近5年主持国家自然科学基金面上项目2项，省部级科研项目3项。以一作或通讯作者在《Diabetes Care》 《Chest》等期刊发表SCI论文52篇，个人H指数27，2022年入选斯坦福大学Mendeley Data“全球前2%顶尖科学家榜单”，担任《Annals of Internal Medicine》《BMJ Open》等著名期刊的审稿专家，国家自然科学基金评审专家。
《流行病学》国家级一流课程负责人；曾获省部级教学成果一等奖3项、三等奖2项，培养广东省优秀硕士2人，主编和参编教材５部。目前担任教育部工程中心副主任，广东省重点实验室副主任，广东省卫生学会秘书长、广东省公共卫生与预防医学教指委秘书长、广东省专业学位研究生教育指导委员会委员。
研究领域
1.肠道病原相关疾病的流行病学研究；
2.老年人群健康影响因素流行病学研究。
近五年发表论文：
1. Li FR, Wu KY, Fan WD, Chen GC, Tian H, Wu XB. Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults. Ecotoxicol Environ Saf. 2022 Sep 1;242:113835.
2. Li FR, Hukportie DN, Yang J, Yang HH, Chen GC, Wu XB. Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes. Diabetes Care. 2022 Aug 9:dc220177.
3. Hukportie DN, Li FR, Zhou R, Zheng JZ, Wu XX, Zou MC, Wu XB. Lipid variability and risk of microvascular complications in Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: A post hoc analysis. J Diabetes. 2022 Jun;14(6):365-376.
4. Hukportie DN, Li FR, Zhou R, Zheng JZ, Wu XX, Wu XB. Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial. Diabetes Metab J. 2022 May 10.
5. Liu H, Wang Z, Zou L, Gu S, Zhang M, Hukportie DN, Zheng J, Zhou R, Yuan Z, Wu K, Huang Z, Zhong Q, Huang Y, Wu X. Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study. Front Mol Neurosci. 2022 May 23;15:808209.
6. Zheng J, Huang X, Huang J, Meng B, Li F, Liu H, Chen L, Zhou R, Zou M, Wu X. Associations of Diabetes Status and Hyperglycemia with Symptomatic Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2022 Feb 28.
7. Yang HL, Li FR, Chen PL, Cheng X, Mao C, Wu XB. Tooth Loss, Denture Use, and Cognitive Impairment in Chinese Older Adults: A Community Cohort Study. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):180-187.
8. Wu K, Liu H, Zheng J, Zou L, Gu S, Zhou R, Yuan Z, Huang Z, Wu X. Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity. Front Aging Neurosci. 2022 Jan 6;13:753129.
9. Ma X, Wu K, Li Y, Li S, Cao L, Xie H, Zheng J, Zhou R, Yuan Z, Huang Z, Yuan J, Wu X. Contact tracing period and epidemiological characteristics of an outbreak of the SARS-CoV-2 Delta variant in Guangzhou. Int J Infect Dis. 2022 Apr;117:18-23.
10. Zheng J, Chen F, Wu K, Wang J, Li F, Huang S, Lu J, Huang J, Liu H, Zhou R, Huang Z, Meng B, Yuan Z, Wu X. Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients. PLoS Negl Trop Dis. 2021 Nov 29;15(11):e0009997.
11. Zhou R, Liu HM, Li FR, Yu JR, Yuan ZL, Zheng JZ, Zou LW, Wu XB. Variability in Cardiometabolic and Inflammatory Parameters and Cognitive Decline. Am J Prev Med. 2021 Oct;61(4):e181-e189.
12. Li FR, Yang HL, Zhou R, Zheng JZ, Chen GC, Wu XX, Zou MC, Wang JY, Fu Q, Wu XB. Influence of Diabetes Duration and Glycemic Control on Dementia: A Cohort Study. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):2062-2070.
13. Hukportie DN, Li FR, Zhou R, Zou MC, Wu XX, Wu XB. Association of Predicted Lean Body Mass and Fat Mass With Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus: A Post Hoc Analysis of ACCORD Trial. Front Endocrinol (Lausanne). 2021 Oct 27;12:719666.
