教育经历

1997年，南京大学，学士

2002年，清华大学，硕士

2006年，香港城市大学，博士

工作经历

2006年-2016年，南方医科大学公共卫生学院，讲师/副教授/教授

2016年至今，南方医科大学珠江医院，检验医学部科室主任、教授

2024年至今，南方医科大学深圳医院，院长

研究概述

在人体微生态领域做出了系统性创新工作：首次揭示肠道菌群的地域性，建立普适性菌群靶标挖掘新策略。在肝性脑病、卒中、肾性心衰、克罗恩病、类风湿性关节炎、子痫前期等多种复杂疾病中发现菌群-宿主互作新靶点。以通讯或共同通讯作者在Nature Medicine、Cell Host & Microbe等著名刊物发表研究论文。承担国家重点研发计划、国家自然科学基金杰出青年科学基金、优秀青年科学基金、重点项目、专项项目、广州市脑肠轴重点项目等多项科研课题。

代表性文章

1. He X, Hu M, Xu Y, Xia F, Tan Y, Wang Y, Xiang H, Wu H, Ji T, Xu Q, Wang L, Huang Z, Sun M, Wan Y, Cui P, Liang S, Pan Y, Xiao S, He Y, Song R, Yan J, Quan X, Wei Y, Hong C, Liao W, Li F, El-Omar E, Chen J, Qi X, Gao J, Zhou H. The gut-brain axis underlying hepatic encephalopathy in liver cirrhosis. Nature Medicine. 2025 Feb;31(2):627-638.

2. Yun Zhang, Xuejie Han, Tao Feng, Zewen Li, Hui Yu, Ye Chen, Yunlong Gao, Qianhui Gao, Linwei Zhang, Shanshan Li, Ling Shi, Xiru Zhang, Zhuang Li, Yue Li and Hongwei Zhou. Gut-microbiota-derived indole sulfate promotes heart failure in chronic kidney disease. 2025 Cell Host & Microbe. 2025 Oct 8;33(10):1715-1730.e5.

3. Muxuan Chen, Cancan Qi, Wei Qing, Zuyi Zhou, Yingxuan Zhang, Rongdan Chen, Yi Hou, Jinxia Ou, CALM2004 Consortium Investigators, Yan He & Hongwei Zhou. Vaginal microbiome and sexuallytransmitted pathogens in Chinese reproductive-age women: a multicentre cross-sectional and longitudinal cohort study. Nature Communication. 2025 Nov 14;16(1):10002.

4. Mukeng Hong, Zhuang Li, Haihua Liu, Songyuan Zheng, Fangling Zhang, Junqing Zhu, Hao Shi, Haixing Ye, Zhantu Chou, Lei Gao, Jianxin Diao, Yang Zhang, Dongxin Zhang, Shixian Chen*, Hongwei Zhou*, Juan Li*. Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles. Cell Host & Microbe. 2023 May 10;31(5):798-810.e7.

5. Jie Gao, Xinmei Zhao, Shixian Hu, Zhenhe Huang, Mengyao, Hu, Shaoqin Jin, Bingyun Lu, Kai Sun, Zhang Wang, Jingyuan Fu, Rinse K. Weersma*, Xiaolong He*, Hongwei Zhou*. Gut microbial DL-endopeptidase alleviates Crohn’s disease via the NOD2 pathway. Cell Host & Microbe. 2022 Oct 12;30(10):1435-1449.e9.

6. Kaiyu Xu; Xuxuan Gao; Genghong Xia; Muxuan Chen; Nianyi Zeng; Shan Wang; Chao You; Xiaolin Tian; Huiling Di; Wenli Tang; Pan Li; Huidi Wang; Xiuli Zeng; Chuhong Tan; Fanguo Meng; Hailong Li; Yan He; Hongwei Zhou*; Jia Yin; * Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn, Gut. 2021 Feb 8: gutjnl-2020-323263.

7. He Y, Wu W, Zheng HM, Li P, McDonald D, Sheng HF, Chen MX, Chen ZH, Ji GY, Zheng ZDX, Mujagond P, Chen XJ, Rong ZH, Chen P, Lyu LY, Wang X, Wu CB, Yu N, Xu YJ, Yin J, Raes J, Knight R, Ma WJ*, Zhou HW*. Regional variation greatly limits applications of healthy gut microbiome reference ranges and disease models. Nature Medicine. 2018 Oct;24(10):1532-1535.