师资队伍

中南大学医学硕士，中山大学医学博士

环境卫生学系

环境与健康；水处理技术；干细胞源性EVs修复技术

《环境卫生学》、《卫生学》、《预防医学导论》、《环境与健康》

1.主持国家自然科学基金面上项目:苯转化的恶性细胞外泌体miR-221 在细胞增殖和凋亡抑制信号传导中的作用及机制；

2.主持国家生态环境部项目：汽油添加剂甲基叔丁基醚（MTBE）污染特征、人群健康风险评估及管理对策研究；

3.主持广州市重点科技项目：基于库区土著生物的慢性毒性快速识别及毒物追踪关键技术研发；

4.主持广东省科技计划项目:替莫唑胺化疗耐药干预的分子靶标研究；

5.主持广东省科技计划项目：北江水系佛山东平河饮用水源及城区自来水微囊藻毒素污染及对策研究；

6.主持广东省科技计划项目：矽肺基因治疗关键技术研究；

7. 主持完成深圳市科技创新项目JCYJ2016XXXX11104XXX 、JCYJ2016XXXX173527XXX 、JCYJ2017XXXX162947XXX 等；

8.主持广东省医学科学基金项目：佛山陶瓷企业石英粉尘的人群潜在性损伤及其流行病学干预研究；

9.主持佛山市重点科技攻关项目：佛山市大气环境TSP 污染及其有机关键毒性组份的人体安全性研究；

10．主持完成佛山市重点科技攻关项目：RNA 干扰技术在矽肺基因治疗中的运用研究；

11.主持完成佛山市科技攻关项目：佛山市饮用水源及城区自来水中环境雌激素污染的流行病学研究；

11. 参与“ 973 ” 国家重点基础研究发展计划基金资助项目的研究（ 2002CB512904 ；2002CB512903）；

12.参与国家自然科学基金项目：利用人工锌指核酸酶的高效多位点基因打靶研究。

(1) Chen Y, Hu Z, Tang M, Huang F, Xiong Y, Ouyang D, He J, He S, Xian H, Hu D. Lysosome-related exosome secretion mediated by miR-26b / Rab31 pathway was associated with the proliferation and migration of MCF-7 cells treated with BPA. Ecotoxicol Environ Saf. 2023 Mar 1;252:114563.（Ecotoxicology and Environmental Safety, IF=6.8, 1 区).

(2) Tang M, Chen Y, Xian H, Tan S, Lian Z, Peng X, Hu D. Circulating exosome level of indigenous fish may be a novel biomarker for the integrated ecotoxicity effect of water environment.Ecotoxicol Environ Saf. 2022 Jan 1;229:113084. （Ecotoxicology and Environmental Safety, IF=6.8,1 区).

(3) Xian HY, Chen Y, Zhang JY, Tang ML, Lian ZW, Jiang R, Hu ZQ, Li YF, Hu DL. Exosomes Derived from Hydroquinone-transformed Human Bronchial Epithelial Cells Inhibited Recipient Cell Apoptosis by transferring miR-221. Biomed Environ Sci. 2021 Jul 20;34(7):520-527. (Biomedical and Environmental Sciences, IF=3.5, 3 区)

(4) Xian H, Tang M, Chen Y, Lian Z, Li Y, Peng X, Hu D. Indigenous Fish-Based Assessment of Genotoxic Potentials of the Helong Reservoir in Guangzhou, China. Environ Toxicol Chem. 2021 Jul;40(7):1919-1927. (Environmental Toxicology and Chemistry, IF=4.1, 4 区)

(5) He Z, Li Y, Lian Z, Liu J, Xian H, Jiang R, Hu Z, Fang D, Hu D. Exosomal secretion may be a self-protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone. J Appl Toxicol. 2021 Feb;41(2):265-275.（Journal of Applied Toxicology, IF=3.3, 4 区)

(6) Lian Z, Li Y, Xian H, Ouyang XK, Lu Y, Peng X, Hu D. EDTA-functionalized magnetic chitosan oligosaccharide and carboxymethyl cellulose nanocomposite: Synthesis, characterization, and Pb(II) adsorption performance. Int J Biol Macromol. 2020 Dec 15;165(Pt A):591-600.(International Journal of Biological Macromolecules, IF=8.2, 1 区)

(7) Hu D, Lian Z, Xian H, Jiang R, Wang N, Weng Y, Peng X, Wang S, Ouyang XK. Adsorption of Pb(II) from aqueous solution by polyacrylic acid grafted magnetic chitosan nanocomposite. Int J Biol Macromol. 2020 Jul 1;154:1537-1547. (International Journal of Biological Macromolecules, IF=8.2,1 区)

