教育经历

1985.09-1990.07  第一军医大学，军医系, 学士

1990.09-1993.07  军事医学科学院毒物药物研究所, 药理学，硕士

1993.09-1997.07  军事医学科学院毒物药物研究所，药理学，博士

工作经历

1997.08-1999.09  第二军医大学药学院，药学博士后

1999/10-2002/09 第一军医大学，基础部，副教授

2002/10-2004/08 第一军医大学基础部，副教授，药理学教研室 主任

2004/08-2005/06 南方医科大学基础部，副教授，药理学教研室 主任

2005/07-2005/11 南方医科大学药学院，副教授，药理学教研室 主任

2005/12- 2009/12 南方医科大学药学院，教授，药理学系主任，博士生导师

2010/01-2015/06 南方医科大学药学院，教授，博士生导师；先后担任神经药理学科主任(PI)、药学系主任、神经药理及新药发现学科PI

2015/07-2020/05 南方医科大学中心实验室，主任

2019/12~：          南方医科大学药学院神经系统与代谢疾病药物研究群体  学术负责人

研究概述

主要从事1. 治疗神经精神疾病药物新靶点的创新药物设计与活性评价；2. 神经精神疾病（AD、PD、脑缺血、抑郁症等）的发病机理研究和药物筛选；3. 抗神经退行性疾病的中药成分及其机制研究。近5年以第一/通讯作者论文发表在Redox Biology、Brain Behav Immun、FASEB J、BJP、Neuropharmacology、Psychopharmacology等主流学术刊物上。先后主持国家自然科学基金9项，国家新药创制重大专项2项、省市课题20余项。主持1类抗帕金森病新药的I，II期临床试验及主持1类抗抑郁症新药的I期临床试验。

代表性文章

1. Wei S, Luo M, Wang P, Chen R, Jin X, Xu C, Li C, Lin X, Xu Z, Liu H, Cheng R, Yang W, Cai Y, Xue G, Huang P, Liu Z, Sun H, Xu J, Jiang Q. Charting the spatial transcriptome of the human cerebral cortex at single-cell resolution. Nat Commun. 2025 Aug 19;16(1):7702. doi: 10.1038/s41467-025-62793-9. PMID: 40830090; PMCID: PMC12365125.

2. Xia, C.; Wen, H.; Zheng, L.; Ni, Y.; Bi, H.; Wang, H.; Xu, J.; Zhou, Z.-Z. Discovery of 7-Alkoxybenzofurans as PDE4 Inhibitors with Hepatoprotective Activity in D-GalN/LPS-Induced Hepatic Sepsis. Eur J Med Chem 2024, 275, 116576. https://doi.org/10.1016/j.ejmech.2024.116576.

3. Chen, K.; Xu, B.; Qiu, S.; Long, L.; Zhao, Q.; Xu, J.; Wang, H. Inhibition of Phosphodiesterase 4 Attenuates Aquaporin 4 Expression and Astrocyte Swelling Following Cerebral Ischemia/Reperfusion Injury. Glia 2024, 72 (9), 1629–1645. https://doi.org/10.1002/glia.24572.

4. Chen, K.; Xu, B.; Long, L.; Wen, H.; Zhao, Q.; Tu, X.; Wang, J.; Xu, J.; Wang, H. Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion. Mol Neurobiol 2024. https://doi.org/10.1007/s12035-024-04495-9.

5. Chen, K.; Xu, B.; Xiao, X.; Long, L.; Zhao, Q.; Fang, Z.; Tu, X.; Wang, J.; Xu, J.; Wang, H. Involvement of CKS1B in the Anti-Inflammatory Effects of Cannabidiol in Experimental Stroke Models. Exp Neurol 2024, 373, 114654. https://doi.org/10.1016/j.expneurol.2023.114654.

6. Chen, K.; Xu, B.; Xiao, X.; Long, L.; Zhao, Q.; Fang, Z.; Tu, X.; Wang, J.; Xu, J.; Wang, H. Involvement of CKS1B in the Anti-Inflammatory Effects of Cannabidiol in Experimental Stroke Models. Experimental Neurology 2024, 373, 114654. https://doi.org/10.1016/j.expneurol.2023.114654.

