学术任职
广东省职业健康协会职业健康教育与促进专业委员会委员，中国毒理学会会员
最高学历
北京协和医学院博士（肿瘤学专业）
研究方向
慢性非传染性疾病，是当前我国及世界范围内的主要健康威胁。随着社会老龄化的发展，在可预见的未来慢性病的发病率将持续增加，严重影响公众健康及社会发展。慢性病的发生与生活方式、环境暴露及遗传因素密切相关。本课题组致力于探索器官衰老及纤维化等慢性病发生的共性机制，为常见慢性病的预防及靶向干预提供理论依据。主要研究方向包括：
1. 慢性肾病的发病机制
2. 组织纤维化及衰老的机制及干预
3. 环境因素复合暴露的健康损害、分子机制及预防控制
4. 复杂疾病的遗传易感性
科研项目
国家自然科学基金面上项目：高原低氧条件下小管上皮细胞Wnts经外泌体途径激活间质成纤维细胞β-catenin信号通路在肾纤维化过程中的作用机制研究
广东省自然科学基金面上项目：慢性镉中毒通过抑制PLD1介导的自噬作用引起肾近曲小管损伤的机制研究
广东省医学科研基金项目：循环miRNA多态性与肥胖关系及其机制研究
代表论文
1. Wu, Z., Kuang, Z., Liang, L., Liu, J., Wang, G#., and Zou, F. (2026). TGF-β/LAMB3 axis drives ROS-dependent renal fibrosis under hypoxic conditions. Free. Radic. Biol. Med. 244, 395-409. (Co-corresponding author)
2. Liang, L., Huang, K., Yuan, W., Liu, L., Zou, F., and Wang, G#. (2021). Dysregulations of mir-503-5p and wnt/β-catenin pathway coordinate in mediating cadmium-induced kidney fibrosis. Ecotoxicol. Environ. Saf. 224, 112667.
3. Yuan, W., Liang, L., Huang, K., Deng, Y., Dong, M., Wang, G#., and Zou, F. (2020). MiR-122-5p and mir-326-3p promote cadmium-induced NRK-52e cell apoptosis by downregulating PLD1. Environ. Toxicol. 35, 1334-1342. (Co-corresponding author)
4. Yuan, W., Liu, L., Liang, L., Huang, K., Deng, Y., Dong, M., Chen, J., Wang, G#., and Zou, F. (2020). MiR-122-5p and mir-326-3p: potential novel biomarkers for early detection of cadmium exposure. Gene 724, 144156. (Co-corresponding author)
5. Huang, K., Deng, Y., Yuan, W., Geng, J., Wang, G#., and Zou, F. (2020). Phospholipase d1 ameliorates apoptosis in chronic renal toxicity caused by low-dose cadmium exposure. Biomed Res. Int. 2020, 7091053. (Co-corresponding author)
6. Lemos, D.R., Mcmurdo, M., Karaca, G., Wilflingseder, J., Leaf, I.A., Gupta, N., Miyoshi, T., Susa, K., Johnson, B.G., and Soliman, K., Wang G#., Morizane R., Bonventre J.V., Duffield J.S. (2018). Interleukin-1β activates a MYC-dependent metabolic switch in kidney stromal cells necessary for progressive tubulointerstitial fibrosis. Journal of the American Society of Nephrology : JASN 29, 1690-1705.
7. Wang, H., Zhao, M., Chen, J., Ren, Y., Wang, G#., Li, W., and Zou, F. (2018). Mitochondrial calcium uniporter-mediated inhibition of 1-methyl-4-phenylpyridinium ions neurotoxicity in PC12 cells. Neuroreport 29, 570-576.
8. Ma, Z., Wang, G#., Chen, X., Ou, Z., and Zou, F. (2014). Association of STAT3 common variations with obesity and hypertriglyceridemia: protective and contributive effects. International journal of molecular sciences 15, 12258-12269. (Co-first author)
9. Ou, Z., Wang, G#., Li, Q., Ma, Z., Dai, M., and Zou, F. (2014). CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a chinese han population. Mol. Biol. Rep. 41, 125-130. (Co-first author)
10. Ou, Z., Wang, G#., Li, Q., Ma, Z., Lin, D., Dai, M., and Zou, F. (2013). The genetic polymorphisms of cathepsin s were associated with metabolic disorders in a chinese han population. Gene 526, 385-389. (Co-first author)
11. Dey, S., Maiti, A.K., Hegde, M.L., Hegde, P.M., Boldogh, I., Sarkar, P.S., Abdel-Rahman, S.Z., Sarker, A.H., Hang, B., and Xie, J., Tomkinson A.E, Zhou M., Shen B., Wang G#., Wu C., Yu D., Lin D., Cardenas V., Hazra T.K. (2012). Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA Repair 11, 570-578.
12. Chen, K., Wang, G#., Peng, L., Liu, S., Fu, X., Zhou, Y., Yu, H., Li, A., Li, J., and Zhang, S., et al. (2011). CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease. Int. J. Cancer. 128, 266-273. (Co-first author)
13. Tai, J., Yang, M., Ni, X., Yu, D., Fang, J., Tan, W., Huang, Z., Wu, C., Chen, X., and Wang, G#., et al. (2010). Genetic polymorphisms in cytochrome p450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a chinese population. Cancer genetics and cytogenetics 196, 76-82.
14. Yang, M., Guo, H., Wu, C., He, Y., Yu, D., Zhou, L., Wang, F., Xu, J., Tan, W., and Wang, G#., et al. (2009). Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Hum. Mutat. 30, 1320-1328.
15. Wang, G#., Yu, D., Tan, W., Zhao, D., Wu, C., and Lin, D. (2009). Genetic polymorphism in chemokine CCL22 and susceptibility to helicobacter pylori infection-related gastric carcinoma. Cancer. 115, 2430-2437.
16. Wu, C., Wang, G#., Yang, M., Huang, L., Yu, D., Tan, W., and Lin, D. (2009). Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a chinese population. Mol. Carcinog. 48, 1131-1138.
