姓名：肖计生
单位：珠江医院
职称：教授，博士生导师、广东省“特支计划”青年拔尖人才
联系邮箱：jsx03@163.com
主要招生方向：药剂学、工业药学
个人简介
中国药科大学药学专业本科，中科院上海药物研究所药剂学博士，美国西北大学生物医学工程系博士后，广州中医药大学杏林青年学者。多年来一直从事药物递送技术促进糖尿病足愈合等组织修复的研究工作。在国际专业期刊上以第一作者（含共一）或通讯作者（含共通）发表论文二十余篇。包括：Advanced Materials（IF：29.4）、Angewandte Chemie-International Edition（IF: 16.6）、Advanced Functional Materials（IF: 19）、ACS Nano（IF: 17.1）、Nano Today（13.2）、Biomaterials（IF: 14）、Journal of Controlled Release（IF: 10.5）等。入选ESI高被引论文2篇。获得5项中国国家发明专利授权，申请PCT专利1项。主持国家自然科学基金项目面上项目2项，青年项目1项；主持广东省卫健委“特支计划”青年拔尖人才项目1项，广东省自然科学基金面上项目1项。
教育与工作经历
2021.10 ~ 至今, 南方医科大学珠江医院转化医学研究中心 教授、博导。
2018.4 ~ 2021.9, 广州中医药大学 研究员、博导。
2014.2 ~ 2017.10, 美国西北大学 博士后（合作导师：Guillermo Ameer 教授）。
2008.9 ~ 2013.7, 中国科学院上海药物研究所药剂学专业理学博士（导师：李亚平 研究员）。
2003.9 ~ 2007.7, 中国药科大学药学专业理学学士。
科研项目
“广东特支计划”省卫生健康委（卫生健康人才）项目，0720240217，主持2024.10-2027.9
广东省自然科学基金面上项目，2024A1515012721，主持2024.1-2026.12
国家自然科学基金面上项目，82272153，主持，2023.1-2026.12
国家自然科学基金面上项目，31971321，主持，2020.1-2023.12
国家自然科学基金青年项目，81801815，，主持，2019.1-2021.12
American Heart Association (AHA) postdoctoral fellowship，主持，2016.1-2017.10
研究方向：
（1）糖尿病足伤口敷料的设计、构建、评价与机制研究
（2）皮肤防护剂的的研发
研究内容涉及：
生物材料的设计、合成与表征；伤口敷料的构建与评价；药物剂型（纳米颗粒、凝胶等）的制备与表征；细胞与动物实验；纳米毒理/安全性评价；分子机制的研究。
发表论文
2024年
1. Peishan Li, Jiaxin Li, Jinmei Cheng, Junyi Huang, Jinhui Li, Jisheng Xiao*, Xiaopin Duan*, Hypoxia-responsive liposome enhances intracellular delivery of photosensitizer for effective photodynamic therapy. Journal of Controlled Release, 2024, 377:277-287. IF: 10.5
2. Qianyi Su, Zhenyu Wang, Huimin Zhou, Miaomiao Zhang, Wenjia Deng, Xin Wei, Jisheng Xiao*, Xiaopin Duan*, Eradication of Large Tumors by Nanoscale Drug Self-assembly, Advanced Materials, 2024, 36(49):e2410536. IF: 27.4
3. Zhenyu Wang, Qianyi Su, Wenjia Deng, Xiao Wang, Huimin Zhou, Miaomiao Zhang, Wenbin Lin, Jisheng Xiao*, and Xiaopin Duan*, Morphology-Mediated Tumor Deep Penetration for Enhanced Near Infrared II Photothermal and Chemotherapy of Colorectal Cancer, ACS Nano, 2024, 18(41):28038-28051. IF: 15.8
4. Qianyi Su, Zhenyu Wang, Peishan Li, Xin Wei, Jisheng Xiao,* and Xiaopin Duan,* pH and ROS Dual-Responsive Autocatalytic Release System Potentiates Immunotherapy of Colorectal Cancer, Advanced Healthcare Materials, 2024, 13(29):e2401126. IF: 10.0
5. Jinmei Cheng,1 Qilin Yu,1 Jiaxin Li,1 Zhiyong Xu, Jinhui Li, Leyang Guan, Jisheng Xiao,* Xiaopin Duan,* Intrinsic tumor-targeted murine Ferritin nanocage co-delivers GPX4 and FSP1 inhibitors for synergistic ferroptosis-immunotherapy, Nano Today, 2024, 58, 102411 IF: 13.2
6. Jinmei Cheng,1 Jiaxin Li,1 Qilin Yu,1 Peishan Li, Junyi Huang, Jinhui Li, Leyang Guan, Zhiyong Xu, Jisheng Xiao* and Xiaopin Duan*, Laser-activable murine ferritin nanocage for chemo-photothermal therapy of colorectal cancer, Journal of Nanobiotechnology, 2024, 22 (297). IF: 10.6