7. Qiu, S.; Xian, Z.; Chen, J.; Huang, P.; Wang, H.; Wang, H.; Xu, J. Microglia Nuclear Receptor Corepressor 1 Deficiency Alleviates Neuroinflammation in Mice. Neuroscience Letters 2024, 822, 137643. https://doi.org/10.1016/j.neulet.2024.137643.

8. Xu, B.; Liu, Z.; Chen, K.; Zhao, Q.; Wen, H.; Lin, J.; Xu, J.; Wang, H.; Wang, H.; Wang, Y. Mitofusin 2 Mediates the Protective Effect of NR6A1 Silencing Against Neuronal Injury in Experimental Stroke Models. Mol Neurobiol 2024. https://doi.org/10.1007/s12035-024-04466-0.

9. Li, X.; Xu, B.; Long, L.; Li, Y.; Xiao, X.; Qiu, S.; Xu, J.; Tian, L.-W.; Wang, H. Phelligridimer A Enhances the Expression of Mitofusin 2 and Protects against Cerebral Ischemia/Reperfusion Injury. Chem Biol Interact 2024, 398, 111090. https://doi.org/10.1016/j.cbi.2024.111090.

10. Niu, B.; Zhao, M.; Gao, X.; Xu, J.; Yu, L. TMT-Based Quantitative Proteomics Analysis of Neuroprotective Effects of Forsythoside A on the MPTP-Induced Parkinson’s Disease Mouse Model. Exp Neurol 2024, 373, 114642. https://doi.org/10.1016/j.expneurol.2023.114642.

11. Huang, J.-X.; Zhu, B.-L.; Xu, J.-P.; Zhou, Z.-Z. Advances in the Development of Phosphodiesterase 7 Inhibitors. Eur J Med Chem 2023, 250, 115194. https://doi.org/10.1016/j.ejmech.2023.115194.

12. Jiang, H.; Li, X.; Xing, Z.; Niu, Q.; Xu, J. Intracellular Activity of Poly (DL-Lactide-Co-Glycolide) Nanoparticles Encapsulated with Prothionamide, Pyrazinamide, Levofloxacin, Linezolid, or Ethambutol on Multidrug-Resistant Mycobacterium Tuberculosis. Curr Drug Deliv 2023, 20 (3), 306–316. https://doi.org/10.2174/1567201819666220511120215.

13. Huang, P.; Wei, S.; Ren, J.; Tang, Z.; Guo, M.; Situ, F.; Zhang, D.; Zhu, J.; Xiao, L.; Xu, J.; Liu, G. MicroRNA-124-3p Alleviates Cerebral Ischaemia-Induced Neuroaxonal Damage by Enhancing Nrep Expression. J Stroke Cerebrovasc Dis 2023, 32 (2), 106949. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106949.

14. Xu, B.-T.; Li, M.-F.; Chen, K.-C.; Li, X.; Cai, N.-B.; Xu, J.-P.; Wang, H.-T. Mito(1) Wei S, Luo M, Wang P, Chen R, Jin X, Xu C, Li C, Lin X, Xu Z, Liu H, Cheng R, Yang W, Cai Y, Xue G, Huang P, Liu Z, Sun H, Xu J, Jiang Q. Charting the spatial transcriptome of the human cerebral cortex at single-cell resolution. Nat Commun. 2025 Aug 19;16(1):7702. doi: 10.1038/s41467-025-62793-9. PMID: 40830090; PMCID: PMC12365125.

15. Xia, C.; Wen, H.; Zheng, L.; Ni, Y.; Bi, H.; Wang, H.; Xu, J.; Zhou, Z.-Z. Discovery of 7-Alkoxybenzofurans as PDE4 Inhibitors with Hepatoprotective Activity in D-GalN/LPS-Induced Hepatic Sepsis. Eur J Med Chem 2024, 275, 116576. https://doi.org/10.1016/j.ejmech.2024.116576.

16. Chen, K.; Xu, B.; Qiu, S.; Long, L.; Zhao, Q.; Xu, J.; Wang, H. Inhibition of Phosphodiesterase 4 Attenuates Aquaporin 4 Expression and Astrocyte Swelling Following Cerebral Ischemia/Reperfusion Injury. Glia 2024, 72 (9), 1629–1645. https://doi.org/10.1002/glia.24572.

