31F98


姓名:陈玲

电子邮箱:lingpzy@163.com

工作单位:南方医科大学法医学院

职称:主任法医师

导师资格:博士生导师


陈玲,博士,主任法医师,博士生导师,博士后合作导师。自2007年以来一直在南方医科大学从事教学、科研和司法鉴定工作。主持高等教育教学研究和改革项目1项,参编人卫版教材1部,指导本科生获大学生创新训练项目15项,指导研究生获广东省优秀学生1次。主要研究方向为遗传标记的开发和检测、微生物鉴识理论和应用研究,主持国家自然科学基金2项、省部级等其他科研项目9项,以第一作者或通讯作者发表论文53篇、其中SCI论文收录42篇,申请发明专利3项,以主要完成人获广东省科技进步一等奖1项、广东省科技进步二等奖1项、公安部科学技术二等奖1项。承担2万余宗检案,在疑难案件鉴定方面积累了丰富经验。现为广东省刑事技术/司法鉴定资质认定主任评审员,广东省司法鉴定质量工作委员会副主任委员。


主持的科研项目:

[1] 国家自然科学基金面上项目,82271927,《基于16S rDNA微单倍型标记的混合斑体液识别和身份溯源研究》,2023.01-2026.12,53万元,在研,主持;

[2] 国家自然科学基金青年项目,81501627,《DDIT4-mTOR信号轴介导的自噬在METH神经毒性损伤中的作用及其机制》,2016.01-2018.12,21.6万元,结题,主持;

[3] 广东省自然科学基金面上项目, No.2020A1515010938,《微生物群落用于人体组织体液溯源的探索研究》,2019.10-2022.09,10.0万元,在研,主持;

[4] 广东省基础与应用基础研究基金项目, No.2022A1515012011,《人体皮肤微生物标记的甄选和用于法医组织体液溯源的效能评估》,2019.10-2022.09,10.0万元,在研,主持;

[5] 广州市科技计划项目, No.2019030016,《新一代测序技术的法医学应用与研究》,2019.07-2022.06,40.0万元,结题,横向课题主持;

[6] 法医遗传学公安部重点实验室开放课题, No.2015FGKFKT03,《27-plex SNPs复合扩增系统在非洲黑人和华南地区人群中的验证与应用研究》,2015.10-2017.09,10.0万元,结题,主持;

[7] 广东省医学科研基金, No.2014A030310025,《DDIT4在METH损伤作用中的分子机制》,2015.07-2017.06,1.0万元,结题,主持;

[8] 现场物证溯源技术国家工程实验室开放课题, No. 2018NELKFKT 16,《74重AISNPs 体系在中国南方少数民族和越南人群中的应用研究》,2018.04-2020.08,6.0万元,结题,主持;

[9] 上海市法医学重点实验室开放课题, No.KF1914,《基于16SrDNA高通量测序筛选阴道分泌物和唾液微生物标记的研究》,2019.04-2021.03,5.0万元,在研,主持;

[10] 广州市科技计划项目,No. 202102080308,《基于珠江水体微生物/代谢组分析推断溺死地点的探索研究》,2021.04-2023.03,5.0万元,在研,主持;


申请的发明专利:

[1] 一种基于微生物标记鉴识唾液与阴道分泌物的试剂盒及其应用(CN202111082672.8)

[2] 一种人类常染色体和Y染色体InDel遗传多态性位点复合扩增试剂盒及其应用(CN201710136758.1)

[3] 基于224个InDel和57个SNP位点的二代测序检测体系(202210237635)


获得的科技奖励:

[1] 广东省科技进步一等奖,Y染色体遗传标记法医检验关键技术及体系建立与规模应用(粤府证【2021】432号)

[2] 广东省科技进步二等奖,脱落细胞DNA分型及法医学应用研究(粤府证【2013】2518号)

[3] 公安部科学技术二等奖,高分辨InDel检验体系建立与法医学应用(2022GA2-02).


代表性论文:

[1] Litao Huang, Liting Deng, Changhui Liu, Enping Huang, Xiaolong Han, Cheng Xiao, Xiaomin Liang, Huilin Sun*, Chao Liu*, Ling Chen*. Fecal microbial signatures of healthy Han individuals from three bio-geographical zones in Guangdong. Front Microbiol, . 2022 Aug 8;13:920780. doi: 10.3389/fmicb.2022.920780. eCollection 2022.

[2] Liang X, Han X, Liu C, Du W, Zhong P, Huang L, Huang M, Fu L, Liu C*, Chen L*. Integrating the salivary microbiome in the forensic toolkit by 16S rRNA gene: potential application in body fluid identification and biogeographic inference. Int J Legal Med. 2022 May 10. doi: 10.1007/s00414-022-02831-z. Epub ahead of print. PMID: 35536322.