14. Li FR, Chen PL, Lv YB, Cheng X, Yang HL, Yin ZX, Zhao F, Zhang XR, Li ZH, Shen D, Mao C, Wu XB, Shi XM. Association Between Plasma 25-hydroxyvitamin D Concentrations and Incident Activities of Daily Living Disability: A Longitudinal Community-Based Cohort Study. J Am Med Dir Assoc. 2021 Sep;22(9):1946-1952.e3.
15. Hukportie DN, Li FR, Zhou R, Zheng JZ, Wu XX, Wu XB. Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne). 2021 Aug 4;12:706845.
16. Li FR, He Y, Yang HL, Liu HM, Zhou R, Chen GC, Wu XX, Zou MC, Wang JY, Wu XB. Isolated systolic and diastolic hypertension by the 2017 American College of Cardiology/American Heart Association guidelines and risk of cardiovascular disease: a large prospective cohort study. J Hypertens. 2021 Aug 1;39(8):1594-1601.
17. Li FR, Yang HL, Zhou R, Zheng JZ, Chen GC, Zou MC, Wu XX, Wu XB. Diabetes duration and glycaemic control as predictors of cardiovascular disease and mortality. Diabetes Obes Metab. 2021 Jun;23(6):1361-1370.
18. Liu H, Zou L, Zhou R, Zhang M, Gu S, Zheng J, Hukportie DN, Wu K, Huang Z, Yuan Z, Wu X. Long-Term Increase in Cholesterol Is Associated With Better Cognitive Function: Evidence From a Longitudinal Study. Front Aging Neurosci. 2021 Jun 17;13:691423.
19. Zhou R, Liu HM, Zou LW, Wei HX, Huang YN, Zhong Q, Gu SY, Chen MF, Wang SL, Sun HX, Wu XB. Associations of Parity With Change in Global Cognition and Incident Cognitive Impairment in Older Women. Front Aging Neurosci. 2022 May 4;14:864128.
20. Zheng J, Zhou R, Meng B, Li F, Liu H, Wu X. Knowledge framework and emerging trends in intracranial aneurysm magnetic resonance angiography: a scientometric analysis from 2004 to 2020. Quant Imaging Med Surg. 2021 May;11(5):1854-1869.
21. Zheng J, Zhou R, Li F, Chen L, Wu K, Huang J, Liu H, Huang Z, Xu L, Yuan Z, Mao C, Wu X. Association between dietary diversity and cognitive impairment among the oldest-old: Findings from a nationwide cohort study. Clin Nutr. 2021 Apr;40(4):1452-1462.
22. Zhou R, Liu HM, Li FR, Yang HL, Zheng JZ, Zou MC, Zou LW, Wu XX, Wu XB. Depression as a Mediator of the Association Between Wealth Status and Risk of Cognitive Impairment and Dementia: A Longitudinal Population-Based Cohort Study. J Alzheimers Dis. 2021;80(4):1591-1601.
23. Zhou R, Li F, Chen G, Fu Q, Gu S, Wu X. Associations between general and abdominal obesity and incident diabetic neuropathy in participants with type 2 diabetes mellitus. J Diabetes. 2021 Jan;13(1):33-42.
24. Li ZH, Zhang XR, Zhong WF, Song WQ, Wang ZH, Chen Q, Liu D, Huang QM, Shen D, Chen PL, Mao A, Zhang D, Yang X, Wu XB, Mao C. Knowledge, attitudes, and practices related to Coronavirus disease 2019 during the outbreak among workers in China: A large cross-sectional study. PLoS Negl Trop Dis. 2020 Sep 17;14(9):e0008584.
25. Zheng J, Zhou R, Chen F, Tang G, Wu K, Li F, Liu H, Lu J, Zhou J, Yang Z, Yuan Y, Lei C, Wu X. Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: A prospective cohort study. PLoS Negl Trop Dis. 2020 Aug 31;14(8):e0008648.
26. Luo L, Liu D, Liao X, Wu X, Jing Q, Zheng J, Liu F, Yang S, Bi H, Li Z, Liu J, Song W, Zhu W, Wang Z, Zhang X, Huang Q, Chen P, Liu H, Cheng X, Cai M, Yang P, Yang X, Han Z, Tang J, Ma Y, Mao C. Contact Settings and Risk for Transmission in 3410 Close Contacts of Patients With COVID-19 in Guangzhou, China : A Prospective Cohort Study. Ann Intern Med. 2020 Dec 1;173(11):879-887.
