张琳博士

教授，博士生导师

教研室主任

电子邮件: zlilyzh@smu.edu.cn

电话：020-61648205

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

张琳，医学博士，留美博士后。组织胚胎学教研室主任，二级教授，博士生和博士后联合导师，珠江学者特聘教授。主要从事皮肤的基础与应用研究，运用基因敲除小鼠模型，探讨了皮肤屏障形成、皮肤衰老、皮肤创伤修复、以及皮肤相关疾病过程中信号调控机制；系统阐明了小G蛋白家族在干细胞对皮肤创伤愈合的治疗作用和信号调控机制；并聚焦新型生物材料在皮肤创伤愈合过程中的治疗应用。相关研究为解决皮肤发育调控的信号机制、创伤愈合附属器官再生难题，及构建高质量仿生皮肤提供研究基础和新的治疗思路。

研究方向

皮肤的基础与应用

研究关键词

皮肤发育（skin development ），皮肤衰老（skin aging），皮肤屏障（skin barrier），角质形成细胞（Keratinocyte），创伤修复（Wound healing），信号转导（signaling transduction），干细胞（stem cell）。

代表性论著

1.Huiyi Tang, Xueer Wang, Min Zhang, Yuan Yan, Simin Huang, Jiahao Ji, Jinfu Xu, Yijia Zhang, Yongjie Cai, Bobo Yang, Wenqi Lan, Mianbo Huang*, Lin Zhang*. MicroRNA-200b/c-3p regulate epithellial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling. Cell Death & Disease. 2020;29;11(10):931.

2.Yuan Yan#*, Ruijun Wu#, Yunyao Bo, Min Zhang, Yinghua Chen, Xueer Wang, Mianbo Huang, Baiting Liu, Lin Zhang*. Induced pluripotent stem cells-derived microvesicles accelerate deep second-degree burn wound healing in mice through miR-16-5p-mediated promotion of keratinocytes migration. Theranostics. 2020;10(22):9970-9983. 

3.Genghong Tu, Li Ying, Liuzhen Ye, Jinlan Zhao, Nuyun Liu, Juan Li, Yutong Liu, Mengjuan Zhu, Yue Wu, Bin Xiao, Huidong Guo, Fukun Guo, Huijun Wang, Lin Zhang*, Lu Zhang*. Dopamine D1 and D2 receptors differentially regulate Rac1 and Cdc42 signaling in the nucleus accumbens to modulate behavioral and structural plasticity after repeated methamphetamine treatment. Biological Psychiatry. 2019;86(11):820-835.

4.Yuan Yan^#, Jie Jiang^#, Min Zhang, Yinghua Chen, Xueer Wang, Mianbo Huang, Lin Zhang*. Effect of iPSCs-derived Keratinocytes on Healing of Full-Thickness Skin Wounds in mice. Experimental Cell Research. 2019;385(1):111627.

5.Ruijun Wu,Dan Du,Yunyao Bo,Min Zhang,Lin Zhang,Yuan Yan.Hsp90α promotes the migration of iPSCs-derived keratinocyte to accelerate deep second-degree burn wound healing in mice. Biochem Biophys Res Commun. 2019;520(1):145-151.

6.Chuxi Lin^#, Xueer Wang^#, Qing Peng, Yang Li, Lin Zhang* and Yi Gao*. Characterization and evaluation of HGF-loaded PLGA nanoparticles in a CCl4-induced acute liver injury mouse model. Journal of nanomaterials. 2019:13.

7.Jinlan Zhao^#, Li Ying^#, Yutong Liu, N Liu, Genghong Tu, Mengjuan Zhu, Yue Wu, Bin Xiao, Liuzhen Ye, Juan Li, Fukun Guo, Lin Zhang*, Huijun Wang*, and Lu Zhang*. Different roles of Rac1 in the acquisition and extinction of methamphetamine-associated contextual memory in the nucleus accumbens. Theranostics. 2019;9(23):7051-7071.

8.Min Zhang^#, Xueer Wang^#, Fukun Guo, Qin Jia, Yinghua Chen, Yuan Yan, Mianbo Huang, Huiyi Tang, Simin Huang, Ying Deng, Zhitao Zhou, Lu Zhang*, and Lin Zhang*. Cdc42 deficiency leads to epidermal barrier dysfunction by regulating intercellular junctions and keratinization of epidermal cells during mouse skin development. Theranostics.2019; 9(17): 5065-5084.

