科研项目
1. 青年科学基金项目（C类）：纳米塑料通过上调星形胶质细胞黄嘌呤激活少突胶质细胞腺苷A1受体加剧老龄小鼠帕金森病样神经损伤的机制研究（8250120019），2026.01-2028.12，30万，主持人，在研。
2. 广东省自然科学基金-面上项目：星形胶质细胞-多巴胺能神经元相互作用在纳米塑料暴露促进老龄小鼠帕金森病进展的作用机制研究（2025A1515011141），2025.01-2027.12，10万，主持人，在研。
代表性论文
（1）Yuji Huang, Boxuan Liang, Zhiming Li, Yizhou Zhong, Bo Wang, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Weicui Min, Xiliang Yan, Yanhong Deng, Yu Feng, Ruobing Bai, Bingchi Fan, Xingfen Yang, Zhenlie Huang*. Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo. Particle and Fibre Toxicology, 2023 Nov 22;20(1):44. (第一作者，中科院毒理学一区，2024年IF=8.2)
（2）Boxuan Liang#, Yuji Huang#, Yizhou Zhong#, Zhiming Li, Rongyi Ye, Bo Wang, Bingli Zhang, Hao Meng, Xi Lin, Jiaxin Du, Manjiang Hu, Qinghong Wu, Haixia Sui, Xingfen Yang*, Zhenlie Huang*. Brain single-nucleus transcriptomics highlights polystyrene nanoplastics potentially induce Parkinson’s disease-like neurodegeneration by causing energy metabolism disorders in mice. Journal of Hazardous Materials, 2022 May 15, 430: 128459. (并列第一作者，2/3，中科院环境科学一区Top期刊，2024年IF=11.3，ESI高被引论文)
（3）Yuji Huang#, Boxuan Liang#, Xuewei Chen# , Zhiming Li, Yanhong Deng , Jiaxin Du, Yizhou Zhong, Xi Lin, Junjun Fu, Jieyu Xie, Xin Zhang*, Zhenlie Huang*. Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics. Cell Commun Signal. 2025 Jul 4;23(1):324. (并列第一作者，1/3，中科院细胞生物学二区，2024年IF=8.9)
（4）Hongrui Feng#, Yuji Huang#, Hanbin Zhang#, Zhiming Li, Xixian Cen, Yuge Zhuang, Xiaoyuan Zhang, Ke Ma, Shipeng Ruan, Runduan Yi, Zicong Huang, Wenyuan Liu, Maoyong Song, Zhenlie Huang*, Zhenguo Chen*. Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice. Particle and fibre toxicology, 2025 Oct 23;22(1):27. (并列第一作者，2/3，中科院毒理学一区，2024年IF=8.2)
（5）Boxuan Liang#, Yanhong Deng#, Yuji Huang#, Yizhou Zhong#, Zhiming Li, Jiaxin Du, Rongyi Ye, Yu Feng, Ruobing Bai, Bingchi Fan, Xiaoqing Chen, Xiyun Huang, Xiaohong Yang, Hongyi Xian, Xingfen Yang, Zhenlie Huang*. Fragile Guts Make Fragile Brains: Intestinal Epithelial Nrf2 Deficiency Exacerbates Neurotoxicity Induced by Polystyrene Nanoplastics. ACS Nano, 2024 Sep 3; 18(35), 24044–24059. (并列第一作者，3/4，中科院纳米科技一区Top期刊，2023年IF=15.8)
（6）Bo Wang#, Boxuan Liang#, Yuji Huang#, Zhiming Li#, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Yanhong Deng, Jiancheng Xiu, Xingfen Yang, Sahoko Ichihara, Gaku Ichihara, Yizhou Zhong*, Zhenlie Huang*. Long-chain acyl carnitines aggravate polystyrene nanoplastics-induced atherosclerosis by upregulating MARCO. Advanced Science, 2023 Jul;10(19):e2205876. (并列第一作者，3/4，中科院材料科学一区Top期刊，2024年IF=14.1)
（7）Boxuan Liang#, Yizhou Zhong#, Yuji Huang#, Xi Lin#, Jun Liu, Li Lin, Manjiang Hu, Junying Jiang, Mingzhu Dai, Bo Wang, Bingli Zhang, Hao Meng, Jesse Justin J. Lelaka, Haixia Sui, Xingfen Yang*, Zhenlie Huang*. Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis. Particle and Fibre Toxicology, 2021 Jun 7;18(1):20. (并列第一作者，3/4，中科院毒理学一区，2024年IF=8.2，ESI高被引论文)
（8）Xin Zhang#, Boxuan Liang#, Yuji Huang#, Hao Meng, Zhiming Li, Jiaxin Du, Lang Zhou, Yizhou Zhong, Bo Wang, Xi Lin, Guangchuang Yu, Xuewei Chen, Weixiang Lu, Zhe-Sheng Chen, Xingfen Yang, Zhenlie Huang*. Behind the indolent facade: Uncovering the molecular features and malignancy potential in lung minimally invasive adenocarcinoma by single-cell transcriptomics. Advanced Science, 2023 Dec;10(36):e2303753. (并列第一作者，3/3，中科院材料科学一区Top期刊，2024年IF=14.1)
（9）Boxuan Liang#, Xiyun Huang#, Zhiming Li#, Yuji Huang#, Yanhong Deng, Xiaoqing Chen, Yizhou Zhong, Xiaohong Yang, Yu Feng, Ruobing Bai, Bingchi Fan, Hongyi Xian, Hao Li, Shiyue Tang, Zhenlie Huang, Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation, Environment International, 2025, 109367. (并列第一作者，4/4，中科院环境科学一区Top期刊，2024年IF=9.7)
（10）黄煜基#,许凯琳#,梁博萱,等.微纳塑料暴露对陆生哺乳动物的神经毒性及其机制[J].化学进展, 2025,37(01):76-88. (并列第一作者，1/2，北大核心期刊)
