学术任职
中国毒理学会毒性病理学专委会委员兼副秘书长
中国毒理学会青年委员会委员
中国毒理学会毒理学教育专委会青年委员
广东省环境诱变剂学会理事
科研项目
1) 国家自然科学基金青年项目:肠道上皮细胞Nrf2缺失通过支原体介导IL-17C加剧纳米塑料颗粒致神经毒性的“菌-肠-脑轴”机制研究(82304177),2024.01-2026.12,30万,主持人,在研。
2) 中国博士后基金面上项目:肠道上皮细胞Nrf2缺失通过“菌-肠-脑轴”调控IL-17C加剧纳米塑料颗粒致神经毒性的机制研究(2022M721486),2023.01-2024.12,8万,主持人,已结题。
3) 广东省基础与应用基础研究基金-粤莞联合基金青年项目:Nrf2调控氧化应激抑制纳米塑料颗粒致小肠上皮细胞铁死亡的机制研究(2022A1515111098),2022.10-2025.09,10万,主持人,已结题。
4) 东莞市社会发展科技项目高水平医院建设专项:纳米塑料颗粒通过氧化应激导致小肠上皮细胞铁死亡的机制研究(20231800905372),2023.01-2025.12,20万,主持人,在研。
代表性论文
1) Liang B#, Deng Y#, Huang Y#, Zhong Y#, Li Z, Du J, Ye R, Feng Y, Bai R, Fan B, Chen X, Huang X, Yang X, Xian H, Yang X, Huang Z*. Fragile guts make fragile brains: Intestinal epithelial Nrf2 deficiency exacerbates neurotoxicity induced by polystyrene nanoplastics. ACS Nano, 2024, 18(35):24044-59.(中科院小类一区Top期刊, IF=16.0)
2) Liang B#, Deng Y#, Zhong Y#, Chen X, Huang Y, Li Z, Huang X, Yang X, Du J, Ye R, Xian H, Feng Y, Bai R, Fan B, Yang X, and Huang Z*. Gastrointestinal Incomplete Degradation Exacerbates Neurotoxic Effects of PLA Microplastics via Oligomer Nanoplastics Formation. Advanced Science, 2024, 11(28): e2401009. (中科院小类一区Top期刊, IF=14.3, 封面文章)
3) Liang B#, Huang Y#, Zhong Y#, Li Z, Ye R, Wang B, Zhang B, Meng H, Lin X, Du J, Hu M, Wu Q, Sui H, Yang X*, Huang Z*. Brain single-nucleus transcriptomics highlights polystyrene nanoplastics potentially induce Parkinson’s disease-like neurodegeneration by causing energy metabolism disorders in mice. Journal of Hazardous Materials, 2022, 430: 128459. (中科院小类一区Top期刊, IF=13.6, ESI高被引文章)
4) Liang B#, Huang X#, Li Z#, Huang Y#, Deng Y, Chen X, Zhong Y, Yang X, Feng Y, Bai R, Fan B, Xian H, Li H, Tang S, Huang Z*. Polystyrene nanoplastics trigger ferroptosis in Nrf2 deficiency gut via ether phospholipid accumulation. Environment International, 2025, 197:109367. (中科院小类一区Top期刊, IF=9.7)
5) Liang B#, Zhong Y#, Huang Y#, Lin X#, Liu J, Lin L, Hu M, Jiang J, Dai M, Wang B, Zhang B, Meng H, Lelaka J, Sui H, Yang X*, Huang Z*. Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis. Particle and Fibre Toxicology, 2021,18(1):20. (中科院小类一区Top期刊, IF=10.0, ESI高被引文章)
6) Wang B#, Liang B#, Huang Y#, Li Z#, Zhang B, Du J, Ye R, Xian H, Deng Y, Xiu J, Yang X, Ichihara S, Ichihara G, Zhong Y*, Huang Z*. Long-chain acyl carnitines aggravate polystyrene nanoplastics-induced atherosclerosis by upregulating MARCO. Advanced Science, 2023,10(19): e2205876. (中科院小类一区Top期刊, IF=14.3, 封面文章)
7) Zhang X#, Liang B#, Huang Y#, Meng H, Li Z, Du J, Zhou L, Zhong Y, Wang B, Lin X, Yu G, Chen X, Lu W, Chen Z, Yang X, and Huang Z*. Behind the indolent facade: Uncovering the molecular features and malignancy potential in lung minimally invasive adenocarcinoma by single-cell transcriptomics. Advanced Science, 2023,10(36): e2303753. (中科院小类一区Top期刊, IF=14.3)
8) Deng Y, Li Z, Huang Y, Zhong Y, Qiu A, Chen X, Huang X, Yang X, Feng Y, Bai R, Fan B, Xian H, Li H, Chen D, Liang B*, Huang Z*. Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism. Journal of Advanced Research, 2025, S2090-1232(25)00661-7. (中科院小类一区Top期刊, IF=13.0)
9) Huang Y#, Liang B#, Chen X#, Li Z#, Deng Y, Du J, Zhong Y, Lin X, Fu J, Xie J, Zhang X, Huang Z. Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics. Cell Communication and Signaling, 2025, 23(324). (中科院小类二区Top期刊, IF=8.9)
10) Liang B#, Chen Y#, Yuan W#, Qin F, Zhang Q, Deng N, Liu X, Ma X, Zhang X, Zhang B, Deng Q, Huang M, Tang H, Liu L, Chen W, Xiao Y. Down-regulation of miRNA-451a and miRNA-486-5p involved in benzene-induced inhibition on erythroid cell differentiation in vitro and in vivo, Archives of Toxicology, 2018, 92(1):259-272. (中科院小类一区, IF=6.9)
成果奖励
广州市“青年科技人才托举工程”项目(2025)
教材著作
副主译,《饮用水中的微塑料》,中国标准出版社,2022
副主译,《纳米塑料和微塑料的膳食和吸入暴露及其对人类健康的潜在影响》,中国标准出版社,2024