姓名：王起
邮箱：wangqi1980@smu.edu.cn; wangqi_legmed@126.com
职称：教授
职务：无
研究方向：法医病理学、法医毒理学、环境法医学
链接：https://loop.frontiersin.org/people/593150/overview
教育经历：2008.04-2012.03 大阪市立大学 博士
2004.09-2007.07 中国医科大学 硕士
1999.09-2004.07 中国医科大学 学士
工作经历：2021.10- 南方医科大学 教授
2013.06-2021.09 南方医科大学 副教授
2012.04-2013.05 大阪市立大学 Assistant professor
2007.10-2008.03 大阪市立大学 Research Assistant
科研项目：国家自然科学基金面上项目，2022.1-2025.12
广东省基础与应用基础研究基金自然科学基金项目，2021.1.1-2023.12.31
广州市科技计划项目，2020.4-2023.3
国家自然科学基金面上项目，2019.1-2022.12
国家自然科学基金青年科学基金项目，2015.1-2017.12
广东省自然科学基金项目，2014.10-2017.10
学术及科研成果、专利、论文：
英文：
1. Zhang KK, Liu JL, Chen LJ, Li JH, Yang JZ, Xu LL, Chen YK, Zhang QY, Li XW, Liu Y, et al: Gut microbiota mediates methamphetamine-induced hepatic inflammation via the impairment of bile acid homeostasis. Food Chem Toxicol 2022:113208.
2. Zhang KK, Chen LJ, Li JH, Liu JL, Wang LB, Xu LL, Yang JZ, Li XW, Xie XL, Wang Q: Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice. Front Microbiol 2022, 13:755189.
3. Xu LL, Chen YK, Zhang QY, Chen LJ, Zhang KK, Li JH, Liu JL, Wang Q, Xie XL: Gestational exposure to GenX induces hepatic alterations by the gut-liver axis in maternal mice: A similar mechanism as PFOA. Sci Total Environ 2022, 820:153281.
4. Wang LB, Xu LL, Chen LJ, Zhang KK, Zhang QY, Chen YK, Li JH, Liu JL, Wang Q, Xie XL: Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice. Toxicol Appl Pharmacol 2022, 443:116011.
5. Wang LB, Chen LJ, Wang Q, Xie XL: Silencing the Tlr4 Gene Alleviates Methamphetamine-Induced Hepatotoxicity by Inhibiting Lipopolysaccharide-Mediated Inflammation in Mice. Int J Mol Sci 2022, 23.
6. Liu JL, Zheng YH, Chen LJ, Zhang KK, Li JH, Yang JZ, Li XW, Zhao D, Xie XL, Wang Q: mRNA microarray analysis for the identification of potential biomarkers for vital reaction in burned skin: a preliminary pilot study. Forensic Sci Med Pathol 2022.
7. Wang H, Liu W, Zhang DY, Si WY, Yang QL, Lu LW, Wang FH, Li L, Wang Q, Xia HM: Surface topography index: a novel deformity severity assessment index for pectus excavatum. Transl Pediatr 2021, 10:2044-2051.
8. Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q: Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice. Food Chem Toxicol 2021, 148:111946.
9. Zhao D , Cao Z , Wang Q . Forensic examination of abusive head trauma in child abuse cases[J]. Journal of Forensic Science and Medicine, 2021, 7(2):47.
10. Zhou WT, Wang LB, Yu H, Zhang KK, Chen LJ, Wang Q, Xie XL: N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses. PeerJ 2020, 8:e9720.
11. Zhao D, Wang Q, Zhou WT, Wang LB, Yu H, Zhang KK, Chen LJ, Xie XL: PCB52 exposure alters the neurotransmission ligand-receptors in male offspring and contributes to sex-specific neurodevelopmental toxicity. Environ Pollut 2020, 264:114715.