9.Jinhua Xue^#, Yutong Liu^#, Mohammad Ali Darabi, Genghong Tu, Lu Huang, Li Ying, Bin Xiao, Yue Wu, Malcolm Xing*, Lin Zhang* and Lu Zhang*. An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment. Materials Science & Engineering C-Materials for Biological Applications. 2019;100: 584-597. 

10.Pei Tang^#, Xueer Wang^#, Min Zhang, Simin Huang, Chuxi Lin, Fang Yan, Ying Deng, Lu Zhang* and Lin Zhang*. Activin B stimulates mouse vibrissae growth and regulates cell proliferation and cell cycle progression of hair matrix cells through ERK signaling. International Journal of Molecular Sciences, 2019;20(4), 853.

11.Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yuan Yan, Mianbo Huang, Yinghua Chen, Lu Zhang* and Lin Zhang*. mDia1 and Cdc42 regulate Activin B-induced migration of bone marrow-derived mesenchymal stromal cells. Stem Cells. 2019;37(1):150-162.

12.Min Zhang#, Xueer Wang#, Fukun Guo, Qin Jia, Nuyun Liu, Yinghua Chen, Yuan Yan, Mianbo Huang, Huiyi Tang, Ying Deng, Simin Huang, Zhitao Zhou, Lu Zhang*, and Lin Zhang*. Cdc42 deficiency leads to epidermal barrier dysfunction by regulating intercellular junctions and keratinization of epidermal cells during mouse skin development. Theranostics.2019; 9(17): 5065-5084. 

13.Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yuan Yan, Mianbo Huang, Yinghua Chen, Lu Zhang* and Lin Zhang*. mDia1 and Cdc42 regulate Activin B-induced migration of bone marrow-derived mesenchymal stromal cells. Stem Cells. 2019;37(1):150-162. 

14.Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang*, Buling Wu*, Lin Zhang*. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018, 1864(8):2623-2632. 

15.Hai-Hong Wang，Yan Li，Ang Li，Fang Yan，Zhen-Lin Li，Zhong-Ying Liu，Lei Zhang，Jian Zhang，Wei-Ren Dong*，Lin Zhang*. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular Neurobiology. 2018;55(1):696-706. 通

16.Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yinghua Chen, Yuan Yan, Zhihui Tian, Pengcheng Xu, Lei Zhang, Lu Zhang*, Lin Zhang*. RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling. BBA-General Subjects. 2017;1861(1 Pt A):3011-3018.

17.Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang*, Buling Wu*, Lin Zhang*. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018, 1864(8):2623-2632.

18.Hai-Hong Wang，Yan Li，Ang Li，Fang Yan，Zhen-Lin Li，Zhong-Ying Liu，Lei Zhang，Jian Zhang，Wei-Ren Dong*，Lin Zhang*. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular Neurobiology. 2018;55(1):696-706. 

19.Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yinghua Chen, Yuan Yan, Zhihui Tian, Pengcheng Xu, Lei Zhang, Lu Zhang*, Lin Zhang*. RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling. BBA-General Subjects. 2017;1861(1 Pt A):3011-3018.

20.Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang*, Buling Wu*, Lin Zhang*. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018;1864(8):2623-2632. 

21.Yutong Liu^#, Juan Li^#, Kaige Xu, Jingjing Gu, Lu Huang, Lei Zhang, N. Liu, Jiming Kong, Malcolm Xing, Lin Zhang, Lu Zhang. Characterization of superparamagnetic iron oxide nanoparticle-induced apoptosis in PC12 cells and mouse hippocampus and striatum. Toxicology Letters. 2018;292:151-161.

22.Lei Zhang^#, Singh Gurankit^#, Min Zhang, Chen Shixuan, Kaige Xu, Pengcheng Xu, Xueer Wang, Yinghua Chen, Lu Zhang*, Lin Zhang*. Bone marrow-derived mesenchymal stem cells laden novel thermo-sensitive hydrogel for the management of severe skin wound healing. Materials Science & Engineering C-Materials for Biological Applications. 2018; 90, 159-167.

23.Pengcheng Xu, Min Zhang, Xueer Wang, Yuan Yan, Yinghua Chen, Wei Wu, Lu Zhang, and Lin Zhang*. Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage. International Journal of Molecular Sciences. 2018;19(4), 953.

24.Yang Yu^#, Xueer Wang^#, Qinglin Li, Min Zhang, Pengcheng Xu, Yinghua Chen, Yuan Yan, Lin Zhang^*. Bioinformatics analysis of gene expression alterations conferring drug resistance in tumor samples from melanoma patients with EGFR‑activating BRAF mutations. Oncology Letters.2018;15(1): 635-641.

