师资队伍

1、中华预防医学会生物统计分会委员

2、中国卫生信息学会统计理论与方法专业委员会委员

3、“器官衰竭防治”国家重点实验室PI

4、粤港澳污染物暴露与健康联合实验室科研骨干

5、SCI期刊《BMC Genomics》（影响因子4.547）编委

6、International Biometric Society会员

博士

1、遗传统计学

2、生物统计学

3、卫生统计学

4、大数据分析

5、应用统计学

高等代数、遗传统计学、临床试验设计与统计分析、应用回归分析、生物统计学、SPSS软件应用、医学统计学、护理学科研方法

1、基于家系和独立个体混合数据的精准定位X染色体数量性状位点统计方法研究，广东省自然科学基金面上项目，项目负责人，基金编号：2023A1515011242，资助总金额：10万元，资助时间：2023年1月至2025年12月。

2、X染色体偏倚失活系数的稳健估计及不同失活模式下有效的复杂疾病易感基因定位的统计方法研究，国家自然科学基金面上项目，项目负责人，基金编号：2021年（82173619），资助总金额：71.5万元（其中直接经费：55万元），资助时间：2022年1月至2025年12月。

3、X染色体失活的统计度量及合并X染色体失活与印记效应的关联分析研究，国家自然科学基金面上项目，项目负责人，基金编号：2017年（81773544），资助总金额：66万元（其中直接经费：55万元），资助时间：2018年1月至2021年12月。

4、VP1蛋白A289T变异、VIM多态性与EV71神经系统感染的相关性和机制研究，国家自然科学基金面上项目，第一参与人，基金编号：2015年（81573207），资助金额：68.4万元，资助时间：2016年01至2019年12月。

5、X 伴性遗传病印记效应检测及其关联分析的统计方法研究，国家自然科学基金面上项目，项目负责人，基金编号：2013年（81373098），资助金额：65万元，资助时间：2014年1月至2017年12月。

6、印记基因检测及基于印记效应的疾病易感基因定位的统计方法研究，国家自然科学基金面上项目，项目负责人，基金编号：2010年（81072386），资助金额：34万元，资助时间：2011年1月至2013年12月。

7、X染色体上定位致病印记基因的统计方法研究，广东省科技计划项目，项目负责人，基金编号：2013B021800038，资助时间：2013年12月至2016年11月，资助金额：5万元。

8、HWD下单倍型频率估计方法研究，南方医科大学高层次人才引进启动基金，资助金额：5万元，资助时间：2010年3月至2011年4月。

9、带干扰的广义复合泊松风险模型研究，湖南省教育厅资助项目，第一参与者，基金编号：08C667，资助时间：2009年至2010年。

[1] Yi-Fan Kong#, Shi-Zhu Li#, Kai-Wen Wang, Bin Zhu, Yu-Xin Yuan, Meng-Kai Li, Ji-Yuan Zhou*(通讯作者). An Efficient Bayesian Method for Estimating the Degree of the Skewness of X Chromosome Inactivation Based on the Mixture of General Pedigrees and Unrelated Females. Biomolecules. 2023, 13(3): 543.

[2] Kai-Wen Wang#, Yu-Xin Yuan#, Bin Zhu#, Yi Zhang,Yi-Fang Wei, Fan-Shuo Meng, Shun Zhang, Jing-Xuan Wang, Ji-Yuan Zhou*(通讯作者). X chromosome-wide association study of quantitative biomarkers from the Alzheimer’s Disease Neuroimaging Initiative Study. Frontiers in Aging Neuroscience. 2023, 15:1277731.

[3] Peizhen Zhao, Ziying Yang, Ye Zhang, Jinmei Chen, Xuezhen Fu, Weiming Tang*, Jiyuan Zhou*(共同通讯作者). Prevalence of syphilis and risk factors among HIV-positive men who have sex with men in Guangdong province. Frontiers in Public Health. 2022, 10:1025221.

[4] Zi-Ying Yang#, Wei Liu#, Yu-Xin Yuan#, Yi-Fan Kong, Pei-Zhen Zhao, Wing K. Fung*, Ji-Yuan Zhou*(共同通讯作者). Robust association tests for quantitative traits on the X chromosome. Heredity. 2022, 129(4):244–256.

[5] Wen-Yi Yu#, Yu Zhang#, Meng-Kai Li, Zi-Ying Yang, Wing Kam Fung, Pei-Zhen Zhao and Ji-Yuan Zhou*(通讯作者) BEXCIS: Bayesian methods for estimating the degree of the skewness of X chromosome inactivation. BMC Bioinformatics. 2022, 23:193.

