姓名：周春
职称：副教授，硕士生导师
联系邮箱：zhouch@smu.edu.cn
学习经历：
2010.09—2015.07 中山大学，药学院 药理学 理学博士
2006.09—2010.06 中国药科大学，生命科学与技术学院， 生物技术， 理学学士
工作经历：
2016.01-至今 南方医科大学，药学院，药理学，副教授
研究方向：
1. 类风湿关节炎等炎症相关疾病
2. 破骨细胞分化与骨吸收功能机制研究
学术任职：
1. 世界中医药学会联合会中医药免疫专业委员会 常务理事
2. 澳门风湿病研究国际合作联盟 理事
3. 中国中药学会骨伤科药物研究专委会 委员
4. 获邀担任SCI杂志J NAT PROD，Phytomedicine, Peer J等审稿人。
主持科研项目：
1. 广州市科技计划项目，201804010009，ATP5B介导的线粒体膜稳定性在破骨细胞分化、极化与骨吸收功能中的作用及其机制研究，2018.04-2021.03，20万元，在研，主持；
2. 横向项目，A5药丸补肾抗疲劳作用及其机制研究，18万元，2020.08.1-2021.07.31，在研，主持；
3. 国家自然科学基金青年项目，81601926，Myo6介导的囊泡转运与封闭区形成在破骨细胞分化与骨质侵蚀中的作用及其机制研究，2017.01-2019.12，18万元，结题，主持；
4. 南方医科大学高层次人才引进项目，SNX10在MMP9转运与分泌中的作用研究，20万元，主持，已结题。
5. 国家自然科学基金面上项目，81774358，外泌体miRNA介导蜕膜细胞自噬在自然流产中的作用机制及补肾安胎中药的干预研究，2018.01-2021.12，57万元，在研，合作申请。
代表性论文：
1. Liu K, Liu Y, Xu Y, Nandakumar KS, Tan H, He C, Dang W, Lin J,Zhou C*. Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesis.Phytomedicine. 2019 Jul 2;63:153006. (IF:4.268)
2. Liu KF, Liu Y, Xu YT, Nandakumar KS, Shen XY, Lin JH, Li CX, He CH,Zhou C*. Regulatory role of Golgi brefeldin A resistance factor-1 in amyloid precursor protein trafficking, cleavage and Aβ formation.J Cell Biochem.2019 Sep;120(9):15604-15615.. (IF: 4.237)
3. Dang WZ, Li H, Jiang B, Nandakumar KS, Liu KF, Liu LX, Yu XC, Tan HJ,Zhou C*. Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2-STAT3 signaling pathway.Phytomedicine. 2019 May 19;62:152965. (IF: 4.268)
4. Xie Y, Hu D, Zhong C, Liu KF, Fang E, Zhang YJ,Zhou C*, Tian LW*，Anti-inflammatory furostanol saponins from the rhizomes of Smilax china L.Steroids. 2018 Dec;140:70-76. (IF:2.523)
5. Gao F#,Zhou C#, Qiu W, Wu H, Li J, Peng J, Qiu M, Liang C, Gao J, Luo S. Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways.Sci Rep. 2018 Nov 26;8(1):17342. (IF:4.122)
6.Zhou C, Wang Y, Peng J, Li C, Liu P, Shen X. SNX10 Plays a Critical Role in MMP9 Secretion via JNK-p38-ERK Signaling Pathway.J Cell Biochem. 2017 Dec;118(12):4664-4671. (IF: 4.237)
7. Gao J#,Zhou C#, Li Y, Gao F, Wu H, Yang L, Qiu W, Zhu L, Du X, Lin W, Huang D, Liu H, Liang C, Luo S. Asperosaponin VI promotes progesterone receptor expression in decidual cells via the notch signaling pathway.Fitoterapia. 2016 Sep;113:58-63. (IF:2.642)
8.Zhou C, You Y, Shen WX, Zhu YZ, Peng J, Feng HT, Wang Y, Li D, Shao WW, Li CX, Li WZ, Xu JK, Shen XY. Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation.Ann Rheum Dis. 2016 Jun;75(6):1211-8. (IF:16.102)
9.Zhou C, Li C, Li D, Wang Y, Shao W, et al. (2013) BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways.Neuroscience254: 361-368. (IF:3.357)
10. You Y,Zhou C, Li D, Cao ZL, Shen W, Li WZ, Zhang S, Hu B, Shen X. Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis.Sci Rep. 2016 Feb 9;6:20630. (IF:4.122)
11. Wang Y,Zhou C, Gao H, Li C, Li D, Liu P, Huang M, Shen X, Liu L. Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.Biochem Pharmacol. 2017 Aug 15;138:119-129. (IF:4.96)
12. Zhang XW#,Zhou C#, Zhu HD, Shao W, You Y, et al. (2014) Inhibition of osteoclastogenesis by 6-[10'(Z)-heptadecenyl] salicylic acid from Syzygium tetragonum Wall via preventing nuclear translocation of NFATc1.Phytomedicine21: 960-965. (co-first author, IF: 4.268)
13. Lin S,Zhou C, Neufeld E, Wang YH, Xu SW, et al. (2013) BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function.Arterioscler Thromb Vasc Biol33: e31-38. (IF:6.0)
14. Li C,Zhou C, Wang S, Feng Y, Lin W, et al. (2011) Sensitization of glioma cells to tamoxifen-induced apoptosis by Pl3-kinase inhibitor through the GSK-3beta/beta-catenin signaling pathway.PLoS One6: e27053. (IF:3.234)
15. Li C, Chen S, Yu Y,Zhou C, Wang Y, et al. (2013) BIG1, a Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor, Is Required for GABA-Gated Cl Influx Through Regulation of GABA Receptor Trafficking.Mol Neurobiol. (IF:5.137)
