教育经历

2013.12 - 2019.10，香港城市大学，博士

2005.09 - 2010.06，南方医科大学，学士

工作经历

2025.12 – 至今,   南方医科大学，教授

2024.08 – 2025.11, 南加州大学，  Research Associate

2021.08 – 2024.08, 南加州大学，  博士后

2019.10 – 2021.07, 香港城市大学，博士后

研究概述

本课题组致力于阐明社会行为的神经机制，重点聚焦亲社会行为的神经环路基础及其调控规律。我们结合行为学、神经环路操控与多尺度神经活动记录等手段，解析社会互动中关键脑区与通路如何协同工作，并进一步探究自闭症、抑郁症及反社会型人格障碍等疾病中社会行为异常的病理机制，探索具有转化潜力的干预策略与潜在治疗靶点。承担国家级青年人才项目。

代表性文章

1. Sun, W.^#, Zhang, G-W. ^#, Huang, JJ., Tao, C., Seo, MB., Tao, HW.*, Zhang, LI.*. Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents. Science. 2025 Feb 21;387(6736):eadq2677. doi:10.1126/science.adq2677 (IF, 44.8)

2. Tao C, Zhang GW, Sun W, Huang JJ, Zhang LI, Tao HW. Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states. Nat Commun. 2024 Oct 3;15(1):8575. doi: 10.1038/s41467-024-52727-2. (IF, 16.6)

3. Sun, W. ^#, Wu, H.^#, Peng, Y.^#, Zheng, X. ^#, Li,J. ^#, Zeng, D. ^#, Tang, P., Zhao, M., Feng, H., Li, H., Liang, Y., Su, J., Chen, X.*, Hökfelt, T. *, He, J*. (2024) Heterosynaptic plasticity of the visuo-auditory projection requires cholecystokinin released from entorhinal cortex afferents. eLife 13:e83356. https://doi.org/10.7554/eLife.83356 (IF, 7.7)

4. Zhang N, Sui Y, Jendrichovsky P, Feng H, Shi H, Zhang X, Xu S, Sun W, Zhang H, Chen X, Tortorella MD, He J. Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice. Alzheimers Res Ther. 2024 May 15;16(1):109. doi: 10.1186/s13195-024-01472-1. (IF, 9)

5. He L, Shi H, Zhang G, Peng Y, Ghosh A, Zhang M, Hu X, Liu C, Shao Y, Wang S, Chen L, Sun W, Su J, Chen X, Zhang L, Chan YS, Pei D, Tortorella M, Guo Y, Yan H, He J. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition. J Neurosci. 2023 Mar 29;43(13):2305-2325. doi: 10.1523/JNEUROSCI.2035-22.2023. (IF, 6.709)

6. Sun, W. ^#, Tang, P. ^#, Liang, Y. ^#, Li, J., Feng, J., Zhang, N., Lu, D., He, J.* and Chen, X.* (2022). The anterior cingulate cortex directly enhances auditory cortical responses in air-puffing-facilitated flight behavior. Cell Reports, 38(10), 110506. https://doi.org/10.1016/j.celrep.2022.110506 (IF, 9.423)

7. Zhang, Z.^#, Zheng, X.^#, Sun, W. ^#, Peng, Y., Guo, Y., Lu, D., Zheng, Y., Li, X., Jendrichovsky, P., Tang, P., He, L., Li, M., Liu, Q., Xu, L., Ng, G., Chen, X., He, J*. Visuoauditory associative memory established with cholecystokinin under anesthesia is retrieved in behavioral contexts. J Neurosci. 2020 Mar 4;40(10):2025-2037. doi: 10.1523/JNEUROSCI.1673-19.2019. (IF, 6.074)

8. Wang, H., Chen, J., Xu, X., Sun, W., Chen, X., Zhao, F., ... & Zhong, H. (2019). Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior. PLOS Biology, 17(8), e3000417. https://doi.org/10.1371/journal.pbio.3000417 (IF, 8.386)

9. Chen, X., Li, X., Wong, Y. T., Zheng, X., Wang, H., Peng, Y., Feng, H., Feng, J., Baibado, J.T., Jesky. R., Wang, Z., Xie, H., Sun, W., ... & Wang, Z. (2019). Cholecystokinin release triggered by NMDA receptors produces LTP and sound–sound associative memory. Proceedings of the National Academy of Sciences, 116(13), 6397-6406. http://doi.org/10.1073/pnas.1816833116 (IF, 9.504).

10. Zhang, G.-W.^#, Sun, W.^#, Zingg, B., Shen, L., He, J., Xiong, Y.*, Tao, H.W.*, Zhang, L. I.* (2018). A Non-canonical Reticular-Limbic Central Auditory Pathway via Medial Septum Contributes to Fear Conditioning. Neuron, 97(2), 406–417.e4. https://doi.org/10.1016/j.neuron.2017.12.010 (IF, 14.024)

11. Li, X., Yu, K., Zhang, Z., Sun, W., Yang, Z., Feng, J., Chen, X., Liu, C., Wang, H., Guo, Y., He, J. (2014). Cholecystokinin from the entorhinal cortex enables neural plasticity in the auditory cortex. Cell Research, 24(3), 1–24. https://doi.org/10.1038/cr.2013.164

(^#共同第一作者; *通讯作者; IF为论文发表当年影响因子)

招生计划

课题组长期招收硕士、博士研究生、博士后及研究助理等，欢迎对神经科学有兴趣的青年科研人员加入。