一、基本信息

姓名：谢海华

职称：教授、博士生导师

联系邮箱：xiehh2025@smu.edu.cn

二、学习经历

2011.9-2015.6  浙江科技大学，生物工程，学士

2015.9-2018.6  温州医科大学，生物学，硕士

2019.9-2024.12 浙江大学，细胞生物学，博士

三、主要研究方向

1. DNA损伤修复通路的动态调控网络与基因组稳定性维持；

2. 复制压力响应网络与基因组稳定性维持；

3. 肿瘤耐药性产生的分子机制与靶向干预策略。

四、代表性论文

1. Xie, H. H.^#, Song, L. Z.^#, Mao, G. X., Han, J. H., Pu, J. L., Wu, Z. B., Chen, J., Zhou, J. W., Huang, J., Fang, D., and Liu, T. Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2–RAD51, Nature Chemical Biology, 2025.

2. Song, L. Z.^#, Xie, H. H.^#, Fan, H. N.^#, Zhang, Y. J.^#, Cheng, Z. X.^#, Chen, J. L.^#, Guo, Y. Z., Zhang, S. D., Zhou, X. Y., Li, Z. S., Liao, H. X., Han, J. H., Huang, J., Zhou, J. W., Fang, D., and Liu, T. Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A, Molecular Cell, 2025, 85(3): 506-522.

3. Xu, Z. Q.^#, Xie, H. H.^#, Song, L. Z.^#, Huang, Y. H., and Huang, J. BRCA1 and BRCA2 in DNA Damage and Replication Stress Response: Insights into Their Functions, Mechanisms, and Implications for Cancer Treatment, DNA Repair, 2025, 150: 103847.

4. Xie, H. H.^#, Ge, X. L.^#, Yang, F. Y., Wang, B., Li, S., Duan, J. Z., Lv, X. J., Cheng, C. S., Song, Z. M., Liu, C. B., Zhao, J. Z., Zhang, Y., Wu, J. Y., Gao, C. X., Zhang, J. W., and Gu, F. High-fidelity SaCas9 identified by directional screening in human cells, PLOS Biology, 2020, 18(7): e3000747.

5. Xie, H. H., Tang, L. C., He, X. B., Liu, X. X., Zhou, C. C., Liu, J. J., Ge, X. L., Li, J., Liu, C. B., Zhao, J. Z., Qu, J., Song Z. M., and Gu F. SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells, Biotechnology Journal, 2018, 13(4): e1700561.