12. Zhang K, Cheng M, Xu J, Chen L, Li J, Li Q, Xie X, Wang Q: MiR-711 and miR-183-3p as potential markers for vital reaction of burned skin. Forensic Sciences Research 2020:1-7.
13. Xu L-Y, Lei F-Z, Lin J-X, Song L, Li X-Y, Wang Q: Stature estimation from body dimensions in Han population of Southern China. Journal of Forensic Science and Medicine 2020, 6:126-134.
14. Tan XH, Zhang KK, Xu JT, Qu D, Chen LJ, Li JH, Wang Q, Wang HJ, Xie XL: Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats. Food Chem Toxicol 2020, 137:111179.
15. Qu D, Zhang K, Chen L, Wang Q, Wang H: RNA-sequencing analysis of the effect of luteolin on methamphetamine-induced hepatotoxicity in rats: a preliminary study. PeerJ 2020, 8:e8529.
16. Xue Y, He JT, Zhang KK, Chen LJ, Wang Q, Xie XL: Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway. Biochem Biophys Res Commun 2019, 509:395-401.
17. Xie XL, Zhou WT, Zhang KK, Yuan Y, Qiu EM, Shen YW, Wang Q: PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats. Chemosphere 2019, 227:389-400.
18. Qu D, Tan XH, Zhang KK, Wang Q, Wang HJ: ATF3 mRNA, but not BTG2, as a possible marker for vital reaction of skin contusion. Forensic Sci Int 2019, 303:109937.
19. Huang E, Huang H, Guan T, Liu C, Qu D, Xu Y, Yang J, Yan L, Xiong Y, Liang T, et al: Involvement of C/EBPbeta-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicol Lett 2019, 312:11-21.
20. Ye MY, Xu D, Liu JC, Lyu HP, Xue Y, He JT, Huang HY, Zhang KK, Xie XL, Wang Q: IL-6 and IL-20 as potential markers for vitality of skin contusion. J Forensic Leg Med 2018, 59:8-12.
21. Xu J, Zhao R, Xue Y, Xiao H, Sheng Y, Zhao D, He J, Huang H, Wang Q, Wang H: RNA-seq profiling reveals differentially expressed genes as potential markers for vital reaction in skin contusion: a pilot study. Forensic Sciences Research 2018, 3:153-160.
22. Xie XL, Zhou WT, Zhang KK, Chen LJ, Wang Q: METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum. Front Neurosci 2018, 12:802.
23. Xie XL, He JT, Wang ZT, Xiao HQ, Zhou WT, Du SH, Xue Y, Wang Q: Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum. Toxicol Lett 2018, 289:107-113.
24. Wang Q, Wei LW, Zhou WT, Wang ZT, Xie XL: PCB28 and PCB52 induce hepatotoxicity by impairing the autophagic flux and stimulating cell apoptosis in vitro. Toxicol Lett 2018, 289:28-41.
25. Sun KJ, He JT, Huang HY, Xue Y, Xie XL, Wang Q: Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis. Forensic Sci Med Pathol 2018, 14:209-215.
26. Lyu H-P, Cheng M, Liu J-C, Ye M-Y, Xu D, He J-T, Xie X-L, Wang Q: Differentially expressed microRNAs as potential markers for vital reaction of burned skin. Journal of Forensic Science and Medicine 2018, 4:135-141.
27. He JT, Huang HY, Qu D, Xue Y, Zhang KK, Xie XL, Wang Q: CXCL1 and CXCR2 as potential markers for vital reactions in skin contusions. Forensic Sci Med Pathol 2018, 14:174-179.
28. Wang Q, Wei LW, Xiao HQ, Xue Y, Du SH, Liu YG, Xie XL: Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies. Food Chem Toxicol 2017, 105:61-72.
29. Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du SH, Xue Y, Xie XL, Wang Q: Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. Sci Rep 2017, 7:1691.