17. Chen, K.; Xu, B.; Long, L.; Wen, H.; Zhao, Q.; Tu, X.; Wang, J.; Xu, J.; Wang, H. Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion. Mol Neurobiol 2024. https://doi.org/10.1007/s12035-024-04495-9.

18. Chen, K.; Xu, B.; Xiao, X.; Long, L.; Zhao, Q.; Fang, Z.; Tu, X.; Wang, J.; Xu, J.; Wang, H. Involvement of CKS1B in the Anti-Inflammatory Effects of Cannabidiol in Experimental Stroke Models. Exp Neurol 2024, 373, 114654. https://doi.org/10.1016/j.expneurol.2023.114654.

19. Chen, K.; Xu, B.; Xiao, X.; Long, L.; Zhao, Q.; Fang, Z.; Tu, X.; Wang, J.; Xu, J.; Wang, H. Involvement of CKS1B in the Anti-Inflammatory Effects of Cannabidiol in Experimental Stroke Models. Experimental Neurology 2024, 373, 114654. https://doi.org/10.1016/j.expneurol.2023.114654.

20. Qiu, S.; Xian, Z.; Chen, J.; Huang, P.; Wang, H.; Wang, H.; Xu, J. Microglia Nuclear Receptor Corepressor 1 Deficiency Alleviates Neuroinflammation in Mice. Neuroscience Letters 2024, 822, 137643. https://doi.org/10.1016/j.neulet.2024.137643.

21. Xu, B.; Liu, Z.; Chen, K.; Zhao, Q.; Wen, H.; Lin, J.; Xu, J.; Wang, H.; Wang, H.; Wang, Y. Mitofusin 2 Mediates the Protective Effect of NR6A1 Silencing Against Neuronal Injury in Experimental Stroke Models. Mol Neurobiol 2024. https://doi.org/10.1007/s12035-024-04466-0.

22. Li, X.; Xu, B.; Long, L.; Li, Y.; Xiao, X.; Qiu, S.; Xu, J.; Tian, L.-W.; Wang, H. Phelligridimer A Enhances the Expression of Mitofusin 2 and Protects against Cerebral Ischemia/Reperfusion Injury. Chem Biol Interact 2024, 398, 111090. https://doi.org/10.1016/j.cbi.2024.111090.

23. Niu, B.; Zhao, M.; Gao, X.; Xu, J.; Yu, L. TMT-Based Quantitative Proteomics Analysis of Neuroprotective Effects of Forsythoside A on the MPTP-Induced Parkinson’s Disease Mouse Model. Exp Neurol 2024, 373, 114642. https://doi.org/10.1016/j.expneurol.2023.114642.

24. Huang, J.-X.; Zhu, B.-L.; Xu, J.-P.; Zhou, Z.-Z. Advances in the Development of Phosphodiesterase 7 Inhibitors. Eur J Med Chem 2023, 250, 115194. https://doi.org/10.1016/j.ejmech.2023.115194.

25. Jiang, H.; Li, X.; Xing, Z.; Niu, Q.; Xu, J. Intracellular Activity of Poly (DL-Lactide-Co-Glycolide) Nanoparticles Encapsulated with Prothionamide, Pyrazinamide, Levofloxacin, Linezolid, or Ethambutol on Multidrug-Resistant Mycobacterium Tuberculosis. Curr Drug Deliv 2023, 20 (3), 306–316. https://doi.org/10.2174/1567201819666220511120215.

26. Huang, P.; Wei, S.; Ren, J.; Tang, Z.; Guo, M.; Situ, F.; Zhang, D.; Zhu, J.; Xiao, L.; Xu, J.; Liu, G. MicroRNA-124-3p Alleviates Cerebral Ischaemia-Induced Neuroaxonal Damage by Enhancing Nrep Expression. J Stroke Cerebrovasc Dis 2023, 32 (2), 106949. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106949.

27. Xu, B.-T.; Li, M.-F.; Chen, K.-C.; Li, X.; Cai, N.-B.; Xu, J.-P.; Wang, H.-T. Mitofusin-2 Mediates Cannabidiol-Induced Neuroprotection against Cerebral Ischemia in Rats. Acta Pharmacol Sin 2023, 44 (3), 499–512. https://doi.org/10.1038/s41401-022-01004-3.