25.Hai-Hong Wang，Yan Li，Ang Li，Fang Yan，Zhen-Lin Li，Zhong-Ying Liu，Lei Zhang，Jian Zhang，Wei-Ren Dong*，Lin Zhang*. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular Neurobiology. 2018;55(1):696-706. 

26. Lei Zhang^#, Lu Huang^#, Kangrong Lu^#, Yutong Liu, Genghong Tu, Li Ying, Mengjuan Zhu, Jinlan Zhao, N Liu, Fukun Guo, Lin Zhang*, and Lu Zhang*. Cocaine-induced synaptic structural modification is differentially regulated by D1 and D3 receptors-mediated signaling pathways. Addiction Biology. 2017;22(6):1842-1855. 

27. Xionglin Chen, Min Zhang, Xueer Wang, Yinghua Chen, Yuan Yan，Lu Zhang*, Lin Zhang*. Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angiogenesis and inhibiting inflammation. American Journal of Translational Research. 2017;9(5):2352-2362. 

28. Xionglin Chen^#, Min Zhang^#, Shixuan Chen, Xueer Wang, Zhihui Tian, Yinghua Chen, Pengcheng Xu, Lei Zhang, Lu Zhang*, Lin Zhang*. Peptide-modified Chitosan Hydrogel accelerates skin wound healing by promoting fibroblast proliferation, migration and secretion. Cell Transplantation. 2017;26(8) 1331–1340. 

29. Lei Zhang^#, Pengcheng Xu^#, Xueer Wang, Min Zhang, Yuan Yan, Yinghua Chen, Lu Zhang*, Lin Zhang*. Activin B regulates adipose-derived mesenchymal stem cells to promote skin wound healing via activation of the MAPK signaling pathway. International Journal of Biochemistry and Cell Biology. 2017; 87:69-76.

30. Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yinghua Chen, Yuan Yan, Zhihui Tian, Pengcheng Xu, Lei Zhang, Lu Zhang*, Lin Zhang*. RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling. BBA-General Subjects. 2017;1861(1 Pt A):3011-3018.

31. Juan Li^#, Mohammadali Darabi^#, Jingjing Gu^#, Junbing Shi, Jinhua Xue, Lu Huang, Yutong Liu, Lei Zhang, Wen Zhong, Lin Zhang*, Malcolm Xing*, Lu Zhang*. A drug delivery hydrogel system based on activin B for Parkinson's disease. Biomaterials. 2016;102:72-86.

32. Minhua Wu^#, Xiaoxia Ye^#, Xubin Deng^#, Yanxia Wu, Xiaofang Li, Lin Zhang*. Upregulation of metastasis-associated gene 2 promotes cell proliferation and invasion in nasopharyngeal carcinoma. OncoTargets and therapy. 2016;9:1647-56.

33.Shixuan Chen^#, Junbin Shi^#, Xiaolin Xua, Jianyang Ding, Wen Zhong, Lu Zhang*, Malcolm Xing*, Lin Zhang*. Study of stiffness effects of poly(amidoamine)-poly(n-isopropyl acrylamide) hydrogel on wound healing. Colloids and surfaces B, Biointerfaces. 2016;140:574-82. 

34. Shixuan Chen^#, Min Zhang^#, Xuebing Shao^#, Xueer Wang, Lei Zhang, Pengcheng Xu, Wen Zhong, Lu Zhang *, Malcolm Xing *, Lin Zhang*. A laminin mimetic peptide SIKVAV-conjugated chitosan hydrogel promoting wound healing by enhancing angiogenesis, re-epithelialization and collagen deposition. Journal of Materials Chemistry B. 2015;3:6798-804. 

35.Juan Li, Lei Zhang, Zhenzhong Chen, Minjuan Xie, Lu Huang, Jinhua Xue, Yutong Liu, Nuyun Liu, Fukun Guo, Yi Zheng, Jiming Kong, Lin Zhang*, Lu Zhang*. Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen. Neurobiology of Disease, 2015 75(c):159-176.

36.Juan Li^#, Jingjing Gu^#, Bin Wang^#, Minjuan Xie, Lu Huang, Yutong Liu, Lei Zhang, Jinhua Xue, Fukun Guo, Lin Zhang* and Lu Zhang*. Activation of Dopamine D1 Receptors Regulates Dendritic Morphogenesis Through Rac1 and RhoA in Prefrontal Cortex Neurons. Molecular Neurobiology. 2015;51(3):1024-37. 

