboyi AJK*, Zha LY. Severe acute malnutrition (SAM) evaluation of associated risk factors, screening tools, and therapeutic management among South Sudanese children aged 6-59 months in emergency settings: case reports and review of literature. Journal of Tropical Diseases, 2019, 7(2): 1000298.

14. Chai SC, Davis K, Zhang Z, Zha LY, Kirschner KF*. Effects of tart cherry juice on biomarkers of inflammation and oxidative stress in older adults. Nutrients, 2019, 11(2): pii: E228. DOI: 10.3390/nu11020228.

15. Xie QY#, Gu XF#, Chen JB#, Liu MS, Xiong F, Wu XL, Zhang YJ, Chen FP, Chen HE, Li MJ, Sun SX, Chu XW, Zha LY*. Soyasaponins reduce inflammation and improve serum lipid profiles and glucose homeostasis in high fat diet-induced obese mice. Molecular Nutrition and Food Research, 2018 (Oct 1), 62(19): e1800205 (DOI: 10.1002/mnfr.201800205).

16. Bili AAM, Zha LY*. Knowledge of type 2 diabetes mellitus and adherence to management guidelines: a cross-sectional study in Juba, South Sudan. South Sudan Medical Journal, 2018, 11 (4): 84-88.

17. Zhang YJ, Chen FP, Chen JD, Huang SQ, Chen JB, Huang J, Li N, Sun SX, Chu XW, Zha LY*. Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species. Molecular Nutrition and Food Research, 2016 (Jul 8), 60(7): 1532-1543. DOI: 10.1002/mnfr.201600015.

教材著作

1. 参编(2.7/85万字)《老年健康信息咨询师培训教材》,朱惠莲、高松柏主编,北京:中国轻工业出版社,2022年11月,ISBN: 978-7-5184-4077-1。

2. 参编(1.5万字/93.5万字)全英文教材《预防医学(Preventive Medicine)》,赵进顺、倪春辉、孟晓静主编,杭州:浙江大学出版社,2020年7月,ISBN: 978-7-308-20295 4。

3. 参编(3.7万字/39.2万字)国家级实验教学示范中心教材、全国高等院校规划教材《食品安全综合实习指导》,毛丽梅主编,北京:科学出版社,2013年2月,ISBN: 978-7-030-366252。

成果奖励

2023.06.26,援外公共卫生硕士项目2022-2023年度最受欢迎课程《Nutrition & Food Hygiene》

2021.11,“广东省全民营养周活动连续六届特殊贡献个人”荣誉称号

2020.11,广东省营养学会全民营养周“特别贡献奖”

2019.11,第五届广东省全民营养周活动“优秀个人”

2019.08,第十届“南医优秀教师”

2019.06,南方医科大学公共卫生学院“优秀班主任”

2019.05.18,指导学生参加第二届全国大学生公共卫生综合知识与技能大赛获得“优秀参赛奖”

2018.01.22,南方医科大学2016-2017学年教学优秀二等奖

2018.01.14,广东省营养学会2017年年会学术交流优秀论文二等奖

2018.01.14,广东省第三届全民营养周活动“突出贡献个人”

2016.11.19,广东省第一届中青年教师公共卫生与预防医学本科课程教学竞赛一等奖

2015.12.17,南方医科大学第五届中青年教师本科课程教学竞赛双语组三等奖