教育经历

2004-2008 南方医科大学 医学检验  医学学士

2008-2014 南方医科大学 神经生物学  博士

工作经历

2014 -2017，美国乔治亚医学院，博士后

2017 -2023，广州医科大学，教授

2023-至今，南方医科大学，教授

研究概述

应激是机体在应对各种内外环境及社会、心理因素刺激时出现的适应反应。适度的应激可提高个体警觉水平，促进个体的生存和发展；而长期、过度的负性应激是情绪障碍（诸如焦虑障碍、抑郁症等）发生的重要原因。课题组致力于其病理机制及干预策略研究，发现糖酵解-乳酸信号异常是慢性社交挫败应激诱发抑郁的重要原因，为抑郁症的发生提供了新机制；解析了抗抑郁分子ATP在脑内释放的信号调控机制，并提出了抑郁症的非药物治疗方式，为抗抑郁药物研发及干预策略提供新靶点和新思路；揭示了疼痛应激诱发情绪障碍的关键环路和分子机制，为临床相关疾病的治疗提供了新线索。研究成果以通讯或第一作者发表在Nat Commun、J Clin Invest、Nat Neurosci、J Neurosci、Neuron等知名期刊，多次被同行专家引用和评述。承担国家自然科学基金2项、广东省杰出青年项目1项，获广东省自然科学奖一等奖和“青年珠江学者”称号。

代表性文章

1. Yao S^#, Xu MD^#, Wang Y^#, Zhao ST^#, Wang J, Chen GF, Chen WB, Liu J, Huang GB, Sun WJ, Zhang YY, Hou HL, Li L, Sun XD* (2023) Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice. Nature Communications 2023 14(1):729.

2. Gao F^#, Huang J^#, Huang GB^#, You QL^#, Yao S, Zhao ST, Liu J, Wu CH, Chen GF, Liu SM, Yu ZY, Zhou YL, Ning YP, Liu SQ, Hu BJ, Sun XD* (2023) Elevated prelimibic-cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain. Journal of Clincial Investigation 2023, in press.

3. Sun XD^#*, Li L^#, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, & Mei L (2016) Lrp4 in astrocytes modulates glutamatergic transmission. Nature neuroscience 19(8):1010-1018.

4. Guan YF^#, Huang GB^#, Xu MD^#, Gao F^#, Lin S^#, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan AG*, Sun XD* (2020) Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula. Brain Behavvior and Immunity 88:748-762.

5. Sun XD^#*, Chen WB^#, Sun D^#, Huang J, Li YQ, Pan JX, Wang YN, Zhao K, Dong ZQ, Wang HS, Xiong L, Xuan A, Zhao ST, Pillai A, Xiong WC, & Mei L* (2018) Neogenin in Amygdala for Neuronal Activity and Information Processing. The Journal of neuroscience 38(44):9600-9613.

6. Ren J, Lu CL, Huang J, Fan J, Guo F, Mo JW, Huang WY, Kong PL, Li XW, Sun  LR, Sun XD*, Cao X*. A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors. Journal of neuroscience 42(11):2356-2370.

7. Lu Y^#, Sun XD^#, Hou FQ, Bi LL, Yin DM, Liu F, Chen YJ, Bean JC, Jiao HF, Liu X, Li BM, Xiong WC, Gao TM*, & Mei L* (2014) Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory. Neuron 84(4):835-846.

8. Jiao HF^#, Sun XD^#, Bates R^#, Xiong L, Zhang L, Liu F, Li L, Zhang H-S, Wang S-Q, Xiong M-T, Patel M, Stranahan AM, Xiong W-C, Li B-M*, & Mei L* (2017) Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus. PNAS 114(5):1177-1182.

9. Wang YN^#, Figueiredo D^#, Sun XD^#, Dong ZQ, Chen WB, Cui WP, Liu F, Wang HS, Li HW, Robinson H, Fei EK, Pan BX, Li BM, Xiong WC, & Mei L (2018) Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. PNAS 115(10):2508-2513.