姓名：毕惠嫦

职称：教授，博士生导师

联系邮箱：bihchang@smu.edu.cn

联系电话：020-61648530

国家杰青/优青获得者；南方医科大学药学院教授、博导、院长，广东省新药筛选重点实验室主任。专注于内/外源物代谢调控对疾病及合理用药影响的研究。主持国家各级课题近20项。已发表中英科研论文130多篇，其中SCI科研论文100多篇，以通讯作者或第一作者在Hepatology（2篇）, Cell Death & Differentiation, British Journal of Pharmacology等发表SCI论文70多篇。主编并出版专著5部，参编7部。

目前担任中国药理学会临床药理学专业委员会副主任委员、中国药理学会分析药理学专业委员会副主任委员、中国药理学会药物代谢专业委员会副主任委员；广东省药理学会药物代谢专业委员会主任委员；广东省药理学会候任理事长等学术兼职。担任5本SCI期刊编委。

获2014年中国药理学会-Servier优秀药理学者奖、2015年国家自然科学优秀青年基金、2018年国际代谢学会（ISSX）亚太青年学者奖（2018 ISSX Asia Pacific New Investigator Award）、2020年国家自然科学杰出青年基金、2021年美国药理与实验治疗学会（ASPET）Richard Okita Early Career Award in Drug Metabolism and Disposition。

 

学习经历

1993.09 - 1997. 06：中国药科大学，获英语药学学士学位

2002.09 – 2007.06：中山大学药学院，获药理学博士学位

工作经历

2022 - 至今： 南方医科大学药学院，教授/博导/院长

2016 - 2021： 中山大学药学院，教授/博导/副院长

2010.06 - 2015.12： 中山大学药学院，副教授

2007.07 - 2010.05： 中山大学药学院，讲师

2018.07 - 2021.06： 美国匹兹堡大学药学院，兼职教授

2015.11 - 2018.06： 美国匹兹堡大学药学院，兼职副教授

2011.10 - 2012.11： 美国国立卫生研究院（NIH），访问学者（博士后）

研究方向

代谢调控与疾病及临床合理用药研究

 

近年主持科研项目

1. 国家自然科学基金杰出青年基金，2021.01～2025.12。

2. 国家自然科学基金（面上项目），2020.01～2023.12。

3. 国家重点研发计划国际合作重点专项，2018.07～2022.06。

4. 国家自然科学基金优秀青年基金，2016.01～2018.12。

5. 国家自然科学基金（面上项目），2016.01～2019.12。

6. 国家自然科学基金（面上项目），2014.01～2017.12。

代表性论文

1.Fan Shicheng#, Gao Yue#, Qu Aijuan, Jiang Yiming, Li Hua, Xie Guomin, Yao Xinpeng, Yang Xiao, Zhu Shuguang, Yagai Tomoki, Tian Jianing, Wang Ruimin, Gonzalez Frank J., Huang Min, Bi Huichang*. YAP-TEAD mediates peroxisome proliferator-activated receptor α-induced hepatomegaly and liver regeneration in mice. Hepatology. 2021 Aug 13 online.

2.Gao Yue, Fan Shicheng, Li Hua, Jiang Yiming, Yao Xinpeng, Zhu Shuguang, Yang Xiao, Wang Ruimin, Tian Jianing, Gonzalez Frank J, Huang Min*, Bi Huichang*. Constitutive androstane receptor induced-hepatomegaly is partially via yes-associated protein activation. Acta Pharm Sin B. 2021; 11(3):727-737.

3.Fu Kaili#, Chen Pan#, Zhou Yanying, Jiang Yiming, Gao Yue, Zhang Huizhen, Guan Lihuan, Wang Conghui, Liu Junling, Huang Min*, Bi Huichang*. Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice. Acta Pharm Sin. 2021. doi: 10.1038/s41401-021-00723-3.

4.Zhao Yingyuan#, Yao Xinpeng, Jiao Tingying, Tian Jianing, Gao Yue, Fan Shicheng, Chen Panpan, Jiang Yiming, Zhou Yanying, Chen Yixin, Yang Xiao, Huang Min, Bi Huichang*. Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice. Phytomedicine. 2021; 84:153520.

5.Zhang Huizhen#, Wang Yongtao, Guan Lihuan, Chen Yixin, Chen Panpan, Sun Jiahong, Gonzalez Frank J., Huang Min, Bi Huichang*. Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence. J Pharm Anal. 2021; 11:340-350.

6.Yao Xinpeng, Jiao Tingying, Jiang Yiming, Fan Shicheng, Zhao Yingyuan, Yang Xiao, Gao Yue, Li Fei, Zhou Yanying, Chen Panpan, Huang Min, Bi Huichang*. PXR mediates mifepristone-induced hepatomegaly in mice. Acta Pharmacol Sin. 2021. doi: 10.1038/s41401-021-00633-4.

7.Huang Wen#, Zhou Jin#, Guo Juanjuan#, Hu Wen, Chen Guanghui, Li Bin, Wen Yajie, Jiang Yimin, Fu Kaili, Bi Huichang*, Zhang Yuanzhen*, Wang Hui*. Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters. BMC Med. 2021; 19:87.