[6] Meng-Kai Li#, Yu-Xin Yuan#, Bin Zhu, Kai-Wen Wang, Wing Kam Fung and Ji-Yuan Zhou*(通讯作者). Gene-based methods for estimating the degree of the skewness of X chromosome inactivation. Genes. 2022, 13(5):827.

[7] Yi-Fan Kong#, Meng-Kai Li#, Yu-Xin Yuan, Zi-Ying Yang, Wen-Yi Yu, Pei-Zhen Zhao and Ji-Yuan Zhou*(通讯作者). Detection of Parent-of-Origin Effects for the Variants Associated with Behavioral Disinhibition in the MCTFR Data. Frontiers in Genetics. 2022, 13: 831685.

[8] 孔艺凡，李锦，周基元*（通讯作者）. 基于家系数据合并X染色体失活的数量性状关联分析方法研究. 中国卫生统计. 2022, 39(5):659-662+668.

[9] Peizhen Zhao, Ziying Yang, Baohui Li, Mingzhou Xiong, Ye Zhang, Jiyuan Zhou*(共同通讯作者), Cheng Wang*. Simple-to-use nomogram for predicting the risk of syphilis among MSM in Guangdong Province: results from a serial cross-sectional study. BMC Infectious Diseases. 2021, 21:1199.

[10] Pei Zhen Zhao, Ya Jie Wang, Huan Huan Cheng,Ye Zhang, Wei Ming Tang, Fan Yang, Wei Zhang, Ji Yuan Zhou*(共同通讯作者), Cheng Wang*. Uptake and Correlates of Chlamydia and Gonorrhea Testing among Female Sex Workers in Southern China: A Cross-sectional Study. BMC Public Health. 2021, 21:1477.

[11] Bao-Hui Li#, Wen-Yi Yu#, Ji-Yuan Zhou*(通讯作者). A statistical measure for the skewness of X chromosome inactivation for quantitative traits and its application to the MCTFR data. BMC Genomic Data. 2021, 22:24.

[12] Xiaofeng Zhao, Fangfang Zuo, Ensheng Chen, Yanan Bi, Yanyan Cao, Yi Yuan, Kaiqin Li, Yanan Xuan, Libo Li, Lijuan Wan, Xiangqun Zhang, Feifei Yan, Jiyuan Zhou, Kun Yin, Changhong Xiao*. Photodynamic therapy for synovial hyperplasia in patients with refractory rheumatoid arthritis: a study protocol for a randomized, double-blind, blank-controlled prospective trial. Trials, 2021, 22(1): 685.

[13] 杨梓滢, 余雯薏, 张玉, 周基元*(通讯作者). 一种基于MOVER法中介效应置信区间的构造方法. 中国卫生统计. 2021, 38(2): 204-207+214.

[14] Jiazhen Zheng#, Rui Zhou#, Fengjuan Chen#, Guofang Tang, Keyi Wu, Furong Li, Huamin Liu, Jianyun Lu, Jiyuan Zhou, Ziying Yang, Yuxin Yuan, Chunliang Lei*, Xianbo Wu*. Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: a prospective cohort study. PLOS Neglected Tropical Diseases. 2020, 14(8): e0008648.

[15] Yu Zhang#, Si-Qi Xu#, Wei Liu, Wing Kam Fung, Ji-Yuan Zhou*(通讯作者). A robust test for X-chromosome genetic association accounting for X-chromosome inactivation and imprinting. Genetics Research. 2020, 102:e2,1-12.

[16] Peng Wang, Si-Qi Xu, Bei-Qi Wang, Wing K. Fung*, Ji-Yuan Zhou*(共同通讯作者). A robust and powerful test for case-control genetic association study on X chromosome. Statistical Methods in Medical Research. 2019, 28(10-11): 3260-3272.

[17] Zhijiang Liang, Yin Yang, Jin Li, Xinhong Zhu, Zengliang Ruan, Shuilian Chen, Guanhao Huang, Hualiang Lin*, Ji-Yuan Zhou*(共同通讯作者), Qingguo Zhao*. Migrant population is more vulnerable to the effect of air pollution on preterm birth: results from a birth cohort study in seven Chinese cities. International Journal of Hygiene and Environmental Health. 2019, 222(7): 1047-1053.

[18] Peng Wang#, Yu Zhang#, Bei-Qi Wang, Jian-Long Li, Yi-Xin Wang, Dongdong Pan, Xian-Bo Wu, Wing Kam Fung, Ji-Yuan Zhou*(通讯作者). A statistical measure for the skewness of X chromosome inactivation based on case-control design. BMC Bioinformatics. 2019, 20:11.