27. Zheng J, Chen F, Han S, Zhou R, Li F, Liu H, Lu J, Wu X. Recovery of pneumonia in 27 discharged COVID-19 patients with positive virus detection. Quant Imaging Med Surg. 2020 Jul;10(7):1572-1575.
28. Zhou R, Li F, Chen F, Liu H, Zheng J, Lei C, Wu X. Viral dynamics in asymptomatic patients with COVID-19. Int J Infect Dis. 2020 Jul;96:288-290.
29. Su W, Huang S, Zhu H, Zhang B, Wu X. Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection. Viruses. 2020 Apr 8;12(4):414.
30. Li ZH, Zhong WF, Lv YB, Kraus VB, Gao X, Chen PL, Huang QM, Ni JD, Shi XM, Mao C, Wu XB. Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals. Immun Ageing. 2019 Nov 5;16:28.
31. Mao C, Li FR, Yin ZX, Lv YB, Luo JS, Yuan JQ, Mhungu F, Wang JN, Shi WY, Zhou JH, Chen GC, Gao X, Kraus VB, Wu XB, Shi XM. Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years. J Nutr. 2019 Jun 1;149(6):1056-1064.
32. Li ZH, Lv YB, Zhong WF, Gao X, Byers Kraus V, Zou MC, Zhang XR, Li FR, Yuan JQ, Shi XM, Wu XB, Mao C. High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3370-3378.
33. Li FR, Zhang XR, Zhong WF, Li ZH, Gao X, Kraus VB, Lv YB, Zou MC, Chen GC, Chen PL, Zhang MY, Kur AKA, Shi XM, Wu XB, Mao C. Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3345-3354.
34. Zhu H, Cao Y, Su W, Huang S, Lu W, Zhou Y, Gao J, Zhao W, Zhang B, Wu X. Enterovirus A71 VP1 Variation A289T Decreases the Central Nervous System Infectivity via Attenuation of Interactions between VP1 and Vimentin In Vitro and In Vivo. Viruses. 2019 May 22;11(5):467.
35. Xu SQ, Zhang Y, Wang P, Liu W, Wu XB, Zhou JY. A statistical measure for the skewness of X chromosome inactivation based on family trios. BMC Genet. 2018 Dec 5;19(1):109.
36. Cheng Z, Yan Y, Jing S, Li WG, Chen WW, Zhang J, Li M, Zhao S, Cao N, Ou J, Zhao S, Wu X, Cao B, Zhang Q. Comparative Genomic Analysis of Re-emergent Human Adenovirus Type 55 Pathogens Associated With Adult Severe Community-Acquired Pneumonia Reveals Conserved Genomes and Capsid Proteins. Front Microbiol. 2018 Jun 5;9:1180.
37. Li FR, Wu X, Yuan J, Wang J, Mao C, Wu X. Comparison of thoracic endovascular aortic repair, open surgery and best medical treatment for type B aortic dissection: A meta-analysis. Int J Cardiol. 2018 Jan 1;250:240-246.
38. Li FR, Chen GC, Qin J, Wu X. DietaryFish and Long-Chain n-3 Polyunsaturated Fatty Acids Intake and Risk of Atrial Fibrillation: A Meta-Analysis. Nutrients. 2017 Aug 29;9(9):955.
39. Lin R, Zhu B, Zhang Y, Bai Y, Zhi F, Long B, Li Y, Wu Y, Wu X, Fan H. Intranasal immunization with novel EspA-Tir-M fusion protein induces protective immunity against enterohemorrhagic Escherichia coli O157:H7 challenge in mice. Microb Pathog. 2017 Apr;105:19-24.
40. Lin R, Zhang Y, Long B, Li Y, Wu Y, Duan S, Zhu B, Wu X, Fan H. Oral Immunization with Recombinant Lactobacillus acidophilus Expressing espA-Tir-M Confers Protection against Enterohemorrhagic Escherichia coli O157:H7 Challenge in Mice. Front Microbiol. 2017 Mar 15;8:417.
