Education

2004-2008 Southern Medical University  Medical Examination  Bachelor

2008-2014 Southern Medical University  Neurobiology   PhD

Experience

2014 -2017，Medical College of Georgia in USA ，postdoctor

2017 -2023，Guangzhou Medical University，professor

2023-present，Southern Medical University，professor

Research Interest

Prolonged and excessive stress is an important factor leading to mood disorders.

My lab is committed to the study of its pathological mechanisms and intervention strategies. The main academic achievements include: (1) finding that abnormal glycolytic-lactic acid signaling is the important cause of depression induced by chronic social defeat stress, which provides a new mechanism for the pathogenesis of depression; (2) dissecting the molecular mechanism regulating the release of anti-depressant molecule ATP in the brain, and proposed the non-drug intervention mode of depression - ketogenic diet, which provides new targets and new ideas for the development of anti-depressant drugs and the development of prevention and treatment strategies; (3) revealing the circuit and molecular mechanisms underlying fear and anxiety induced by pain stress, providing new clues for the clinical prevention and treatment of chronic pain accompanied by anxiety disorders. The applicant, as the correspondence or first author, has published many papers in Nat Neurosci, Neuron, Nat Commun, J Clin Invest, J Neurosci, and other well-known journals, which have been cited and commented on by peer experts many times. In addition, the applicant has received two grants from National Natural Science Foundation, an “Outstanding Youth” grant from Guangdong Natural Science Foundation and won the first prize of the Guangdong Natural Science Awardand the title of "Young Pearl River Scholar".

Publications

1. Yao S^#, Xu MD^#, Wang Y^#, Zhao ST^#, Wang J, Chen GF, Chen WB, Liu J, Huang GB, Sun WJ, Zhang YY, Hou HL, Li L, Sun XD* (2023) Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice. Nature Communications 2023 14(1):729.

2. Gao F^#, Huang J^#, Huang GB^#, You QL^#, Yao S, Zhao ST, Liu J, Wu CH, Chen GF, Liu SM, Yu ZY, Zhou YL, Ning YP, Liu SQ, Hu BJ, Sun XD* (2023) Elevated prelimibic-cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain. Journal of Clincial Investigation 2023, in press.

3. Sun XD^#*, Li L^#, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, & Mei L (2016) Lrp4 in astrocytes modulates glutamatergic transmission. Nature neuroscience 19(8):1010-1018.

4. Guan YF^#, Huang GB^#, Xu MD^#, Gao F^#, Lin S^#, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan AG*, Sun XD* (2020) Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula. Brain Behavvior and Immunity 88:748-762.

5. Sun XD^#*, Chen WB^#, Sun D^#, Huang J, Li YQ, Pan JX, Wang YN, Zhao K, Dong ZQ, Wang HS, Xiong L, Xuan A, Zhao ST, Pillai A, Xiong WC, & Mei L* (2018) Neogenin in Amygdala for Neuronal Activity and Information Processing. The Journal of neuroscience 38(44):9600-9613.

6. Ren J, Lu CL, Huang J, Fan J, Guo F, Mo JW, Huang WY, Kong PL, Li XW, Sun  LR, Sun XD*, Cao X*. A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors. Journal of neuroscience 42(11):2356-2370.

7. Lu Y^#, Sun XD^#, Hou FQ, Bi LL, Yin DM, Liu F, Chen YJ, Bean JC, Jiao HF, Liu X, Li BM, Xiong WC, Gao TM*, & Mei L* (2014) Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory. Neuron 84(4):835-846.

8. Jiao HF^#, Sun XD^#, Bates R^#, Xiong L, Zhang L, Liu F, Li L, Zhang H-S, Wang S-Q, Xiong M-T, Patel M, Stranahan AM, Xiong W-C, Li B-M*, & Mei L* (2017) Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus. PNAS 114(5):1177-1182.

9. Wang YN^#, Figueiredo D^#, Sun XD^#, Dong ZQ, Chen WB, Cui WP, Liu F, Wang HS, Li HW, Robinson H, Fei EK, Pan BX, Li BM, Xiong WC, & Mei L (2018) Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. PNAS 115(10):2508-2513.