[19] Wei Liu, Bei-Qi Wang, Guojun Liu-Fu, Wing Kam Fung*, Ji-Yuan Zhou*(共同通讯作者). X-chromosome genetic association test incorporating X chromosome inactivation and imprinting effects. Journal of Genetics. 2019, 98:99.

[20] Pui Yin Lau#, Kar Fu Yeung#, Ji-Yuan Zhou*(共同通讯作者), Wing Kam Fung*. Two powerful tests for parent-of-origin effects at quantitative trait loci on X chromosome. Human Heredity. 2017/2018, 83(5): 250–273.

[21] Ji-Yuan Zhou*(共同通讯作者), Xiao-Ping You, Ran Yang, Wing K Fung*. Detection of imprinting effects for qualitative traits on X chromosome based on nuclear families. Statistical Methods in Medical Research. 2018, 27(8): 2329-2343.

[22] Zhijiang Liang#, Peng Wang#, Qingguo Zhao, Bei-Qi Wang, Yuanzhu Ma, Hualiang Lin, Jianpeng Xiao, Ji-Yuan Zhou*(通讯作者). Effect of the 2008 cold spell on preterm births in two subtropical cities of Guangdong Province, Southern China. Science of the Total Environment. 2018, 642:307–313.

[23] Wing K Fung, KexinYu, Yingrui Yang, Ji-Yuan Zhou*(通讯作者）. Efficient Monte Carlo evaluation of resampling-based hypothesis tests with applications to genetic epidemiology. Statistical Methods in Medical Research. 2018, 27(5): 1437-1450.

[24] Qi-Lei Zou#, Xiao-Ping You#, Jian-Long Li, Wing Kam Fung*, Ji-Yuan Zhou*(共同通讯作者). A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees. BMC Bioinformatics. 2018, 19:8.

[25] Si-Qi Xu, Yu Zhang, Peng Wang, Wei Liu, Xian-Bo Wu*, Ji-Yuan Zhou*(共同通讯作者). A statistical measure for the skewness of X chromosome inactivation based on family trios. BMC Genetics. 2018, 19: 109.

[26] Ying Tang, Aimin Chen, Shuzhen Zhu, Li Yang, Jiyuan Zhou, Suyue Pan, Min Shao, Lianxu Zhao*. Repetitive transcranial magnetic stimulation for depression after basal ganglia ischaemic stroke: protocol for a multicentre randomised double-blind placebo-controlled trial. BMJ Open. 2018, 8(2):e018011.

[27] 王北琪，汪鹏，尹平，周基元*（通讯作者）. 偏态分布下多样本变异系数比较的平方秩检验. 中国卫生统计. 2018, 35(4): 515-517.

[28] Jian-Long Li, Peng Wang, Wing Kam Fung*, Ji-Yuan Zhou*(共同通讯作者). Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees. BMC Genetics. 2017, 18:90.

[29] Kexin Yu, Ji-Yuan Zhou*(共同通讯作者), Wing K Fung*. Detection of imprinting effects for quantitative traits on X chromosome using nuclear families with multiple daughters. Annals of Human Genetics. 2017, 81(4): 147-160.

[30] Xiao-Ping You, Qi-Lei Zou, Jian-Long Li, Ji-Yuan Zhou*(通讯作者）. Likelihood Ratio Test for Excess Homozygosity at Marker Loci on X Chromosome. PLoS ONE. 2015, 10(12):e0145032.

[31] Ji-Yuan Zhou*(共同通讯作者）, Hai-Qiang He, Xiao-Ping You, Shao-Zhan Li, Ping-Yan Chen, and Wing Kam Fung*. A powerful association test for qualitative traits incorporating imprinting effects using general pedigree data. Journal of Human Genetics. 2015, 60(2):77-83.

[32] 李剑龙，陈方尧，李丹玲，周基元*（通讯作者），陈平雁．具有相关关系的灵敏度和特异度的Monte Carlo模拟方法研究．中国卫生统计．2015, 32(3):417-420.

[33] Hai-Qiang He, Wei-Gao Mao, Dongdong Pan, Ji-Yuan Zhou*（通讯作者）, Ping-Yan Chen, and Wing Kam Fung. Detection of parent-of-origin effects for quantitative traits using general pedigree data. Journal of Genetics. 2014, 93(2):339-347.

