研究方向:神经变性性疾病--自噬与突触功能
科研项目:国家自然科学基金面上项目: α-synuclein诱导线粒体稳态失衡在帕金森病分子病理机制中的作用研究
国家自然科学基金面上项目负责人
成果奖励:
专利/Patents:
代表论文:
1.Role of c-Abl- GSK3β signaling in MPP+-induced autophagy-lysosomal dysfunction. toxicological sciences. 2018 Sep 1;165(1):232-243.Yixian Ren, Jialong Chen, Xian Wu, Chen Gui, Kanmin Mao, Fei Zou*, Wenjun Li*.(共同通讯)
2.Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018 Jun 13;9(6):700. Jialong Chen, Yixian Ren, Chen Gui, Menglan Zhao, Kanmin Mao, Wenjun Li*, Fei Zou*. (共同通讯)
3.Mitochondrial calcium uniporter-mediated inhibition of 1-methyl-4-phenylpyridinium ions neurotoxicity in PC12 cells. Neuroreport. 2018 May 2;29(7):570-576. Huiling Wang, Menglan Zhao, Jialong Chen, Yixian Ren, Guanghai Wang, Wenjun Li*, Fei Zou*.(共同通讯)
4.TRPC1 is involved in Ca²⁺ influx and cytotoxicity following Pb²⁺ exposure in human embryonic kidney cells. Toxicol Lett. 2014 Aug 17;229(1):52-8. Hongmei Zhang*, Wenjun Li*, Yong Xue, Fei Zou. (共同第一)
5.The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1. Exp Toxicol Pathol. 2013 Nov;65(7-8):1073-81. Wenjun Li*, Minhong Zhang*, Lei Xu, Danmiao Lin, Shaoxi Cai, Fei Zou. (共同第一)
6.Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells. Biosci Rep. 2012 Feb;32(1):83-90.Suxia Sun*, Wenjun Li*, He Zhang, Longying Zha, Yong Xue, Xianbo Wu, Fei Zou.(共同第一)
7.Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase. Cell Prolif. 2012 Apr;45(2):167-75. He Zhang*,Wenjun Li*,Suxia Sun,Shaozhen Yu, Minhong Zhang, Fei Zou. (共同第一)