30. Du SH, Tan XH, Zhao R, Zhao D, Xue Y, Wang HJ, Xie XL, Wang Q: Molecular pathology of cerebral TNF-alpha, IL-1beta, iNOS and Nrf2 in forensic autopsy cases with special regard to deaths due to environmental hazards and intoxication. Forensic Sci Med Pathol 2017, 13:409-416.
31. Xue Y, Zhao R, Du SH, Zhao D, Li DR, Xu JT, Xie XL, Wang Q: Decreased mRNA levels of cardiac Cx43 and ZO1 in sudden cardiac death related to coronary atherosclerosis: a pilot study. Int J Legal Med 2016, 130:915-922.
32. Du Y, Jin HN, Zhao R, Zhao D, Xue Y, Zhu BL, Guan DW, Xie XL, Wang Q: Molecular Pathology of Pulmonary Edema in Forensic Autopsy Cases with Special Regard to Fatal Methamphetamine Intoxication. J Forensic Sci 2016, 61:1531-1537.
33. Zhao TL, Xue Ye, Tan XH, Qiao DF, Xie XL , Wang Q: Fatal Thigh Compartment Syndrome: A Case Report and Review of Literature. Jacobs Journal of Forensic Science 2015, 1(2):007
34. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication. Int J Legal Med 2014, 128:469-474.
35. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of pulmonary edema in forensic autopsy cases with special regard to fatal hyperthermia and hypothermia. Forensic Sci Int 2013, 228:137-141.
36. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection. Int J Legal Med 2013, 127:881-889.
37. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Stability of endogenous reference genes in postmortem human brains for normalization of quantitative real-time PCR data: comprehensive evaluation using geNorm, NormFinder, and BestKeeper. Int J Legal Med 2012, 126:943-952.
38. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Molecular pathology of pulmonary edema after injury in forensic autopsy cases. Int J Legal Med 2012, 126:875-882.
39. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Quantitative immunohistochemical analysis of human brain basic fibroblast growth factor, glial fibrillary acidic protein and single-stranded DNA expressions following traumatic brain injury. Forensic Sci Int 2012, 221:142-151.
40. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Intrapulmonary aquaporin-5 expression as a possible biomarker for discriminating smothering and choking from sudden cardiac death: a pilot study. Forensic Sci Int 2012, 220:154-157.
41. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H: Evaluation of human brain damage in fatalities due to extreme environmental temperature by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP), S100beta and single-stranded DNA (ssDNA) immunoreactivities. Forensic Sci Int 2012, 219:259-264.
42. Wang Q, Michiue T, Ishikawa T, Zhu BL, Maeda H: Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases. Leg Med (Tokyo) 2011, 13:226-232.
43. Wang Q, Ishikawa T, Michiue T, Zhu BL, Maeda H: Evaluation of human brain damage in fire fatality by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP) and single-stranded DNA (ssDNA) immunoreactivities. Forensic Sci Int 2011, 211:19-26.
44. Wang Q, Ishikawa T, Michiue T, Maeda H: Fatal facial-intracranial impalement injury in an accidental fall from a height: an autopsy case report with a review of the literature. Forensic Sci Int 2010, 200:e21-24.
45. Wang Q, Ishikawa T, Quan L, Zhao D, Li DR, Michiue T, Chen JH, Zhu BL, Maeda H: Immunohistochemical distribution of basic fibroblast growth factor (bFGF) in medicolegal autopsy. Leg Med (Tokyo) 2009, 11 Suppl 1:S161-164..
中文：
1. 林洁璇,陈倩玲, 王起.新冠肺炎疫情下法医学线上实习实践[J].南方医学教育,2021,32(1):41-44.
2. 王寒,高云贵,刘晋岑,赵铁岭,宁波,王起*.ZFP36和Rasd1的mRNA鉴别生前、死后挫伤的意义[J].中国法医学杂志,2020,35(05):486-489.
3. 涂文建,黄庆万,叶明园,魏文浩,王起.关于法医学公安实习基地建设的探讨[J].医学教育研究与实践,2020,28(02):265-268.