28. Liu, J.; Liu, L.; Zheng, L.; Feng, K.-W.; Wang, H.-T.; Xu, J.-P.; Zhou, Z.-Z. Discovery of Novel 2,3-Dihydro-1H-Inden-1-Ones as Dual PDE4/AChE Inhibitors with More Potency against Neuroinflammation for the Treatment of Alzheimer’s Disease. Eur J Med Chem 2022, 238, 114503. https://doi.org/10.1016/j.ejmech.2022.114503.

29. Xia, C.; He, J.-P.; Feng, K.-W.; Liu, L.; Zheng, L.; Wang, H.-T.; Xu, J.-P.; Zhou, Z.-Z. Discovery of Novel 3-Amino-4-Alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments. ACS Chem Neurosci 2022, 13 (3), 390–405. https://doi.org/10.1021/acschemneuro.1c00762.

30. Ren, J.; Li, C.; Wei, S.; He, Y.; Huang, P.; Xu, J. Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data. Front Genet 2022, 13, 890961. https://doi.org/10.3389/fgene.2022.890961.

31. Li, M.; Xu, B.; Li, X.; Li, Y.; Qiu, S.; Chen, K.; Liu, Z.; Ding, Y.; Wang, H.; Xu, J.; Wang, H. Mitofusin 2 Confers the Suppression of Microglial Activation by Cannabidiol: Insights from in Vitro and in Vivo Models. Brain Behav Immun 2022, 104, 155–170. https://doi.org/10.1016/j.bbi.2022.06.003.

32. Yu, H.; Shao, S.; Xu, J.; Guo, H.; Zhong, Z.; Xu, J. Persimmon Leaf Extract Alleviates Chronic Social Defeat Stress-Induced Depressive-like Behaviors by Preventing Dendritic Spine Loss via Inhibition of Serotonin Reuptake in Mice. Chin Med 2022, 17 (1), 65. https://doi.org/10.1186/s13020-022-00609-4.

33. Liu, H.; Deng, B.; Zhou, H.; Wu, Z.; Chen, Y.; Weng, G.; Zhu, S.; Xu, J.; Wang, H.; Zhou, Z.; Tan, E.-K.; Wang, Q. QEEG Indices Are Associated with Inflammatory and Metabolic Risk Factors in Parkinson’s Disease Dementia: An Observational Study. EClinicalMedicine 2022, 52, 101615. https://doi.org/10.1016/j.eclinm.2022.101615.

34. Cai, N.; Xu, B.; Li, X.; Qin, Y.; Li, M.; Chen, K.; Xu, J.; Wang, H. Roflumilast, a Cyclic Nucleotide Phosphodiesterase 4 Inhibitor, Protects against Cerebrovascular Endothelial Injury Following Cerebral Ischemia/Reperfusion by Activating the Notch1/Hes1 Pathway. Eur J Pharmacol 2022, 926, 175027. https://doi.org/10.1016/j.ejphar.2022.175027.

35. Zhong, J.; Li, M.; Xu, J.; Dong, W.; Qin, Y.; Qiu, S.; Li, X.; Wang, H. Roflupram Attenuates α-Synuclein-Induced Cytotoxicity and Promotes the Mitochondrial Translocation of Parkin in SH-SY5Y Cells Overexpressing A53T Mutant α-Synuclein. Toxicol Appl Pharmacol 2022, 436, 115859. https://doi.org/10.1016/j.taap.2021.115859.

36. Chen, Y.; Shen, M.; Liu, X.; Xu, J.; Wang, C. The Regulation of Glutamate Transporter 1 in the Rapid Antidepressant-Like Effect of Ketamine in Mice. Front Behav Neurosci 2022, 16, 789524. https://doi.org/10.3389/fnbeh.2022.789524.

37. Gong, W.; Luo, C.; Peng, F.; Xiao, J.; Zeng, Y.; Yin, B.; Chen, X.; Li, S.; He, X.; Liu, Y.; Cao, H.; Xu, J.; Long, H. Brahma-Related Gene-1 Promotes Tubular Senescence and Renal Fibrosis through Wnt/β-Catenin/Autophagy Axis. Clin Sci (Lond) 2021, 135 (15), 1873–1895. https://doi.org/10.1042/CS20210447.

