Education

2015.09—2020.07，Institute of Biophysics, Chinese Academy of Sciences, Ph.D

2011.09—2015.07，Minzu University of China, BS

Employment

2023.02—Now，Southern University of China，Professor/Principal Investigator

2020.07—2023.01，Beijing Institute of Basic Medical Sciences，Post doctor fellow

Research Overview

Dr. Pan received his Ph.D. degree in Neuroscience at Institute of Biophysics, Chinese Academy of Sciences, Beijing, China in 2020. Then, he was training as a postdoctoral researcher in the Brain Science Center, Beijing Institute of Basic Medical Sciences. Dr. Pan joined in the Great Bay Area Center for Brain Research as a Principal Investigator in 2023. His lab focuses on the pathogenesis of Alzheimer’s disease, the crosstalk between glial metabolism and neuroinflammation, and the functions of gut-brain axis in neurological disorders.

Selective Publications

(^#co-first author; *Corresponding author)

1. Rui-Yuan Pan^#; Lin He^#; Jing Zhang; Xinhua Liu; Yajin Liao; Ju Gao; Yang Liao; Yuhan Yan; Qianqian Li; Xuehong Zhou; Jinbo Cheng; Qu Xing; Fangxia Guan; Jie Zhang; Luyang Sun*; Zengqiang Yuan*; Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease, Cell Metabolism, 2022, 34(4): 634-648.e6 (Highlighted by Nature Chemical Biology and Molecular Neurodegeneration)

2. Rui-Yuan Pan^#*; Jing Zhang^#; Jinlei Wang; Yingyi Wang; Zhihui Li; Yang Liao; Yajin Liao; Chenggang Zhang; Zhiqiang Liu; Lijuan Song; Jiezhong Yu; Zengqiang Yuan*; Intermittent fasting protects against Alzheimer’s disease in mice by altering metabolism through remodeling of the gut microbiota, Nature Aging, 2022, 2(11): 1024-1039 (Commented by Yvonne M. Nolan in Nature Aging)

3. Qianqian Li; Caixia Jia; Hongxing Wu; Yajin Liao; Ke Yang; Shuoshuo Li; Jing Zhang; Jinlei Wang; Guo Li; Fangxia Guan; Elaine Leung; Zengqiang Yuan*; Qian Hua*; Rui-Yuan Pan*; Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation, Pharmacological Research, 2022, 185: 106489-106489

4. Lige Leng; Ziqi Yuan; Ruiyuan Pan; Xiao Su; Han Wang; Jin Xue; Kai Zhuang; Ju Gao; Zhenlei Chen; Hui Lin; Wenting Xie; Huifang Li; Zhenyi Chen; Keke Ren; Xiao Zhang; Wenting Wang; Zi-Bing Jin; Shengxi Wu; Xinglong Wang; Zengqiang Yuan; Huaxi Xu; Hei-Man Chow; Jie Zhang ; Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance, Nature Metabolism, 2022, 4(10): 1287-1305

5. Rui-Yuan Pan^#; Xiang-xi Kong^#; Yong Cheng; Lu Du; Zhen-chao Wang; Chao Yuan; Jin-bo Cheng; Zeng-qiang Yuan; Hai-yan Zhang*; Ya-jin Liao*; 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis, Acta Pharmacologica Sinica, 2021, 42(11): 1769-1779 (Cover story)

6. Yang Liao; Qu Xing; Qianqian Li; Jing Zhang; Rui-Yuan Pan*; Zengqiang Yuan*; Astrocytes in depression and Alzheimer’s disease, Frontiers of Medicine, 2021, 2021(15): 0-829–841  

7. Shuoshuo Li; Jun Li; Rui-Yuan Pan; Jinbo Cheng; Qinghua Cui; Jianxin Chen; Zengqiang Yuan; Sodium rutin extends lifespan and health span in mice including positive impacts on liver health., British journal of pharmacology, 2021, 2021: 1-14

8. Jinbo Cheng; Yuan Dong; Jun Ma; Rui-Yuan Pan; Yajin Liao; Xiangxi Kong; Xiaoheng Li; Shuoshuo Li; Pingfang Chen; Liang Wang; Ye Yu; Zengqiang Yuan; Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology., Science Advances, 2021, 7(35): 0-eabe3600

9. Rumeng Yao; Ruiyuan Pan; Chao Shang; Xiaoheng Li; Jinbo Cheng; Jiangping Xu; Yunfeng Li; Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function, Frontiers in Pharmacology, 2020, 11: 0-986

10. Rui-Yuan Pan; Jun Ma; Xiang-Xi Kong; Xiao-Feng Wang; Shuo-Shuo Li; Xiao-Long Qi; Yu-Han Yan; Jinbo Cheng; Qingsong Liu; Wanzhu Jin; Chang-Heng Tan; Zengqiang Yuan*; Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance, Science Advances, 2019, 5(2): 15

11. Jun Ma^#; Xiaolong Qi^#; Chaojuan Yang; Rui-Yuan Pan; Shukun Wang; Junbing Wu; Li Huang; Hong Chen; Jinbo Cheng; Rong Wu; Yajin Liao; Lanqun Mao; Fengchao Wang; Zhiying Wu; Jianxiong An; Yun Wang; Xia Zhang; Chen Zhang; Zengqiang Yuan; Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors, Molecular Psychiatry, 2018, 23(4): 883-891.

12. Rui-Yuan Pan; Jun Ma; Huan-Tong Wu; Qing-Shan Liu; Xiao-Yan Qin; Yong Cheng; Neuroprotective effects of a Coeloglossum viride var. Bracteatum extract in vitro and in vivo, Scientific Reports, 2017, 7(1): 0-9209