姓名：白文举

职称：教授，博士生导师

邮箱：baiwj1101@smu.edu.cn

主要招生方向：药物化学、工业药学

个人简介

研究蛋白与小分子的相互作用，专注于合成生物学与药物化学方向。曾就职于全球前十大制药企业Amgen（安进）和AbbVie（艾伯维）公司，拥有六年小分子新药研发经验，负责或参与了多个课题，1个课题进入到临床前研究阶段。以通讯作者或第一作者在Nature Synthesis, JACS, Angew. Chem., J. Med. Chem., ACS Catal., Acc. Chem. Res., Nat. Prod. Rep.等国际权威杂志发表论文19篇；相关研究成果获得美国化学会C&EN采访与报道，Science杂志博客评述。

学习经历

2010-2015：加州大学，圣巴巴拉分校，化学，博士

2006-2009：南开大学，元素所，化学，硕士

2002-2006：南开大学，化学/法学，双学士

工作经历

2024.06-至今：南方医科大学，药学院，教授

2021-2024：AbbVie（艾伯维）公司，药物化学部门，资深研究员

2018- 2021：Amgen（安进）公司，药物化学部门，研究员

2015-2018：斯坦福大学，化学学院，博士后

研究方向

合成生物学、药物化学

科研基金项目

南方医科大学高层次人才引进科研启动项目，2024–2027，主持。

代表性论文

(#为共同第一作者，*为通讯作者）

1. Ma, Q.#; Shan, W.#; Chu, X.#; Xu, H.#; Chen, Z.; Li, F.; Liao, J.-L.*; He C.*; Bai, W.-J.*; Wang, X.* Biocatalytic Enantioselective gamma-C–H Lactonization of Aliphatic Carboxylic Acids. Nature Synthesis 2024, 3, 123.

2. Rago, A. J.; Zoi, I.; Gartman, J. A.; McDaniel, K. A.; Jana, N.; Liu, D.; Bai, W.-J.* Mining Medicinally Relevant Bioreduction Substrates Inspired by Ligand-Based Drug Design. J. Med. Chem. 2024, 67, 13174.

3. Zhang, K.#; Yu, A.#; Chu, X.#; Li, F.; Liu, J.; Liu, L.; Bai, W.-J.*; He C.*; Wang, X.* Biocatalytic Enantioselective β-Hydroxylation of Unactivated C–H Bonds in Aliphatic Carboxylic Acids. Angew. Chem. Int. Ed. 2022, 61, e202204290.

4. Chen, H.#; Huang, M.#; Yan, W.#; Bai, W.-J.*; Wang, X.* Enzymatic Regio- and Enantioselective C–H Oxyfunctionalization of Fatty Acids. ACS Catal. 2021, 11, 10625.

5. Wei, Y.#; Lu, C.#; Jiang, S.; Zhang Y.; Li, Q.; Bai, W.-J.*; Wang, X.* Directed Evolution of a Tryptophan 2,3-Dioxygenase for the Diastereoselective Monooxygenation of Tryptophans. Angew. Chem. Int. Ed. 2020, 59, 3043.

6. Lu, C.#; Shen, F.#; Wang, S.; Wang, Y.; Liu, J.; Bai, W.-J.*; Wang, X.* An Engineered Self-sufficient Biocatalyst Enables Scalable Production of Linear Alpha Olefins. ACS. Catal. 2018, 8, 5794.

7. Trost, B. M. (导师)*; Bai, W.-J.; Stivala, C. E.; Hohn, C.; Poock, C.; Heinrich, M.; Xu, S. Rey, J. Enantioselective Synthesis of des-Epoxy-Amphidinolide N. J. Am. Chem. Soc. 2018, 140, 17316.

8. Trost, B. M. (导师)*; Bai, W.-J.#; Hohn, C.#; Bai, Y.; Cregg, J. J. Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted-1H-Indoles and Tryptophan Derivatives. J. Am. Chem. Soc. 2018, 140, 6710.

9. Bai, W.-J.*; Wang, X.* Appreciation of Symmetry in Natural Product Synthesis. Nat. Prod. Rep. 2017, 34, 1345.

10. Bai, W.-J.; David, J. G.; Feng, Z.-G.; Weaver, M. G.; Wu, K.-L.; Pettus, T.R.R.* The Domestication of ortho-Quinone Methides. Acc. Chem. Res. 2014, 47, 3655.

11. Bai, W.-J.; Xie, J.-H.; Li, Y.-L.; Liu, S.; Zhou, Q.-L.* Enantioselective Synthesis of Chiral β-Aryloxyalcohols by Ruthenium-Catalyzed Ketone Hydrogenation via Dynamic Kinetic Resolution (DKR). Adv. Syn. Catal. 2010, 352, 81.