[34] Qiong Cao, Di Xie, Jiangmei Liu, Hongyan Zou, Yinze Zhang, Hong Zhang, Zhimei Zhang, Hao Xue, Jiyuan Zhou, Pingyan Chen. HLA Polymorphism and Susceptibility to End-Stage Renal Disease in Cantonese Patients Awaiting Kidney Transplantation. PLoS ONE. 2014, 9(3):e90869.

[35] 汪鹏，周基元*（通讯作者）．非中心t分布非中心参数的最大似然估计．统计与决策．2014，第15期，9-13页.

[36] Wei-Gao Mao, Hai-Qiang He, Yan Xu, Ping-Yan Chen, and Ji-Yuan Zhou*(通讯作者）. Powerful Haplotype-Based Hardy-Weinberg Equilibrium Tests for Tightly Linked Loci. PLoS ONE. 2013, 8(10):e77399.

[37] Dongdong Pan, Wen-Jun Xiong, Ji-Yuan Zhou, Ying Pan, Guoli Zhou, and Wing K. Fung. Robust Joint Analysis with Data Fusion in Two-stage Quantitative Trait Genome-wide Association Studies. Computational and Mathematical Methods in Medicine. 2013, Volume 2013, Article ID 843563, 12 pages.

[38] Fan Xia, Ji-Yuan Zhou, and Wing Kam Fung. Powerful Tests for Association on Quantitative Trait Loci Incorporating Imprinting Effects. Journal of Human Genetics. 2013, 58(6):384-390.

[39] 汪鹏，周怡，周基元*（通讯作者）．多样本变异系数比较的似然比检验．中国卫生统计．2013, 30(3):317-322.

[40] Ji-Yuan Zhou*(共同通讯作者), Wei-Gao Mao, Dan-Ling Li, Yue-Qing Hu*, Fan Xia, and Wing Kam Fung. A Powerful Parent-of-Origin Effects Test for Qualitative Traits Incorporating Control Children in Nuclear Families. Journal of Human Genetics. 2012, 57(8):500-507.

[41] Fan Xia, Ji-Yuan Zhou, and Wing Kam Fung. A Powerful Approach for Association Analysis Incorporating Imprinting Effects. Bioinformatics. 2011, 27(18):2571-2577.

[42] Feng He, Ji-Yuan Zhou(通讯作者、共同第一作者), Yue-Qing Hu, Fengzhu Sun, Jingyuan Yang, Shili Lin, and Wing Kam Fung. Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families With Multiple Children. American Journal of Epidemiology. 2011, 174(2):226-233.

[43] Yue-Qing Hu, and Ji-Yuan Zhou. Inferring haplotype/disease association by joint use of case-parents trios and case-parent pairs. Annals of Human Genetics. 2010, 74(3):263-274.

[44] Ji-Yuan Zhou, Jie Ding, Wing K. Fung, and Shili Lin. Detection of parent-of-origin effects using general pedigree data. Genetic Epidemiology. 2010, 34(2):151-158.

[45] Ji-Yuan Zhou, Shili Lin, Wing K. Fung, and Yue-Qing Hu. Detection of parent-of-origin effects in complete and incomplete nuclear families with multiple affected children using multiple tightly linked markers. Human Heredity. 2009, 67(2):116-127.

[46] Ji-Yuan Zhou, Yue-Qing Hu, Shili Lin, and Wing K. Fung. Detection of parent-of-origin effects based on complete and incomplete nuclear families with multiple affected children. Human Heredity. 2009, 67(1):1-12.

[47] Yue-Qing Hu, Ji-Yuan Zhou, Fengzhu Sun, and Wing K. Fung. The transmission disequilibrium test and imprinting effects test based on case-parent pairs. Genetic Epidemiology. 2007, 31(4):273-287.

[48] Yue-Qing Hu, Ji-Yuan Zhou, and Wing K. Fung. An extension of the transmission disequilibrium test incorporating imprinting. Genetics. 2007, 175(3):1489-1504.

[49] Ji-Yuan Zhou, Yue-Qing Hu, and Wing K. Fung. A simple method for detection of imprinting effects based on case-parents trios. Heredity. 2007, 98(2):85-91.

[50] 周基元，张新华. X伴性遗传疾病易感性基因的定位问题. 数学理论与应用. 2005, 25(4):44-48.

1、2015年6月，编委：《医学应用统计分析（SAS、SPSS版）》，主编：陈青山；人民卫生出版社。ISBN：978-7-117-20876-5/R.20877

2、2003年2月，参编著作一部：《数学分析选讲》，邹中柱、周基元；湖南科学技术出版社。ISBN：7-5357-3655-6/G.467