[3] Yao T, Wang Z, Liang X, Liu C, Yu Z, Han X, Liu R, Liu Y, Liu C*, Chen L*. Signatures of vaginal microbiota by 16S rRNA gene: potential bio-geographical application in Chinese Han from three regions of China. Int J Legal Med. 2021 Jul;135(4):1213-1224. doi: 10.1007/s00414-021-02525-y. Epub 2021 Feb 17. PMID: 33594458.

[4] Yao T, Han X, Guan T, Wang Z, Zhang S, Liu C, Liu C*, Chen L*. Effect of indoor environmental exposure on seminal microbiota and its application in body fluid identification. Forensic Sci Int. 2020 Sep;314:110417. doi: 10.1016/j.forsciint.2020.110417. Epub 2020 Jul 15. PMID: 32702532.

[5] Yao T, Han X, Guan T, Zhai C, Liu C, Liu C, Zhu B*, Chen L*. Exploration of the microbiome community for saliva, skin, and a mixture of both from a population living in Guangdong. Int J Legal Med. 2021 Jan;135(1):53-62. doi: 10.1007/s00414-020-02329-6. Epub 2020 Jun 24. PMID: 32583081.

[6] Chen L#, Pan X, Wang Y, Du W, Wu W, Tang Z, Xiao C, Han X, Liu C, Liu C. Development and Validation of a Forensic Multiplex System With 38 X-InDel Loci. Front Genet. 2021 Aug 17;12:670482. doi: 10.3389/fgene.2021.670482. PMID: 34484288; PMCID: PMC8416044.

[7] Xiao C, Yang X, Liu H, Liu C, Yu Z, Chen L*, Liu C*. Validation and forensic application of a new 19 X-STR loci multiplex system. Leg Med (Tokyo). 2021 Nov;53:101957. doi: 10.1016/j.legalmed.2021.101957. Epub 2021 Aug 21. PMID: 34481193.

[8] Lu H, Qiu P, Liu C, Du W, Chen L*. Genetic polymorphism of 21 non-CODIS STR loci for Guangdong (Southern China) Han population. Forensic Sci Int Genet. Forensic Sci Int Genet. 2017 Mar;27:180-181. doi: 10.1016/j.fsigen.2016.11.005.

[9] Xiao C, Peng Z, Chen F, Yan H, Zhu B, Tai Y, Qiu P, Liu C, Song X, Wu Z, Chen L*. Mutation analysis of 19 commonly used short tandem repeat loci in a Guangdong Han population. Leg Med (Tokyo). 2018 May;32:92-97. doi: 10.1016/j.legalmed.2018.03.005. Epub 2018 Mar 23. PMID: 29625275.

[10] Du W, Feng P, Huang H, Wu W, Zhang L, Guo Y, Liu C, Liu H, Liu C*, Chen L*. Technical note: developmental validation of a novel 6-dye typing system with 36 Y-STR loci. Int J Legal Med. 2019 Jul;133(4):1015-1027. doi: 10.1007/s00414-018-1864-y. Epub 2018 May 30. PMID: 29846776.

[11] Chen L#, Du W, Wu W, Yu A, Pan X, Feng P, Feng C, Li C, Xu L, Liu C, Liu C. Developmental validation of a novel six-dye typing system with 47 A-InDels and 2 Y-InDels. Forensic Sci Int Genet. 2019 May;40:64-73. doi: 10.1016/j.fsigen.2019.02.009. Epub 2019 Feb 12. PMID: 30776773.

[12] Huang H, Yao T, Wu W, Zhai C, Guan T, Song Y, Sun Y, Xiao C, Liang P, Chen L*. Specific microbes of saliva and vaginal fluid of Guangdong Han females based on 16S rDNA high-throughput sequencing. Int J Legal Med. 2019 May;133(3):699-710. doi: 10.1007/s00414-018-1986-2. Epub 2019 Jan 4. PMID: 30610448.

[13] Peng H, Li X, Yao T, Huang H, Xiao C, Wu W, Chen L*. Forensic effectiveness and genetic distribution of 20 non-CODIS STRs and D3S1358 in Guangdong Han population. Int J Legal Med. 2020 Jul;134(4):1319-1321. doi: 10.1007/s00414-019-02094-1.

[14] Chen L#, Pan X, Wang Y, Du W, Wu W, Tang Z, Xiao C, Han X, Liu C, Liu C. Development and Validation of a Forensic Multiplex System With 38 X-InDel Loci. Front Genet. 2021 Aug 17;12:670482. doi: 10.3389/fgene.2021.670482. eCollection 2021.

[15] Chen L#, Huang E, Wang H, Qiu P, Liu C. RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells. Brain Res. 2013 Jul 12;1521:59-67. doi: 10.1016/j.brainres.2013.05.016. Epub 2013. PMID: 23688541