李茫茫 教授

发布时间:2017-08-21 浏览次数:

48951


李茫茫 博士

教授,博士生导师


电子邮件: mangmangli@smu.edu.cn

电 话:020-61648397

通讯地址:广东省广州市白云区沙太南路1023号(510515)






人简介

李茫茫博士现为南方医科大学细胞生物学教授,回国前就职于美国国立卫生研究院国立癌症研究所,2001年四川大学获理学硕士学位,2008年中科院上海植物生理与生态研究所获理学博士学位,于2009至2014在年美国国立卫生研究院国立癌症研究所从事博士后研究工作,随后就职于该研究所继续从事研究工作。

李茫茫博士主要从事p53调控胚胎干细胞发生、发育及分化方面的研究,其研究成果发表于Cell Stem Cell (IF: 23.9)、Molecular Cell (IF: 16)、PNAS(IF: 11.1)、Theranostics(IF: 12.4)等高水平学术期刊上,并受邀在众多会议进行主题发言,同时担任Journal of Gene Therapy for Genetic Disorders编辑,Acta Biochimica et Biophysica Sinica、International Journal of Molecular Sciences、 Life Sciences 等杂志的特约审稿人。回国后当年获得国家自然科学基金面上项目一项、青年基金一项。2017年获国家重点研发计划干细胞及转化研究专项一项。


研究方向

p53调控胚胎干细胞发生、发育及分化


研究关键词

胚胎干细胞, 转录调控,间充质干细胞,脊髓损伤,转化医学

ESCs, transcriptional regulation, MSCs, spinal cord injury, translational medicine


表性论

1. Cao T#, Chen H#, Huang W#, Xu S, Liu P, Zou W, Pang M, Xu Y, Bai X, Liu B, Rong L, Cui ZK*, Li M*. hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits β3 and γ2 of the GABA A receptor. Theranostics. 2022 Mar 28;12(7):3057-3078. doi: 10.7150/thno.72015. PMID: 35547766; PMCID: PMC9065192. (IF= 12.4,JCR分区:Q1)

2. Li M, Gou H, Tripathi BK, Huang J, Jiang S, Dubois W, Waybright T, Lei M, Shi J, Zhou M, Huang J. An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells. Cell Stem Cell. 2015 Jun 4;16(6):669-83. doi: 10.1016/j.stem.2015.04.002. Epub 2015 Apr 30. PMID: 25936916; PMCID: PMC4458197. (IF= 23.9,JCR分区:Q1)

3. Li M, He Y, Dubois W, Wu X, Shi J, Huang J. Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. Molecular Cell. 2012 Apr 13;46(1):30-42. doi: 10.1016/j.molcel.2012.01.020. Epub 2012 Mar 1. PMID: 22387025; PMCID: PMC3327774. (IF= 16,JCR分区:Q1)

4. Lee KH#, Li M#, Michalowski AM, Zhang X, Liao H, Chen L, Xu Y, Wu X, Huang J. A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):69-74. doi: 10.1073/pnas.0909734107. Epub 2009 Dec 14. PMID: 20018659; PMCID: PMC2806696. (IF= 11.1,JCR分区:Q1)

5. Cao T#, Chen H#, Pang M#, Xu S, Wen H, Liu B*, Rong L*, Li M*. Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury. Neural Regen Res. 2022 Aug;17(8):1785-1794. doi: 10.4103/1673-5374.332151. PMID: 35017439; PMCID: PMC8820722. (IF= 6.1,JCR分区:Q2)

6. Wang L#, Tan X#, Chen L#, Xu S, Huang W, Chen N, Wu Y, Wang C, Zhou D, Li M. Sall4 Guides p53-Mediated Enhancer Interference upon DNA Damage in Mouse Embryonic Stem Cells. Stem Cells. 2022 Nov 29;40(11):1008-1019. doi: 10.1093/stmcls/sxac058. PMID: 35977539. (IF= 5.2,JCR分区:Q1)

7. Zeng P, Tang X, Wu T, Tian Q, Li M*, Ding J*. Identification of potential regulatory genes for embryonic stem cell self-renewal and pluripotency by random forest. Nan Fang Yi Ke Da Xue Xue Bao. 2021 Aug 20;41(8):1234-1238. Chinese. doi: 10.12122/j.issn.1673-4254.2021.08.16. PMID: 34549716; PMCID: PMC8527233.

8. Yang Y#, Cao TT#, Tian Z#, Gao H, Wen H, Pang M, He W, Wang N, Chen Y, Wang Y, Li H, Lin J, Kang Z, Li M*, Liu B*, Rong L*. Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study. Exp Cell Res. 2020 Oct 15;395(2):112184. doi: 10.1016/j.yexcr.2020.112184. Epub 2020 Jul 21. PMID: 32707134. (IF= 4.145,JCR分区:Q3)

9. Li M, He Y, Feng X, Huang J. Genome-wide studies of the transcriptional regulation by p53. Biochim Biophys Acta. 2012 Jul;1819(7):684-7. doi: 10.1016/j.bbagrm.2012.02.002. Epub 2012 Feb 10. PMID: 22348878; PMCID: PMC3366165. (IF= 4.7)

10. Li M, Huang J. A new puzzling role of p53 in mouse embryonic stem cells. Cell Cycle. 2010 May;9(9):1669-70. doi: 10.4161/cc.9.9.11596. Epub 2010 May 19. PMID: 20404507; PMCID: PMC3273866. (IF= 4.3,JCR分区:Q1)

11. Li M, Li P, Song R, Xu Z. An induced hypersensitive-like response limits expression of foreign peptides via a recombinant TMV-based vector in a susceptible tobacco. PLoS One. 2010 Nov 29;5(11):e15087. doi: 10.1371/journal.pone.0015087. PMID: 21124743; PMCID: PMC2993970. (IF= 3.7,JCR分区:Q1)

12. Li Q, Li M, Jiang L, Zhang Q, Song R, Xu Z. TMV recombinants encoding fused foreign transmembrane domains to the CP subunit caused local necrotic response on susceptible tobacco. Virology. 2006 May 10;348(2):253-9. doi: 10.1016/j.virol.2005.11.013. Epub 2006 Mar 20. PMID: 16542697; PMCID: PMC7111735. (IF= 3.7,JCR分区:Q2)

13. Jiang L, Li Q, Li M, Zhou Z, Wu L, Fan J, Zhang Q, Zhu H, Xu Z. A modified TMV-based vector facilitates the expression of longer foreign epitopes in tobacco. Vaccine. 2006 Jan 12;24(2):109-15. doi: 10.1016/j.vaccine.2005.09.060. PMID: 16337317. (IF= 5.5,JCR分区:Q1)

14. Li Q, Jiang L, Li M, Li P, Zhang Q, Song R, Xu Z. Morphology and stability changes of recombinant TMV particles caused by a cysteine residue in the foreign peptide fused to the coat protein. J Virol Methods. 2007 Mar;140(1-2):212-7. doi: 10.1016/j.jviromet.2006.10.011. Epub 2006 Nov 30. PMID: 17140672. (IF= 3.1,JCR分区:Q3)


代表性课题



教课程(课程及教材建设)

医学细胞生物学


荣誉奖励

1. 2009-2014年获得美国国立卫生研究院Visiting Fellowship奖学金资助 (为期5年) 。

2. 2014-2017年作为研究助理受聘于美国国立卫生研究院,获得Research Fellowship奖学金资助(为期3年)。

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