7. Jinmei Cheng,1 Yushun Dou,1 Jiaxin Li,1 Tingting You, Yihai Wang, Mengchuan Wang, Shengjun Shi, Chun-hui Cui, * Xiaopin Duan,* Jisheng Xiao*, A Thermosensitive Hydrogel-Copper Meta-Organic Framework Composite Improves Hindlimb Ischemia Therapy through Synergistically Enhancing HIF-1α Production and Inhibiting HIF-1α Degradation, Materials & Design, 2024, 238, 112638. IF: 8.4
2023年
8. Zhenyu Wang, Tingting You, Qianyi Su, Wenjia Deng, JiaBao Li, Saixiang Hu, Shengjun Shi, Zhaowei Zou*, Jisheng Xiao*, Xiaopin Duan*, Laser-Activatable In Situ Vaccine Enhances Cancer-Immunity Cycle, Advanced Materials, 2023, 10.1002/adma.202307193. IF: 29.4
9. Chengyuan Cai,1 Junqiao Zhu,1 Xiaobin Huang,1 Changda Xu, Zhenyu Wang, Tingting You, Xiao Wang, Jisheng Xiao*, Xiaopin Duan*, Hypoxia-Responsive Nanoscale Coordination Polymer Enhances the Crosstalk between Ferroptosis and Immunotherapy, Advanced Functional Materials, 2023, 10.1002/adfm.202214998. IF: 19
10. Zhenyu Wang, Tingting You, Chengyuan Cai, Qianyi Su, Jinmei Cheng, Jisheng Xiao*, Xiaopin Duan*, Biomimetic Gold Nanostructure with Virus-Like Topological Surface for Enhanced Antigen Cross-Presentation and Antitumor Immune Response. ACS Applied Materials & Interfaces, 2023 15, 11, 13929-13940 IF:9.5
11. Yao Wang, Ran Cao*, Chen Wang, Xiyu Song, Ruina Wang, Jiacun Liu, Mengmeng Zhang, Junyi Huang, Tingting You, Yihua Zhang, Dapeng Yan, Wendong Han*, Lan Yan, Jisheng Xiao*, Peng Li*, In Situ Embedding Hydrogen-Bonded Organic Frameworks Nanocrystals in Electrospinning Nanofibers for Ultrastable Broad-Spectrum Antibacterial Activity, Advanced Functional Materials, 2023, doi.org/10.1002/adfm.202214388. IF: 19
2022年及以前
12. Jisheng Xiao,1,* Haishan Li,1 Wanling Zhao, Jinmei Cheng, Jiaxin Li, Xiaopin Duan,*, Zinc-Metal-Organic Frameworks with Tunable UV Diffuse-reflectance as Sunscreens, Journal of Nanobiotechnology, 2022, 20:87. IF: 10.2
13. Yao Wang,+ Kaikai Ma,*+ Jiaquan Bai, + Tao Xu, Wendong Han, Chen Wang, Zhenxia Chen, Kent O. Kirlikovali, Peng Li, * Jisheng Xiao,* and Omar K. Farha*, Chemically-Engineered Porous Molecular Coatings as Reactive Oxygen Species Generators and Reservoirs for Long-Lasting Self-cleaning Textiles, Angewandte Chemie-International Edition, 2022, 61, e202115956, IF: 16.6
14. Xiaotian Ji, Yousheng Mo, Wanling Zhao, Aiqi Zhong, Xiaoying Su, Sijun Liu, Shengqing Li, Qi Wang,* Xiaopin Duan,* Jisheng Xiao*. Gender-Dependent Reproductive Toxicity of Copper Metal-Organic Frameworks and Attenuation by Surface Modification, Nanoscale, 2021, 13, 7389-7402. IF: 6.7
15. Jisheng Xiao, Yunxiao Zhu, Samantha Huddleston, Peng Li, Baixue Xiao, Omar K. Farha, and Guillermo A. Ameer*. Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes, ACS Nano, 2018;12(2):1023-1032. IF: 17.1
