教师信息
一、基本信息
姓名：石蓉懿
职称：副研究员，硕士生导师
联系邮箱：shirongyi@zju.edu.cn
联系电话：
二、学习经历
2011.9-2015.7 四川农业大学，园艺专业，学士
2015.9-2020.7 浙江大学，生物物理学专业，博士
三、承担教学任务
暂无
四、主要研究方向
白血病与肿瘤免疫
主持的基金项目/课题:
(1) 国家自然科学基金委员会青年项目，82200185, 免疫原性化疗趋化CXCR6+ 干细胞样CD8+ T细胞在AML治疗中的作用及机制研究, 2023-01-01 至 2025-12-31，30万元，在研，主持
(2) 中国博士后科学基金会，博士后面上二等项目，2021M692110，骨髓血管微环境调控干细胞样CD8+ T细胞在白血病免疫原性化疗中的机制研究，2021-06-09至 2024-6-28，8万元，结题，主持
五、主要学术任职
暂无
六、培养学生情况
暂无
七、主要获奖情况
博士期间获得国家奖学金，被评为浙江大学优秀毕业生。博士期间多次被评为优秀研究生。博士期间参加浙江大学农学院学术节获得口头报告二等奖，墙报展示一等奖。博士后期间获得国家自然科学基金青年项目、上海交通大学医学院博士后激励计划资助以及上海儿童医学中心国家自然科学基培育项目资助。
代表性论文 （请按表格格式填写）
1. Shi, R. Y.#, Zhou, N.#, Xuan, L. #, Jiang, Z. H. #, Xia, J., Zhu, J. M., Chen, K. M., Zhou, G. L., Yu, G. P., Zhang, J., Huang, C., Liang, A. B., Liang, K. W., Zhang, H., Chen, J. F., Zhang, D., Zhong, Y.*, Liu, Q. F.*, Chen, G. Q.*, Duan, C. W.*; Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity. Nat Cell Biol, 2024 Aug;26(8):1346-1358.
2. Li, Q. Q.#, Guo, M. #*, He, G. H., Xi, K. H., Zhou, M. Y., Shi, R. Y.*, Chen, G. Q.*; VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane. Oncogene, 2024, 43(24), 1836-1851.
3. Shi, R., Wang, Y., Gao, Y., Xu, X., Mao, S., Xiao, Y., Song, S., Wang, L., Tian, B., Zhao, Y., Hua, Y.*, Xu, H.*; Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability. Am J Physiol Cell Physiol, 2020, 319(4), C657-c666.
4. Xu, H.#, Shi, R.#, Han, W., Cheng, J., Xu, X., Cheng, K., Wang, L., Tian, B., Zheng, L., Shen, B.*, Hua, Y.*, Zhao, Y.*; Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res, 2018, 46(21), 11315-11325.
5. Xu, X.#, Shi, R.#, Zheng, L.#, Guo, Z.#, Wang, L., Zhou, M., Zhao, Y., Tian, B., Truong, K., Chen, Y., Shen, B.*, Hua, Y.*, Xu, H.*; SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress. J Mol Cell Biol, 2018, 10(5), 460-474.
6. Xiao Y, Yin M, Wang Y, Shi R, Mao S, Hua Y*, Xu H.* Post-translational Modifications by Acyl Groups Regulate FEN1's Activities and Play Essential Roles in Cell Proliferation and DNA Repair. Protein Pept Lett. 2023;30(7):597-607.
7. Huang WL#, Abudureheman T#, Xia J, Chu L, Zhou H, Zheng WW, Zhou N, Shi RY, Li MH, Zhu JM, Qing K, Ji C, Liang KW, Guo S*, Yin G*, Duan CW*. CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism. Front Cell Dev Biol. 2021 Mar 4;9:641271.
8. Abudureheman T#, Xia J#, Li MH#, Zhou H, Zheng WW, Zhou N, Shi RY, Zhu JM, Yang LT, Chen L, Zheng L, Xue K, Qing K*, Duan CW*. CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism. Front Oncol. 2021 Apr 6;11:663360.
9. Xu H#, Chen X#, Ying N, Wang M, Xu X, Shi R, Hua Y*. Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells. PLoS One. 2017 Nov 20;12(11):e0186806.
10. Xu H#, Chen X#, Xu X#, Shi R, Suo S, Cheng K, Zheng Z, Wang M, Wang L, Zhao Y, Tian B, Hua Y*. Lysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress. Sci Rep. 2016 Jul 25;6:30212.