38. Liu, J.; Ye, W.; Xu, J.-P.; Wang, H.-T.; Li, X.-F.; Wang, W.-Y.; Zhou, Z.-Z. Discovery of Novel Trimethoxyphenylbenzo[d]Oxazoles as Dual Tubulin/PDE4 Inhibitors Capable of Inducing Apoptosis at G2/M Phase Arrest in Glioma and Lung Cancer Cells. Eur J Med Chem 2021, 224, 113700. https://doi.org/10.1016/j.ejmech.2021.113700.

39. Que, R.; Zheng, J.; Chang, Z.; Zhang, W.; Li, H.; Xie, Z.; Huang, Z.; Wang, H.-T.; Xu, J.; Jin, D.; Yang, W.; Tan, E.-K.; Wang, Q. Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment. Front Immunol 2021, 12, 794770. https://doi.org/10.3389/fimmu.2021.794770.

40. Guo, X.; Deng, B.; Zhong, L.; Xie, F.; Qiu, Q.; Wei, X.; Wang, W.; Xu, J.; Liu, G.; Hon, W. P. T.; Yenari, M. A.; Zhu, S.; Wang, Q. Fibrinogen Is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but Not in Sporadic Cerebral Small Vessel Disease Patients. Aging Dis 2021, 12 (3), 801–811. https://doi.org/10.14336/AD.2020.1110.

41. Lin, R.; Liu, L.; Silva, M.; Fang, J.; Zhou, Z.; Wang, H.; Xu, J.; Li, T.; Zheng, W. Hederagenin Protects PC12 Cells Against Corticosterone-Induced Injury by the Activation of the PI3K/AKT Pathway. Front Pharmacol 2021, 12, 712876. https://doi.org/10.3389/fphar.2021.712876.

42. Xie, J.; Bi, B.; Qin, Y.; Dong, W.; Zhong, J.; Li, M.; Cheng, Y.; Xu, J.; Wang, H. Inhibition of Phosphodiesterase-4 Suppresses HMGB1/RAGE Signaling Pathway and NLRP3 Inflammasome Activation in Mice Exposed to Chronic Unpredictable Mild Stress. Brain Behav Immun 2021, 92, 67–77. https://doi.org/10.1016/j.bbi.2020.11.029.

43. Huang, P.; Wei, S.; Luo, M.; Tang, Z.; Lin, Q.; Wang, X.; Luo, M.; He, Y.; Wang, C.; Wei, D.; Xia, C.; Xu, J. MiR-139-5p Has an Antidepressant-like Effect by Targeting Phosphodiesterase 4D to Activate the cAMP/PKA/CREB Signaling Pathway. Ann Transl Med 2021, 9 (20), 1594. https://doi.org/10.21037/atm-21-5149.

44. Xu, B.; Xu, J.; Cai, N.; Li, M.; Liu, L.; Qin, Y.; Li, X.; Wang, H. Roflumilast Prevents Ischemic Stroke-Induced Neuronal Damage by Restricting GSK3β-Mediated Oxidative Stress and IRE1α/TRAF2/JNK Pathway. Free Radic Biol Med 2021, 163, 281–296. https://doi.org/10.1016/j.freeradbiomed.2020.12.018.

45. Dong, W.-L.; Zhong, J.-H.; Chen, Y.-Q.; Xie, J.-F.; Qin, Y.-Y.; Xu, J.-P.; Cai, N.-B.; Li, M.-F.; Liu, L.; Wang, H.-T. Roflupram Protects against Rotenone-Induced Neurotoxicity and Facilitates α-Synuclein Degradation in Parkinson’s Disease Models. Acta Pharmacol Sin 2021, 42 (12), 1991–2003. https://doi.org/10.1038/s41401-021-00768-4.

46. Li, D.; Xu, J.; Qin, Y.; Cai, N.; Cheng, Y.; Wang, H. Roflupram, a Novel Phosphodiesterase 4 Inhibitor, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Activation of the AMPK/Sirt1 Pathway. Int Immunopharmacol 2021, 90, 107176. https://doi.org/10.1016/j.intimp.2020.107176.