8.Huang Dong#, Wang Ruimin#, Li Wei, Zhao Yingyuan, Yuan Fangyu, Yan Xuelong, Chen Ye, Tang Guihua, Bi Huichang*, Yin Sheng*. Lathyrane Diterpenoids as Novel hPXR Agonists: Isolation, Structural Modification, and Structure-Activity Relationships. ACS Med Chem Lett. 2021; 12(7):1159-1165.

9.Chen Panpan, Zhang Qianbin, Zhang Huizhen, Gao Yue, Zhou Yanying, Chen Yixin, Guan Lihuan, Jiao Tingying, Zhao Yingyuan, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function. J Cell Physiol. 2021; 236(2):958-970.

10.Zhou Yanying#, Fan Xiaomei#, Jiao Tingying, Li Wenzhou, Chen Panpan, Jiang Yiming, Sun Jiahong, Chen Yixin, Chen Pan, Guan Lihuan, Wen Yajie, Huang Min, Bi Huichang*. SIRT6 as a key event linking p53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. Acta Pharm Sin B. 2021; 11(1):89-99.

11.Chen Yixin, Zhou Yanying, Han Fangwei, Zhao Yingyuan, Tu Meijuan, Wang Yongtao, Huang Can, Fan Shicheng, Chen Panpan, Yao Xinpeng, Guang Lihuan, Yu Ai-ming, Gonzalez J Frank, Huang Min, Bi Huichang*. A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 2020; 10(16): 7193-7210.

12.Jiao Tingying#, Yao Xinpeng#, Zhao Yingyuan, Zhou Yanying, Gao Yue, Fan Shicheng, Chen Panpan, Li Xuan, Jiang Yiming, Yang Xiao, Gonzalez Frank J, Huang Min, Bi Huichang*. Dexamethasone-induced liver enlargement is related to PXR/YAP activation and lipid accumulation but not hepatocyte proliferation. Drug Metab Dispos. 2020; 48(9): 830-839.

13.Wang Yongtao#, Yu Tao#, Zhou Yanying, Wang Shike, Zhou Xunian, Wang Limin, Ou Tianmiao, Chen Yixin, Zhou Yawen, Zhang Huizhen, Wang Ying, Fan Xiaomei, Chen Pan, Gonzalez J Frank, Yu Aiming, Huang Peng, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging. 2020; 12(8): 6733-6755.

14.Li Yuhua#, Meng Qiang#, Yang Mengbi#, Liu Dongyang#, Hou Xiangyu#, Tang Lan#, Wang Xin#, Lyu Yuanfeng, Chen Xiaoyan*, Liu Kexin*, Yu Ai-Ming*, Zuo Zhong*, Bi Huichang*. Current trends in drug metabolism and pharmacokinetics. Acta Pharm Sin B. 2019; 9(6): 1113-1144.

15.Guan Lihuan, Chen Yixin, Wang Yongtao, Zhang Huizheng, Fan Shicheng, Gao Yue, Jiao Tingyin, Fu Kaili, Sun Jiahong, Yu Aiming, Huang Min, Bi Huichang*. Effects of carnitine palmitoyltransferases on cancer cellular senescence. J Cell Physiol. 2019; 234(2):1707-1719.

16.Jiang Yiming, Feng Dechun, Ma Xiaochao, Fan Shicheng, Gao Yue, Fu Kaili, Wang Ying, Sun Jiahong, Yao Xinpeng, Liu Conghui, Zhang Huizhen, Xu Leqian, Liu Aiming, Gonzalez J Frank, Yang Yingzi, Gao Bin, Huang Min, Bi Huichang*. Pregnane X receptor regulates liver size and liver cell fate via yes-associated protein activation. Hepatology, 2019; 69(1):343-358.

17.Wang Yongtao, Chen Yixin, Guan Lihuan, Zhang Huizheng, Huang Yaoyao, Johnson H Caroline, Wu Zeming, Gonzalez J Frank, Yu Aiming, Huang Peng, Wang Ying, Yang Shouhui, Chen Pan, Fan Xiaomei, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death Differ. 2018; 25(4):733-746.

18.Sun Jiahong#, Wen Yajie#, Zhou Yanying#, Jiang Yiming, Chen Yixin, Zhang Huizheng, Guan Lihuan, Yao Xinpeng, Huang Min*, Bi Huichang*. P53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression. Cell Death Dis. 2018; 9(5): 536-547.

19.Chen Pan#, Li Dongshun#, Chen Yixin#, Sun Jiahong, Fu Kaili, Guan Lihuan, Zhang Huizhen, Jiang Yiming, Li Xi, Zeng Xuezhen, Chen Xiao, Huang Min, Bi Huichang*. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. Br J Pharmacol. 2017; 174(23):4345-4361.

20.Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M, Bi Huichang*. Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta Pharm Sin B. 2017; 7(5):583-592.

21.Chen Yixin, Wang Yongtao, Huang Yaoyao, Zeng Hang, Hu Bingfang, Guan Lihuan, Zhang Huizhen, Yu Aiming, Johnson H Caroline, Gonzalez J Frank, Huang Min, Bi Huichang*. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis. 2017; 38(4):474-483.

22.Zeng Hang#, Jiang Yiming#, Chen Pan, Fan Xiaomei, Li Dongshu, Liu Aiming, Ma Xiaochao, Xie Wen, Liu Peiqing, Gonzalez Frank J, Huang Min, Bi Huichang*. Schisandrol B protects against cholestatic liver injury through pregnane X receptor. Br J Pharmacol. 2017; 174(8):672-688.