教育经历

2013年6月    南京医科大学，博士

2008年6月    山东师范大学，学士

工作经历

2019年-2020年    罗格斯大学医学院，科研教学专员

2014年-2019年    纪念斯隆凯特琳癌症中心，博士后研究员

研究概述

任思强课题组主要借助病毒介导的神经环路示踪、离体多通道全细胞膜片钳、在体钙成像和光遗传学等技术，研究大脑神经环路网络的结构以及生理病理功能。具体研究方向包括：1. 大脑皮层单个神经元起始的神经网络；2. TREM2及小胶质细胞的生理病理功能；3. 杏仁核内微环路的结构和功能。

代表性文章

1. Si-Qiang Ren; Zhizhong Li; Susan Lin; Matteo Bergami; Song-Hai Shi^*; Precise long-range microcircuit to microcircuit communication connects the frontal and sensory cortices, Neuron, 2019, 104(2): 385-401.

2. Siqiang Ren^#; Wen Yao^#; Marc D Tambini; Tao Yin; Kelly A Norris; Luciano D’Adamio^*; Microglia TREM2 R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels, eLife, 2020, 9:e57513.

3. Siqiang Ren; Lionel Breuillaud; Wen Yao; Tao Yin; Kelly A Norris; Simone P Zehntner; Luciano D'Adamio*; TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2 R47H rats, Journal of Biological Chemistry, 2020. Online.

4. Xiaohui Lv; Si-Qiang Ren; Xin-Jun Zhang; Zhongfu Shen; Tanay Ghosh; Anjin Xianyu; Peng Gao; Zhizhong Li; Susan Lin; Yang Yu; Qiangqiang Zhang; Matthias Groszer; Song-Hai Shi; TBR2 Coordinates Neurogenesis Expansion and Precise Microcircuit Organization via Protocadherin 19 in the Mammalian Cortex, Nature Communications, 2019, 10(1):3946.

5. Si-Qiang Ren; Jing-Zhi Yan; Xiao-Yan Zhang; Yun-Fei Bu; Wei-Wei Pan; Wen Yao; Tian Tian; Wei Lu^*; PKCλ Is Critical in AMPA Receptor Phosphorylation and Synaptic Incorporation During LTP, EMBO J, 2013, 32(10): 1365-1380.

6. Jing-Zhi Yan^#; Zhuo Xu^#; Si-Qiang Ren^#; Bin Hu; Wen Yao; Shan-Hui Wang; Su-Yi Liu; Wei Lu^*; Protein Kinase C Promotes N-methyl-D-aspartate (NMDA) Receptor Trafficking by Indirectly Triggering Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Autophosphorylation, Journal of Biological Chemistry, 2011, 286(28): 25187-25200.