16. Jisheng Xiao, Siyu Cheng, Ji Yi, Hao Zhang, Guillermo Ameer*. A Cooperative Copper Metal–Organic Framework-Hydrogel System Improves Wound Healing in Diabetes, Advanced Functional Materials, 2017, 27(1), doi: 10.1002/adfm.201604872. IF: 19
17. Xiaopin Duan1, Jisheng Xiao1, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*. Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram. ACS Nano 2013, 7 (7), 5858-5869. (共同第一作者) IF: 17.1
18. Jisheng Xiao,1 Xiaopin Duan1, Zhiwen Zhang, Haijun Yu, Lingli Chen, Yaping Li*. Nanodiamonds-Mediated Doxorubicin Nuclear Delivery to Inhibit Lung Metastasis of Breast Cancer, Biomaterials 2013, 34 (37):9648-9656. IF: 14
19. Jisheng Xiao, Xiaopin Duan, Qi Yin, Zehong Miao*, Haijun Yu, Chunying Chen, Zhiwen Zhang*, Jun Wang, Yaping Li*. The Inhibition of Metastasis and Growth of Breast Cancer by Blocking the NF-kB Signaling Pathway Using Bioreducible PEI-based/p65 shRNA Complex Nanoparticles. Biomaterials 2013, 34 (21):5381-5390. IF: 14
20. Jisheng Xiao, Xiaopin Duan, Zhiwen Zhang, Haijun Yu, Yaping Li*. Effective Delivery of p65 shRNA by Optimized Tween 85-Polyethyleneimine Conjugate for Inhibition of Tumor Growth and Lymphatic Metastasis. Acta Biomaterialia 2014, 10 (6):2674-2683. IF: 9.7
21. Jisheng Xiao, Xiaopin Duan, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*. Low Molecular Weight Polyethylenimine-Graft-Tween 85 for Effective Gene Delivery: Synthesis and in vitro Characteristics. Bioconjugate Chemistry 2012, 23 (2):222-231. IF: 4.7
22. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li. Multi-targeted Inhibition of Tumor Growth and Metastasis by Disulfiram-loaded Redox-sensitive Shell Crosslinked Micelles. Nanotechnology 2014, 25:125102. IF: 3.5
23. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Shirui Mao, Yaping Li*. Amphiphilic Graft Copolymer Based on Poly(styrene-co-maleic anhydride) with Low Molecular Weight Polyethylenimine for Efficient Gene Delivery. International Journal of Nanomedicine 2012, 7:4961-4972. IF: 8
24. Zhiwen Zhang, Fang Gao, Huihui Bu, Jisheng Xiao, Yaping Li*. Solid Lipid Nanoparticles Loading Candesartan Cilexetil Enhance Oral Bioavailability: in vitro Characteristics and Absorption Mechanism in Rats. Nanomedicine: Nanotechnology, Biology and Medicine 2012, 8 (5):740-747. IF: 5.4
25. Mengling Wang,1 Feng Zeng,1 Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin*, Xudong Xu*, Xuemei Zhang*. Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis. Journal of Nanobiotechnology, 2022, 20:3. IF: 10.2
已授权发明专利
1.一种能够自组装成胶束的多西他赛聚氧乙烯-聚氧丙烯-聚氧乙烯化合物，专利号：ZL201110170501.0
2.紫杉醇衍生物及其制备方法和用途，专利号：ZL201110122969.2
3.一种用作非病毒基因载体的两亲性梳状SMA-PEI接枝共聚物及其制备方法和用途，专利号：ZL201210102333.6
4.一种铜-大黄蒽醌金属有机框架复合物及其应用，202010357062.3
5.一种锌的金属有机框架ZIF-8及其应用，202010359928.4
获奖及荣誉
中国科学院 “百篇优秀博士论文”（2014）
本课题组招聘博士后、博士、硕士，欢迎对药学、材料合成、分子机制研究（如神经/免疫方向等）感兴趣的同学联系。邮箱：jsx03@163.com。
