一、基本信息

姓名：熊符 

职称：教授

联系邮箱：xiongfu@smu.edu.cn

 

二、学习经历

1994.9-1998.7  长江大学，畜牧兽医专业，学士

1998.9-2001.7  华中农业大学，预防兽医学专业，硕士

2004.9-2007.7  中山大学，干细胞与组织工程专业，博士

 

三、拟招收博士后开展的研究方向

1. 神经遗传性疾病的分子发病机制研究；

2. 口腔遗传性疾病的分子发病机制研究；

3. 遗传性疾病的分子诊断及基因治疗。

 

四、主要学术任职

1. 中华医学会医学遗传学分会委员及副秘书长；

2. 中华口腔医学会口腔遗传病与罕见病专业委员会常务委员；

3. 广东省遗传学会常务理事、秘书长；

4. 广东省医学会医学遗传学会副主任委员、基础遗传学组组长；

5. 广东省地中海贫血防治协会分子诊断委员会副主任委员；

6. 广东省产前诊断专家组成员。

 

五、代表性论文

1. Sun SC, Ma D, Li MY, Zhang RX, Huang C, Huang HJ, Xie YZ, Wang ZJ, Liu J, Cai DC, Liu CX, Yang Q, Bao FX, Gong XL, Li JR, Hui Z, Wei XF, Zhong JM, Zhou WJ, Shang X, Zhang C, Liu XG, Tang BS, Xiong F*, Xu XM*. Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease. Brain. 2019 Jun 14. （共同通讯作者）

2. Pan Y, Lu T, Peng L, Chen Z, Li M, Zhang K, Xiong F*, Wu B*. Vacuolar protein sorting 4B regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells through the Wnt-β-catenin signalling pathway. Artif Cells Nanomed Biotechnol. 2019 Dec; 47(1):2575-2584.（共同通讯作者）

3. Lu T, Li M, Xu X, Xiong J, Huang C, Zhang X, Hu A, Peng L, Cai D, Zhang L, Wu B, Xiong F*. Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders. Int J Oral Sci. 2018; 10(3):26.

4. Miao Y, Xiong J, Zhang X, Huang H, Yu L, Chen J, Deng W, Xu H, Liu R, Xiang C, Xu X, Xiong F*. Genetic diagnosis of polycystic kidney disease, Alport syndrome and thalassemia minor in a large Chinese family. Clin Sci (Lond). 2017; 131(19):2427-2438.

5. Xiong F, Ji Z, Liu Y, Zhang Y, Hu L, Yang Q, Qiu Q, Zhao L, Chen D, Tian Z, Shang X, Zhang L, Wei X, Liu C, Yu Q, Zhang M, Cheng J, Xiong J, Li D, Wu X, Yuan H, Zhang W, Xu X*. Mutation in SSUH2 Causes Autosomal Dominant Dentin Dysplasia Type I. Hum Mutat. 2017; 38(1):95-104.

6. Yang Q, Chen D, Xiong F*, Chen D, Liu C, Liu Y, Yu Q, Xiong J, Liu J, Li K, Zhao L, Ye Y, Zhou H, Hu L, Tian Z, Shang X, Zhang L, Wei X, Zhou W, Li D, Zhang W, Xu X*. A splicing mutation in VPS4B causes dentin dysplasia I. J Med Genet. 2016;53(9):624-33.（共同通讯作者以及共同第一作者）

7. Xiong F, Huang Q, Chen X, Zhou Y, Zhang X, Cai R, Chen Y, Xie J, Feng S, Wei X, Xiao Q, Zhang T, Luo S, Yang X, Hao Y, Qu Y, Li Q, Xu X.A Melting Curve Analysis-Based PCR Assay for One-Step Genotyping of β-Thalassemia Mutations A Multicenter Validation. J Mol Diagn. 2011 Jul; 13(4):427-35.

8. Xiong F, Sun M, Zhang X, Cai R, Zhou Y, Lou J, Zeng L, Sun Q, Xiao Q, Shang X, Wei X, Zhang T, Chen P, Xu X*. Molecular epidemiological survey of haemoglobinopathies in the Guangxi Zhuang Autonomous Region of southern China. Clin Genet. 2010: 78(2): 139–148.

9. Zhu S*, Xiong F*, Chen YJ, Yan TZ, Zeng J, Li L, Zhang YN, Chen WQ, Bao XH, Zhang C, Xu XM*. Molecular characterization of SMN copy number derived from carrier screening and from core families with SMA in a Chinese population.Eur J Hum Genet. 2010, 18(9): 978-84. （共同第一作者）.

10. Xiong F, Xiao S, Peng F, Zheng H, Yu M, Ruan Y, Li W, Shang Y, Zhao C, Zhou W, Chen H, Chamberlain JS, Fang L, Zhang C*. Herpes simplex virus VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice. Hum Gene Ther. 2007; 18(6):490-501.