教育经历

2004-2008年，香港科技大学，博士学位

工作经历

2011.9- 现在 南方医科大学， 教授、博士生导师

2008.4-2011.9 香港科技大学， 博士后副研究员、研究助理教授

2003.7-2004.8 香港科技大学， 助理研究员

2000.7-2003.6 中国科学院院微生物所， 助理研究员

研究概述

精神疾病（精神分裂症、双相情感障碍和抑郁症等）复杂表型变异的表观遗传调控机制。以双胞胎家系临床病例及其外周血来源构建iPSCs分化的神经元和类脑器官、模式小鼠为对象并结合基因编辑技术，研究等位基因特异性DNA甲基化修饰和RNA表达、非编码RNA等参与精神病复杂表型变异的表观遗传调控机制。

代表性文章

1. Ye, J., Z. Huang, Q. Li, Z. Li, Y. Lan, Z. Wang, C. Ni, X. Wu, T. Jiang, Y. Li, Q. Yang, J. Lim, C. Ren, M. Jiang, S. Li, P. Jin, J. Chen* and C. Zhao*. Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. BMC Medicine, 2023 (PMID: 38082312)

2. Liang, W., Y. Hou, W. Huang, Y. Wang, T. Jiang, X. Huang, Z. Wang, F. Wu, J. Zheng, J. Zhang, H. Ou, S. Li, J. Ping, Y. Zhang, J. Ye, Z. Li, Q. Yang, J. Zhang, X. Zheng, S. Li, X. Zhu, R. Chen* and C. Zhao*. Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission. Science Advances, 2022. 8(33): eabn7357 (PMID:35984881).

3. Li, Q., Z. Wang, L. Zong, L. Ye, J. Ye, H. Ou, T. Jiang, B. Guo, Q. Yang, W. Liang, J. Zhang, Y. Long, X. Zheng, Y. Hou, F. Wu, L. Zhou, S. Li, X. Huang, and C. Zhao*, Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function. Mol Psychiatry, 2021.26(11): p.6630-6642 (PMID: 33963283).

4. Ni, C., W. Jiang, Z. Wang, Z. Wang, J. Zhang, X. Zheng, Z. Liu, H. Ou, T. Jiang, W. Liang, F. Wu, Q. Li, Y. Hou, Q. Yang, B. Guo, S. Liu, S. Li, S. Li, E. Yang, X.H. Zhu, X. Huang, Z. Wen, and C. Zhao*, LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia. Mol Psychiatry, 2021. 26(8): p.4511-4528 (PMID: 32015466).

5. Bao, X., X. Zhang, L. Wang, Z. Wang, J. Huang, Q. Zhang, Y. Ye, Y. Liu, D. Chen, Y. Zuo, Q. Liu, P. Xu, B. Huang, J. Fang, J. Lao, X. Feng, Y. Li, R. Kurita, Y. Nakamura, W. Yu, C. Ju, C. Huang, N. Mohandas, D. Li, C. Zhao*, and X. Xu*, Epigenetic inactivation of ERF reactivates gamma-globin expression in beta-thalassemia. Am J Hum Genet, 2021. 108(4): p. 709-721 (PMID:33735615).

6. Chen, D., Y. Zuo, X. Zhang, Y. Ye, X. Bao, H. Huang, W. Tepakhan, L. Wang, J. Ju, G. Chen, M. Zheng, D. Liu, S. Huang, L. Zong, C. Li, Y. Chen, C. Zheng, L. Shi, Q. Zhao, Q. Wu, S. Fucharoen, C. Zhao*, and X. Xu*, A Genetic Variant Ameliorates beta-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. Am J Hum Genet, 2017. 101(1): p. 130-138 (PMID:28669403).

7. Jiang, T., L. Zong, L. Zhou, Y. Hou, L. Zhang, X. Zheng, H. Han, S. Li, W. Zhang, J. Zhang, C. Deng, Y. Jia, and C. Zhao*, Variation in global DNA hydroxymethylation with age associated with schizophrenia. Psychiatry Res, 2017.257: p. 497-500 (PMID:28841512).

8. Wu, X., J. Ye, Z. Wang, and C. Zhao*, Epigenetic age acceleration was delayed in schizophrenia. Schizophrenia Bulletin, 2021. 47(3): p.803-811 (PMID: 33269797).