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Gao Tianming


Chang Jiang Scholar: Gao Tianming
Name: Gao Tianming
Type of SupervisorAcademic Supervisor of PhD degree candidates
Research Focus: New Targets and New Methods for Neuroprotection and Antidepression
Academic TitleExecutive director of Chinese Neuroscience Society; Chairman of Synaptic Plasticity Branchin Chinese Neuroscience Society; Director of Chinese Physiological Society.
The Main Research Direction and its Characteristics and Significance, the Development of New Medicine and New Technology, the Domestic Academic Status
Stroke has become China's second largest cause of death and the top cause of disability. Depression after stroke is a major obstacle in stroke rehabilitation. But clinically there is no effective neuroprotective drugs and ideal antidepressants. Gao Tianming has carried out a series of studies on new targets and new tools of neuroprotection and anti-depression, makingan original and systematic contribution to this field. He has been specially invited as Professor of Changjiang Scholarships by the Ministry of Education and has won the honorary title of the National Outstanding Youth.As the first contributor, he has gained second-grade prize of National Natural Science Award. He has published more than 40 papers in prestigious journals indexed in SCI, such as Nat Med (IF=28.05), Nat Neurosci(IF=14.98), Neuron (IF=15.98)and PNAS (IF=9.81), etc., which were cited more than 900 times. Experts speak highly of his research in three-page reviews respectively published in Nature and Neuron. Among doctoral students he supervises, two have won the honorary title of the National Outstanding Youth and one hasgained Award of National Excellent Doctoral Dissertation.
Honorable Titles and Awards:
1、the second-grade prize of National Natural Science Award, 2011 (the 1stcontributor).
2、the first-grade prize of Science and Technology Award in Guangdong Province, 2009 (the 1stcontributor).
3、the second-grade prize of China Medical Science and Technology Award,2009 (the 1st contributor);
4、the second-grade prize of Natural Science Award in the Ministry of Education,2009(the 1st contributor);
5、Appraised as one of One-Hundred Talentsin Guangdong Province, 2013
6、Distinguished Teacher Award in Guangdong Higher Education in 2011;
7、Outstanding Science and Technology Workers in China , 2010;
8、Supervisor of National Excellent Doctoral Dissertation in 2008.
Published Papers1、Astrocyte-derived ATP modulates depressive-like behaviors. Nature Med. 2013 Jun;19(6):773-7. (IF=28.054) , Corresponding author;
2、Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci. 2014 Aug;17(8):1055-63. (IF=14.976), Corresponding author;
3、Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory, Neuron 2014(in press)(IF=15.982), Corresponding author;
4、Neuregulin-1 Enhances Depolarization-induced GABA Release. Neuron 2007 May;54(4):599-610. ( IF=15.982), Corresponding author;
5、ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21818-23.(IF=9.809), Corresponding author;
6、Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors. Neuropsychopharmacol 2014(in press)(IF=7.833), Corresponding author;
7、Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats. J Neurosci. 2010 Sep 22;30(38):12653-63. ( IF=6.747) , Corresponding author;
8、Contribution of Down-Regulation of L-type Calcium Currents to Delayed Neuronal Death in Rat Hippocampus after Global Cerebral Ischemia and Reperfusion. J Neurosci. 2007 May;27(19):5249-59. ( IF=6.747) , Corresponding author;
9、Activation of BKCa Channels Mediates Hippocampal Neuronal Death After Reoxygenation and Reperfusion. Mol Neurobiol. 2013 Dec;48(3):794-807. (IF=5.286), Corresponding author;
10、An L-type calcium channel agonist, Bay K8644, extends the window of intervention against ischemic neuronal injury. Mol Neurobiol. 2013 Feb;47(1):280-9. ( IF= 5.286) , Corresponding author.
Representative Papers

Astrocyte-derived ATP modulates depressive-like behaviors.
Nature Med
Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling.
Nat Neurosci.
Activation of BKCa channels mediates hippocampal neuronal death after reoxygenation and reperfusion..
Mol Neurobiol.

Scientific research grants

经费(万元)Funds( 10000 Yuan)
Schizophrenia susceptibility pathway neuregulin
regulatory role ErbB4 plays in Fear and Anxiety and its Mechanism
National level
Occurrence and Prevention of Depression: Basic and Clinical Perspectives
Municipal level
Regulating role Erbin plays in anxiety and depression-like behaviors and its Mechanism
Provincial level
Regulatory Role Astrocytes play in hippocampal-dependent learning and memory and its Mechanism
National level