4. 王起,孙洪赞,曹河圻.1999—2019年法医学科获国家自然科学基金资助情况[J].法医学杂志,2019,35(06):754-758.
5. 陈莉坚,练勇伶,李丽增,岳霞,乔东访,李冬日,王慧君,王起.291例涉及死亡的医疗损害案件回顾性分析[J].法医学杂志,2019,35(06):701-705.
6. 黄庆万,李嘉豪,郑明超,张旭辉,付丽锟,岳霞,王起.基于学生视角的法医学PBL教学的反馈与应用探讨[J].中国法医学杂志,2019,34(03):275-278.
7. 张旭辉,李嘉豪,黄庆万,郑明超,付丽锟,王起.关于法医学专业本科临床实习的调查分析[J].科技创新导报,2019,16(10):229-231+233.
8. 马传鑫,何杰涛,王起.外伤出血基础上因苯丙胺类毒品中毒死亡1例[J].广东公安科技,2018,26(04):78-80.
9. 王起,谢晓利.智能手机进入实体课堂的思考[J].南方医学教育,2018(3):27-29.
10. 朱志琼,刘晋岑,王起.浅谈医学院校法医专业开设模拟出庭训练课[J].医学教育研究与实践,2018,26(02):217-219+274.
11. 朱志琼,刘晋岑,王起.浅谈医学院校法医专业开设模拟出庭训练课[J].医学教育研究与实践,2018,26(02):217-219+274.
12. 刘晋岑,吕昊品,彭智勇,叶明园,徐迪,王起. 提高法医学专业本科生人文素养的思考[J]. 南方医学教育,2017,28(4):17-19+27.
13. 杜思昊,李冬日,王慧君,王起. RT-qPCR技术在法医病理学研究中的应用[J]. 法医学杂志,2017,33(05):526-531.
14. 黄滨,薛冶,谭晓辉,王起. 扫描电镜X线能谱检测在诊断电击伤(死)中的应用[J]. 广东公安科技,2017,25(03):71-72.
15. 陈莉坚,赵铁岭,宋健文,岳霞,王慧君,王起.水电解质紊乱致脑死亡医疗损害鉴定1例[J/OL].法医学杂志,2017,33(04):420-421+423.
16. 刘晋岑,王起.医学院校法医学本科生业务见习的思考[J].医学教育研究与实践,2017,25(01):25-28.
17. 蓝伟雄,何杰涛,谭晓辉,王起.免疫缺陷性疾病基础上病毒性肺炎死亡1例[J].广东公安科技,2016,24(04):69-70.
18. 王起,谢晓利,刘云岗.在医科大学开设《生活方式与健康》选修课的体会[J/OL].中国健康教育,2016,32(06):574-575.
19. 马宏声,金洪年,薛冶,李佳,乔东访,李冬日,王起.冠状动脉肌桥引起心源性猝死1例[J].中国法医学杂志,2016,31(03):303-304.
20. 郭炜,李佳,金洪年,谭晓辉,李冬日,王起.致心律失常型右心室心肌病死亡1例[J].中国法医学杂志,2016,31(02):212-213.
21. 王起,官大威,赵锐,彭雪,张建军,杨大利.大鼠骨骼肌挫伤愈合过程中caspase-3的表达及时间规律[J].法医学杂志,2008,(01):5-7+11+81.
参编教材：
法医尸检手册，人民卫生出版社，2021
法医学，人民卫生出版社，2021
环境损害相关法医学司法鉴定，人民卫生出版社，2021
Forensic Medicine，郑州大学出版社，2020
法医学（第2版），人民卫生出版社，2018
Forensic Medicine，人民卫生出版社，2017
医疗损害鉴定与防范新进展，人民卫生出版社， 2017
法医病理学实验指导（第2版），人民卫生出版社，2016
法医学，北京大学医学出版社，2013
Apoptosis and Medicine, IntechOpen, London，2012