37. Wen-Xia Sun^#. Ying-Hua Chen^#. Zhi-Zhong Liu. Jian-Jun Xie. Wei Wang. Ya-Ping Du. Yu Chen. Xu-Liang Shen. Xiao-Feng He*. Li-Xia Wu. Wu Wei*. Lin Zhang*. Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis. Molecular Genetics and Genomics, 2015 Apr;290(2):709-25.

38. Min Zhang^#, Li Sun^#, Xueer Wang, Shixuan Chen, Qin Jia, Nuyun Liu, Yinghua Chen, Yanan Kong, Lu Zhang, and Lin Zhang*. Activin B promotes BM-MSC-mediated cutaneous wound healing by regulating cell migration via the JNK-ERK signaling pathway. Cell Transplantation.2014;23(9):1061-73. 

39. Qin Jia^#, Min Zhang^#, Yanan Kong, Shixuan Chen,Yinghua Chen, Xueer Wang, Lei Zhang,Weiya Lang, Lu Zhang*, Lin Zhang*. Activin B promotes the initiation and development of hair follicles in mice. Cells Tissues Organs, 2013;198(4): 318-326. 

40.. Jingcai Wang, Liang Chen, Chia-I Ko, Lin Zhang*, Alvaro Puga and Ying Xia*. Distinct signaling properties of mitogen-activated protein kinase kinase 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. J Biol Chem. 2012; 287(4): 2787-2797. 

41. Juan Li, Kangrong Lu, Lei Zhang, Jingjing Gu, Fukun Guo, Shengli An, Lin Zhang*, and Lu Zhang*. Cocaine-induced dendritic remodeling occurs in both D1 and D2 dopamine receptor-expressing neurons in the nucleus accumbens. Neuroscience letters. 2012; 517(2): 118-122. 

42. Min Zhang, Xue-Er Wang, Ying-Hua Chen, Qing-Lin Li, Kang-Rong Lu, Li Sun, Qin Jia, Lu Zhang, Lin Zhang*.Activin B promotes epithelial wound healing in vivo through RhoA-JNK signaling pathway. PLoS One. 2011; 6(9): e25143. 

代表性课题

1.2021/01-2024/12，国家自然科学基金面上项目，主持，在研

2.2019/01-2022/12，国家自然科学基金面上项目，在研，主持。

3.2015/01-2020/01，广东省自然科学基金团队项目，已结题，分题负责，排名第二。

4.2014/01-2017/12国家自然科学基金面上项目，已结题，主持。

5.2012/01-2015/12，国家自然科学基金面上项目，已结题，主持。

6.2010/01-2012/12，国家自然科学基金面上项目，已结题，主持。

7.2008/10-2012/10，教育部“新世纪优秀人才” 支持计划，已结题，主持。

8.2012/01-2013/12，2011省高校人才引进专项资金，已结题，主持。

9.2010/01-2012/12，广东省科技计划专项，已结题，主持。

10.高等学校博士学科点专项科研基金，2014/01-2016/12， 12万元，已结题，主持。

学术任职

1.2016.11-至今，广东省解剖学会，副理事长

2.2009.09-至今，中国解剖学会医学发育生物学分会，副主任委员

3.2008.07-至今，中国解剖学会青年组织学与胚胎学专业委员会，常务理事

4.2007.09-至今，中国解剖学会组织学与胚胎学分会，理事

5.2018.12-至今，中国解剖学会人类发育与衰老转化研究联盟，理事

6.2009.12-至今，广东省人体生物组织工程学会，理事

7.2015.10-至今，广东省转化医学学会，理事

8.广东省科协医药学会联合体专家委员会专家

执教课程（课程及教材建设）

教学内容

1.《组织学与胚胎学》本科课程

2.《组织学基本技术》研究生课程

教学研究

1.2020年主持广东省研究生教育创新示范课程建设项目《组织学基本技术》。

2.2018年主持教学质量与教学改革工程项目“广东省在线开放课程《组织学与胚胎学》”。

3.2015年主持校级教学成果培育项目“胚胎发育模型和胚胎标本实习暨陈列室建设”。

4.主编全国高等院校本科临床医学专业国家化教育“十三五”规划教材《组织学与胚胎学》1部，副主编教材3部，参编教材2部，发表教学论文3篇。

荣誉奖励

1.2019年感动南医——立德树人好导师”

2.2013年广东省“珠江学者”特聘教授

3.2010年 广东省高等学校“千百十工程”省级培养对象

4.2008年 教育部新世纪优秀人才支持计划

5.2009.09 南方医科大学“南医优秀教师”