张超

教授 ，博士生导师

南方医科大学 基础医学院 实验管理中心 主任 书记

电子邮件: zhangchao1558@126.com

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

张超，教授，博士生导师。曾在加拿大多伦多大学和中国科学院南海海洋研究所从事博士后研究，现兼任中国毒理学会放射医学委员会委员、中国毒理学会青年委员等学术职务。长期从事放射性心脏损伤研究，主持国家级、省市级科研项目多项。以第一作者或通讯作者发表SCI论文二十余篇，其中中科院小类一区TOP论文5篇。

研究方向

放射性心脏损伤的发生机制与精准防护研究

围绕放射性心脏损伤（RIHD），系统开展单细胞多组学解析心脏微环境重塑、放射相关血管损伤与类动脉粥样硬化样改变、circRNA心脏保护机制及靶向递送、以及肿瘤负荷背景下RIHD机制调控与干预策略等研究。

研究关键词

放射性心脏损伤；单细胞多组学；纳米材料递送；肿瘤心脏病学

代表性论著

1.Yixiang HePeng#, Zhi Xu#, Ping Gou, Bosong Zhou, Quan Zheng, Ke Zhu, Xiangfeng Liu, Ruiyuan Liu*, Xu Wu*, Chao Zhang*. Phenylboronic acid modified Ag2S NPs for bacterial targeting photothermal antibacterial therapy and promotion of wound healing. RSC Advances, 2026, 16: 9027–9039. (中科院小类 3区 , IF=4.2)

2.Zhi Xu#, Xiang Xue#, Xiaodong Luo, Surui Yang, Yixiang HePeng, Yile Jin, Chen Zhang, Junjie Xi, Chao Zhang*, Ruiyuan Liu*, Xu Wu*. Injectable, self-healing and wound microenvironment responsive hydrogel for photothermal, chemodynamic, and hydrogen sulfide gas synergistic therapy of the infected diabetic wound healing. International Journal of Biological Macromolecules, 2026, 348: 150849. (中科院小类 2区top , IF=8.5)

3.Zhihan Fang#, Liyao Xie#, Jing Wang#, Junyi Li, Yirui Pan, Lei Chen, Shuyi Cao, Qi Zhou, Shaobin Li*, Chao Zhang*, Li Li*. The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study. Frontiers in Pharmacology, 2025, 16: 1600489. (中科院小类 3区 , IF=4.8)

4.Zhihui Zhang#, Simin Xi#, Chen Lu, Zhi Xu, Lidong Deng, Surui Yang, Lie Li, Xianglin Dong, Ruiyuan Liu, Chao Zhang*, Xu Wu*. NIR laser triggered carbon monoxide, type I photodynamic and photothermal synergistic treatment of bacterial infected wounds. Materials & Design, 2025, 260: 115275. (中科院小类 2区 , IF=7.9)

5.YiWen Zhang#, ShuYi Cao#, FengXia Zeng, DeRun Pan, LongMei Cai, YingYing Zhou, HongMei Wang, GengGeng Qin, Chao Zhang*, WeiGuo Chen*. Dihydroartemisinin enhances the radiosensitivity of breast cancer by targeting ferroptosis signaling pathway through hsa_circ_0001610. European Journal of Pharmacology, 2024, 983: 176943. (中科院小类 3区 , IF=4.8)

6.Xiangyu Wang#, Minkai Song#, Xiaomin Li, Cailin Su, Yanlin Yang, Kai Wang, Cuiting Liu, Zongji Zheng, Yijie Jia, Shijing Ren, Wenhui Dong, Jiaqi Chen, Ting Wang, Lerong Liu, Meiping Guan, Chao Zhang*, Yaoming Xue*, CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease. Am J Physiol Cell Physiol, 2023, Aug 1;325(2) (中科院小类3区，IF=4.7)

7.Minkai Song#, Xiangyu Wang#, Jiawen Gao#, Weizhou Jiang, Enguang Bi, Taixue An, Ting Wang, Zishuo Chen, Weilu Liu, Zhanjun Shi, Jun Xiao*, Chao Zhang*, circIFNGR2 regulating ankylosing spondylitis-associated inflammation through macrophage polarization. iScience. 2023 Jul 10;26(8):107325 (中科院小类2区, IF=4.1)

8.Jia-Wen Gao#, Min-Kai Song#, Di-Zheng Wu#, Tao Yan, Kai Zhao, Yu-Sheng Huang, Xing-Yu Chen, Chen Tu, Guang-Xu Deng, Zi-Shuo Chen, Ming-Ming Zhang, Jun-Long Huang, Chao Zhang*, Zhao-Ming Zhong*, CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p. Clinical Science, 2023, 137(6) (中科院小类2区，IF=7.7)

