教育经历

2018年-2022年，中山大学，博士

工作经历

2025年-至今，南方医科大学，教授

2022年-2025年，中山大学中山医学院，博士后

研究概述

在社会互动中，情绪是调控个体行为的重要内在状态。然而，在具体社会情境中，大脑如何整合个体的情绪状态与外界社会线索，并将其转化为恰当的行为反应，其神经机制仍不清楚。阐明情绪与社会信息整合的神经基础，对于理解社会行为的基本生物学规律具有重要意义。

基于上述科学问题，本课题组聚焦情绪与社会行为相互作用的神经机制，重点研究个体如何感知、解读并响应社会线索，以及大脑如何通过动态调节情绪状态来塑造社会行为。我们的研究方向主要包括：1）情绪-社会行为整合的神经环路机制；2）焦虑障碍、自闭症谱系障碍、抑郁症等精神疾病中情绪调控与社会行为异常的神经基础及潜在干预靶点。相关研究成果已发表在Neuron、Current Biology、Neuroscience、Acta Pharmacologica Sinica等国际学术期刊。

代表性文章

1. Shunchang Fang, Zhengyi Luo, Zicheng Wei, Yuxin Qin, Jieyan Zheng, Hongyang Zhang, Jianhua Jin, Jiali Li, Chenjian Miao, Shana Yang, Yonglin Li, Zirui Liang, Xiao-Dan Yu, Xiao Min Zhang, Wei Xiong, Hongying Zhu, Wen-Biao Gan, Lianyan Huang*, Boxing Li*. Sexually dimorphic control of affective state processing and empathic behaviors. Neuron. 2024; 112(9):1498-1517.e8.

2. Shunchang Fang#, Yuxin Qin#, Hanbing Lian#, Yufang Zhong, Yishuai Yang, Xiao-Dan Yu, Shana Yang, Jiankai Liang, Wenhui Xiao, Songhai Wen, Xiao Min Zhang, Boxing Li*, Lianyan Huang*. Reduced oxytocin signaling in the dBNST drives the transition from acute pain to persistent anxiety. Current Biology. 2025; 35(21):5150-5166.e8.

3. Shunchang Fang#, Yuxin Qin#, Shana Yang, Hongyang Zhang, Jieyan Zheng, Songhai Wen, Weimin Li, Zirui Liang, Xiaomin Zhang, Boxing Li*, Lianyan Huang*. Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors. Frontiers in Molecular Neuroscience. 2023; 16:1185243.

4. Shunchang Fang, Hang Xie, Fang Chen, Mei Hu, Yan Long, Hong-Bin Sun, Ling-Yi Kong, Hao Hong*, Su-Su Tang*. Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice. Neuroscience. 2017; 355:200-211.

5. Jing-Ran Lin#, Shunchang Fang#, Su-Su Tang, Mei Hu, Yan Long, Arijit Ghosh, Hong-Bin Sun, Ling-Yi Kong, Hao Hong*. Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice. Acta Pharmacologica Sinica. 2017; 38(4):477-487.

6. Lixi Chen#, Zhiduo Zhang#, Shana Yang#, Yun Tang, Xuanhe Wang, Wenfu Li, Lin Yang, Chenyi Guo, Shunchang Fang, Wenhui Xiao, Minbiao Yan, Yonglin Li, Taixuan Peng, Boxing Li, Xiao Min Zhang*, Lianyan Huang*. Developmental neuroplasticity enables recovery from anesthetic-induced synaptic perturbations in the immature brain. Neurochemistry International. 2025; 190:106051.

7. Jieyan Zheng#, Xiao Min Zhang#, Wenting Tang, Yonglin Li, Pei Wang, Jianhua Jin, Zhengyi Luo, Shunchang Fang, Shana Yang, Zicheng Wei, Kexin Song, Zihan Huang, Zihao Wang, Ziyu Zhu, Naizhen Shi, Diyun Xiao, Linyu Yuan, Hualin Shen, Lianyan Huang*, Boxing Li*. An insular cortical circuit required for itch sensation and aversion. Current Biology. 2024; 34(7):1453-1468.e6.

8. Shana Yang#, Song Zhang#, Wenting Tang#, Shunchang Fang, Hongyang Zhang, Jieyan Zheng, Xia Liu, Ying Zhang, Liang Zhao, Lianyan Huang*, Boxing Li*. Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction. Frontiers in Aging Neuroscience. 2021; 13:744719.

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