(8) Lian Z, Hu Z, Xian H, Jiang R, Huang H, Jiang Y, Zheng Z, Lloyd RS, Yuan J, Sha Y, Wang S, Hu D.Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression. Chemosphere. 2020 Apr;244:125496. (Chemosphere, IF=8.8, 2 区)

(9) Jiang R, Huang H, Lian Z, Hu Z, Lloyd RS, Fang D, Li Y, Xian H, Yuan J, Sha Y, Wang S, Hu D.Exosomal miR-221 derived from hydroquinone-transformed malignant human bronchial epithelial cells is involved in cell viability of recipient cells. J Appl Toxicol. 2020

Feb;40(2):224-233. （Journal of Applied Toxicology, IF=3.3, 4 区)

(10) Hu D, Huang H, Jiang R, Wang N, Xu H, Wang YG, Ouyang XK. Adsorption of diclofenac sodium on bilayer amino-functionalized cellulose nanocrystals/chitosan composite. J Hazard Mater. 2019 May 5;369:483-493. (Journal of Hazardous Materials, IF=13.6, 1 区)

(11) Huang H, Jiang R, Lian Z, Zhang W, Hu Z, Hu D. miR-222/GAS5 is involved in DNA damage and cytotoxic effects induced by temozolomide in T98G cell line. J Appl Toxicol. 2019 May;39(5):726-734. (Journal of Applied Toxicology, IF=3.3, 4 区)

(12) Yang J, Wei Q, Peng X, Peng X, Yuan J, Hu D. Relationship between Methyl Tertiary Butyl Ether Exposure and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Petrol Station Attendants in Southern China. Int J Environ Res Public Health. 2016 Sep 23;13(10):946.(International Journal of Environmental Research and Public Health, IF=4.614, 3 区)

(13) Hu D, Peng X, Liu Y, Zhang W, Peng X, Tang H, Yuan J, Zhu Z, Yang J. Overexpression of miR-221 in peripheral blood lymphocytes in petrol station attendants: A population based cross-sectional study in southern China. Chemosphere. 2016 Apr;149:8-13. (Chemosphere, IF=8.8,2 区)

(14) Hu D, Yang J, Liu Y, Zhang W, Peng X, Wei Q, Yuan J, Zhu Z. Health Risk Assessment for Inhalation Exposure to Methyl Tertiary Butyl Ether at Petrol Stations in Southern China. Int J Environ Res Public Health. 2016 Feb 6;13(2):204. (International Journal of Environmental Research and Public Health, IF=4.614, 3 区)

(15) Zhang W, Hu D, Ji W, Yang L, Yang J, Yuan J, Xuan A, Zou F, Zhuang Z. Histone modifications contribute to cellular replicative and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts. Free Radic Res. 2014 May;48(5):550-9. (Free Radical Research,IF=3.3, 3 区)

(16) Ji W, Yang L, Yu L, Yuan J, Hu D, Zhang W, Yang J, Pang Y, Li W, Lu J, Fu J, Chen J, Lin Z, Chen W,Zhuang Z. Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells. Carcinogenesis. 2008 Jun;29(6):1267-75. (Carcinogenesis, IF=4.7, 3 区)

(17) Hu DL, Tang HW, Liang HR, Tang DS, Liu YM, Ji WD, Yuan JH, He Y, Zhu ZY, Yang JP, Fang DK,Sha Y, Tu XZ, Zhuang ZX. Possible role of DNA polymerase beta in protecting human bronchial epithelial cells against cytotoxicity of hydroquinone. Biomed Environ Sci. 2007 Apr;20(2):171-7.PMID: 17624194. (Biomedical and Environmental Sciences, IF=3.5, 3 区)

参编研究生教材：《靶器官毒理学》，化学工业出版社。

1．“几种重要DNA 损伤修复基因及其多态性研究”获广东省人民政府颁发的“广东省科学技术奖”二等奖。

2．“佛山陶瓷企业石英粉尘的人群潜在性损伤及其流行病学干预研究”获佛山市人民政府颁发的“佛山市科学技术奖”三等奖。

3．“几种重要DNA 损伤修复基因及其多态性研究”获深圳市人民政府颁发的“深圳市科技创新奖”。

4．“佛山东平河饮用水源及自来水微囊藻毒素污染动态及对策”获佛山市人民政府颁发的“佛山市科学技术奖”三等奖。

5.广东省“千百十工程”第四批校级重点培养对象。