教育经历

2012.8-2018.1, 中国科学院长春应用化学研究所, 博士.

2008.9-2012.6, 湖北大学, 学士

工作经历

2018.1-2023.1, 美国德克萨斯大学达拉斯分校，博士后

研究概述

神经递质和调质对维持大脑正常的生理活动和健康至关重要。解析神经递质和调质在大脑中的功能作用有助于全面深入理解大脑的认知功能和开发新型的治疗脑部疾病的药物。而中枢神经系统的药物递送效率受到多种生理屏障如血脑屏障、血脊髓屏障等。因此，本课题组一方面致力于开发基于智能控释纳米载体的神经调控技术，实现按需精准控制神经递质和调质的脑内释放，研究这些物质的脑内调控功能；另一方面致力于开发克服中枢神经系统生理屏障的技术，为提高药物递送效率和疗效提供新方法，为脑疾病的临床治疗提供新策略。相关成果以第一作者或通讯作者发表于Angewandte Chemie International Edition、Nano Letters等国际知名期刊。

代表性文章

(⁺ co-first author; * corresponding author)

1. Hejian Xiong⁺, Blake A. Wilson⁺, Xiaoqian Ge^+,*, Xiaofei Gao, Qi Cai, Xueqi Xu, Robert Bachoo*, Zhenpeng Qin*. Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles. Nano Letters 2024, 24(5), 1570–1578.

2. Dongquan Xiang⁺, Xinli Han⁺, Jianxiong Li, Jiabing Zhang, Haihua Xiao, Ting Li, Xueling Zhao, Hejian Xiong*, Meng Xu*, Wenzhi Bi*. Combination of IDO Inhibitors and Platinum(IV) Prodrugs Reverses Low Immune Responses to Enhance Cancer Chemotherapy and Immunotherapy for Osteosarcoma. Materials Today Bio 2023, 20, 100675.

3. Hejian Xiong, Kevin A. Alberto, Jonghae Youn, Jaume Taura, Johannes Morstein, Xiuying Li, Yang Wang, Dirk Trauner, Paul A. Slesinger*, Steven O. Nielsen*, Zhenpeng Qin*. Optical control of neuronal activities with photoswitchable nanovesicles. Nano Research 2023, 16(1), 1033−1041. (Inside Cover Feature)

4. Hejian Xiong, Blake A. Wilson, Paul A. Slesinger, Zhenpeng Qin*. Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release. ACS Chemical Neuroscience 2023, 14, 4, 516–523.

5. Hejian Xiong, Emre Lacin, Hui Ouyang, Aditi Naik, Xueqi Xu, Chen Xie, Jonghae Youn, Blake A. Wilson, Krutin Kumar, Tyler Kern, Erin Aisenberg, Daniel Kircher, Xiuying Li, Joseph A. Zasadzinski, Celine Mateo, David Kleinfeld, Sabina Hrabetova, Paul A. Slesinger*, Zhenpeng Qin*. Probing neuropeptide volume transmission in vivo by simultaneous near-infrared light triggered release and optical sensing. Angewandte Chemie International Edition 2022, 61(34), e202206122. (Hot paper)

6. Xueqi Xu, Xiaoqian Ge, Hejian Xiong*, Zhenpeng Qin*. Towards dynamic, anisotropic, high-resolution, and functional measurement in the brain extracellular space. Neurophotonics 2022, 9(3), 032210.

7. Hejian Xiong^#, Xiuying Li^#,*, Peiyuan Kang, John Perish, Frederik Neuhaus, Jonathan Ploski, Sven Kroener, Maria O. Ogunyankin, Jeong Eun Shin, Joseph A. Zasadzinski, Hui Wang, Paul Slesinger, Andreas Zumbuehl*, Zhenpeng Qin*. Near-infrared light triggered-release in deep brain regions using ultra-photosensitive nanovesicles. Angewandte Chemie International Edition 2020, 59(22), 8608-8615.

8. Hejian Xiong, Yanran Li, Haihang Ye, Gang Huang, Dongfang Zhou*, Yubin Huang*. Self-healing Supramolecular Hydrogels through Host-guest Interaction between Cyclodextrin and Carborane. Journal of Materials Chemistry B. 2020, 8(45), 10309-10313.

9. Hejian Xiong, Dongfang Zhou*, Xiaohua Zheng, Yanxin Qi, Yongheng Wang, Xiabin Jing, Yubin Huang*. Stable Amphiphilic Supramolecular Self-assembly Based on Cyclodextrin and Carborane for The Efficient Photodynamic Therapy. Chemical Communications 2017, 53, 3422−3425.