一、基本信息

姓名：许鑫

职称：教授，博士生导师

联系邮箱： xinxu768@smu.edu.cn

二、学习经历

2022.10-2025.12 多伦多大学，玛格丽特公主癌症中心，副研究员

2016.10-2022.10 多伦多大学，玛格丽特公主癌症中心，博士后

2014.7-2016.7 中科院微生物所，微生物资源前期开发国家重点实验室，博士后

2009.9-2014.7 首都师范大学，生化及分子生物学，博士

（2011.12-2012.6 加拿大萨斯卡彻温大学， 访问学者）

2005.9-2009.7 河南师范大学，生物科学，学士

三、主要研究方向

主要从事肿瘤 RNA 转录后调控机制研究，关注非编码RNA和RNA修饰在前列腺癌发生发展中的功能作用，主要包括：

非编码 RNA 及 RNA 转录后调控在肿瘤发生发展过程中的作用及其分子机制；

RNA 修饰在调控 RNA 稳定性、翻译及分子互作中的功能研究；

基于 RNA 转录后调控机制的分子标志物及潜在干预策略探索。

四、代表性论文

1. Xu, X.^#, Zhu, H. ^#, Hugh-White, R. ^#, Livingstone, J. ^#, Eng, S., Zeltser, N., Wang, Y., Pajdzik, K., Chen, S., Houlahan, K.E., et al. (2025). The landscape of N6-methyladenosine in localized primary prostate cancer. Nat Genet 57, 934–948.

2. Teng, M. ^#, Guo, J. ^#, Xu, X. ^#, Ci, X., Mo, Y., Kohen, Y., Ni, Z., Chen, S., Guo, W.Y., Bakht, M., et al. (2025). Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation. Cancer Cell 43, 891-904.e10.

3. Yadav, M., Harding, R.J., Li, T., Xu, X., Gall-Duncan, T., Khan, M., Bardile, C.F., Sequiera, G.L., Duan, S., Chandrasekaran, R., et al. (2024). Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles. Sci Adv 10, eado5264.

4. Lv, D., Dixit, D., Cruz, A.F., Kim, L.J.Y., Duan, L., Xu, X., Wu, Q., Zhong, C., Lu, C., Gersey, Z.C., et al. (2024). Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2. Cell Metabolism 36, 2419-2436.e8.

5. Wei, Z., Wang, S., Xu, Y., Wang, W., Soares, F., Ahmed, M., Su, P., Wang, T., Orouji, E., Xu, X., et al. (2023). MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. Nat Commun 14, 1787.

6. Chen, S. ^#, Huang, V. ^#, Xu, X. ^#, Livingstone, J., Soares, F., Jeon, J., Zeng, Y., Hua, J.T., Petricca, J., Guo, H., et al. (2019). Widespread and functional RNA circularization in localized prostate cancer. Cell 176, 831-843.e22.

7. Fan, Q. ^#, Xu, X. ^#, Zhao, X., Wang, Q., Xiao, W., Guo, Y., and Fu, Y.V. (2018). Rad5 coordinates translesion DNA synthesis pathway by recognizing specific DNA structures in saccharomyces cerevisiae. Curr Genet 64, 889–899.

8. Xu, X. ^#, Lin, A. ^#, Zhou, C. ^#, Blackwell, S.R., Zhang, Y., Wang, Z., Feng, Q., Guan, R., Hanna, M.D., Chen, Z., et al. (2016). Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res 44, 5231–5245.

9. Ball, L.G. ^#, Xu, X. ^#, Blackwell, S., Hanna, M.D., Lambrecht, A.D., and Xiao, W. (2014). The Rad5 helicase activity is dispensable for error-free DNA post-replication repair. DNA Repair 16, 74–83.

10. Qin, Z., Lu, M., Xu, X., Hanna, M., Shiomi, N., and Xiao, W. (2013). DNA-damage tolerance mediated by PCNA•ub fusions in human cells is dependent on Rev1 but not polη. Nucleic Acids Research 41, 7356–7369.

本课题组长期招收生物信息学、遗传学、分子生物学、基因组学等相关方向的研究生、博士后以及特聘研究人员，欢迎对肿瘤 RNA 转录后调控研究感兴趣的同学交流与申请。