9.Jing Yuan#, Fei Lin#, Zhiyong Wu#, Zhilin Jiang, Ting Wang, Sitong Huo, Weinan Lai*, Li Li*, Chao Zhang*, Circ-CPSF1 Worsens Radiation-Induced Oxidative Stress Injury in Caenorhabditis elegans. Biomolecules, 2023,13.102.(中科院大类2区，IF=4.8)

10.Hao Shi#, Jiamin Zhao#, Yiwen Li, Junjie Li, Yunjia Li, Jia Zhang, Zhantu Qiu, haofeng Wu, Mengchen Qin, Chang Liu, Zhiyun Zeng, Chao Zhang*, Lei Gao*, Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans. Journal of Ginseng Research, 2022,11(中科院小类1区，IF=5.735)

11.Yining Gao#, Jiawen Gao#, Fei Lin# , Ting Wang, Sitong Huo, Jiefang Wu*, Qi Zhou*, Chao Zhang*. CircRNAs in Tumor Radioresistance. Biomolecules, 2022,12,1586(中科院小类2区，IF=4.8)

12.Minkai Song#, Jiawen Gao#, Tao Yan#, Enguang Bi, Taixue An, Xiangyu Wang , Weizhou Jiang, Ting Wang, Zishuo Chen, Zhanjun Shi, Chao Zhang*, Jun Xiao*. Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis. Frontiers in cell and development cell. 2021, 9:737599（中科院小类2区，IF=6.68）

13.Chao Zhang#, RongFang Ding#, YiCheng Sun#, SiTong Huo, Alina He, Chang Wen, HongHao Chen, William W. Du, WeiNan Lai, Huijun Wang. Circular RNA in tumor metastasis. Molecular Therapy: Nucleic Acids. 2021, 23:(1243-1258) (中科院小类 2区， IF=10.2)

14.Chao Zhang#, Si Tong Huo#, Zhiyong Wu#, Lina Chen, Chang Wen, Honghao Chen, William W. Du, Nan Wu, Daogang Guan, Sen Lian, Burton B. Yang. Rapid Development of Targeting circRNAs in Cardiovascular Diseases. Molecular Therapy: Nucleic Acids. 2020,21:(568-576). (中科院小类 1，TOP. IF=10.2)

15.Chao Zhang, SenjieLin. Initial evidence of functional siRNA machinery in dinoflagellates. Harmful Algae, (2019)81:53-58 (中科院小类1区 TOP, IF=5.9)

16.Yong Xia, Taek Won Kang, Do Young Jung, Chao Zhang∗, Sen Lian∗. Sulforaphane inhibits non-muscle invasive bladder cancer cells proliferation through suppression of HIF-1α-mediated glycolysis in hypoxia. Journal of Agricultural and Food Chemistry, 2019,67(28):7844-7854(中科院小类1区 TOP, IF=5.9)

17.Chao Zhang, Hao Luo, Liangmin Huang, Senjie Lin. Molecular mechanism of glucose-6-phosphate utilization in the dinoflagellate Karenia mikimotoi. Harmful Algae, 67 (2017),74–84 (中科院小类 1区 TOP, IF=5.9)

17.William W Du, Chao Zhang, Weining Yang, Tianqiao Yong, Faryal Mehwish Awan, Burton B Yang. Identifying and Characterizing circ RNA-Protein Interaction. Theranostics, 2017; 7(17): 4183-4191 (中科院小类 1区, IF=11.6).

18.Chao Zhang, Senjie Lin*, Liangmin Huang, Wang Lu, Meizhen Li, Sheng Liu. (2014) Suppression subtraction hybridization analysis revealed regulation of some cell cycle and toxin genes in Alexandrium catenella by phosphate limitation. Harmful Algae:39,26-39. (中科院小类1区 TOP, IF=5.9)

代表性课题

主持: 国家自然科学基金青年项目82473569，项目名称：电离辐射抑制circNCX1促进心肌细胞铁死亡和放射性心脏损伤的作用及机制研究（2025）

主持:国家自然科学基金面上项目: 81872557，项目名称：hsa_circ_0005232在放疗损伤心肌细胞中的作用机制研究（2019）

主持: 国家自然科学基金青年项目:81502761，项目名称：秀丽隐杆线虫FAR基因在放射损伤和修复过程中的作用及分子机制研究（2016）

学术任职

1. 国家医学基础实验教学中心， 副主任（2022）

2. 广东省肝脏病学会肝癌委员会青年委员会 副主任委员（2021）

3. 中国毒理学会放射医学委员会 青年委员（2021）

执教课程（课程及教材建设）

临床本科、临床八年制、临床（卓越创新班）、基础医学（院创班）等专业《生物化学》、《分子生物学》、《分子诊断学》等课程。

荣誉奖励

1. 2017年，广东省生化大赛第一名，优秀指导指导老师

2. 2020年，第十一届南医优秀教师